Description
Data collected in the CLARITY study have been used to develop new growth curves. These will support clinical practice and research for people with achondroplasia. The findings in this well-phenotyped cohort may be studied with other global populations to gain further insight into environmental or ethnic influences on growth.
Achondroplasia growth charts have been produced, but typically from a mix of data types from as far back as 1967. A key objective of CLARITY was to use what is likely to be the largest dataset of anthropometric measures in achondroplasia to develop new growth curves and reference tables that could be used for clinical use and research in modern achondroplasia populations.
Importantly, weight-for-age values greater than three standard deviations above the mean were excluded from the weight-for-height and weight-for-age curves to create a stricter tool, a stricter tool for weight assessment in this population. The resulting novel weight-for-height curves are divided into three groups based on height to allow for optimal resolution for clinical use. This large cohort may also be contrasted to individuals and populations who undergo novel medical therapies and surgical interventions to ascertain the effect of those treatments.
References:
Hoover‑Fong JE, Schulze KJ, Alade AY, Bober MB, Gough E, Hashmi SS, Hecht JT, Legare JM, Little ME, Modaff P, Pauli RM, Rodriguez‑Buritica DF, Serna ME, Smid C, Liu C, McGready J Orphanet J Rare Dis 2021;16(1):522