CLN2 disease is a rapidly progressing pediatric neurodegenerative disorder

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—Find CLN2 Early    

The Natural Course of CLN2 Disease is Rapid

Children with CLN2 disease commonly experience a complete loss of cognitive abilities, motor function, and vision within the first decade of life.1,2

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Earlier Diagnosis is Critical with Testing

Given the rapid rate of progression, early diagnosis is essential to ensure that families can benefit from CLN2 management strategies and maximize quality time.3,4

Recognize Early Signs to Shorten Time to Diagnosis

Optimize Care With CLN2 Disease Management Strategies

Experts have identified CLN2 disease management strategies that can greatly impact patient care and quality of life.4

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References:

  1. Schulz A, Kohlschütter A, Mink J, Simonati A, Williams R. NCL diseases – clinical perspectives. Biochimica et Biophysica Acta. 2013;1832:1801-1806.
  2. Malik K, Santucci K, Sremba L, et al. Neuronal Ceroid Lipofuscinoses Overview. 2001 Oct 10 [Updated 2025 May 29]. In: Adam MP, Bick S, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026.
  3. Nickel M, Simonati A, Jacoby D, et al. Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study. Lancet Child Adolesc Health. 2018 Aug;2(8):582-590. doi: 10.1016/S2352-4642(18)30179-2.
  4. Williams RE, Adams HR, Blohm M, et al. Management Strategies for CLN2 Disease. Pediatr Neurol. 2017 Apr;69:102-112. doi: 10.1016/j.pediatrneurol.2017.01.034.