{"id":851,"date":"2023-01-12T07:11:00","date_gmt":"2023-01-12T07:11:00","guid":{"rendered":"https:\/\/pkudsehcp-dev-001.azurewebsites.net\/pt-br\/?page_id=851"},"modified":"2024-09-03T10:48:11","modified_gmt":"2024-09-03T10:48:11","slug":"faqs","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/pt-br\/pku\/faqs\/","title":{"rendered":"FAQs"},"content":{"rendered":"<div id=\"acf-block-6408986be6d1f\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/PKU_Tree_DSE_Website_Interior_2022_v1_RGB_FIN.jpg?v=0.90);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/03\/hero-815x800.jpg);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>Perguntas frequentes sobre a fenilceton\u00faria\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-6408986be6d47\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-6408986be6d5d\" class=\"block-wysiwyg\">\n            <h2>Analise as perguntas comuns sobre a fenilceton\u00faria (PKU)<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6408986be6df8\" class=\"block accordion\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                                <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>O que causa a PKU?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>A fenilceton\u00faria (PKU) \u00e9 um erro inato do metabolismo da fenilalanina (Phe) causado por variantes no gene <em>PAH<\/em>, que codifica a enzima fenilalanina hidroxilase (PAH). Essas variantes levam \u00e0 defici\u00eancia total ou parcial da atividade enzim\u00e1tica da PAH, resultando na incapacidade de metabolizar o amino\u00e1cido Phe.<\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Como a PKU afeta o c\u00e9rebro?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>Como a enzima PAH catalisa a hidroxila\u00e7\u00e3o de Phe em tirosina (Tyr), a convers\u00e3o de Phe em Tyr \u00e9 prejudicada. Isso faz com que o amino\u00e1cido Phe se acumule no sangue e no c\u00e9rebro, levando a defici\u00eancia intelectual, bem como a consequ\u00eancias neurol\u00f3gicas, neuropsiqui\u00e1tricas e psicossociais.<sup>4<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/genetica-e-fisiopatologia\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>A PKU pode causar danos cerebrais?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>Se n\u00e3o forem adequadamente controlados, os n\u00edveis excessivos de Phe, que s\u00e3o t\u00f3xicos para o c\u00e9rebro, interrompem a neurofisiologia normal. N\u00edveis elevados de Phe podem levar a complica\u00e7\u00f5es neurol\u00f3gicas e neuropsicol\u00f3gicas graves, afetando a maneira como as pessoas com PKU pensam, sentem e agem.<sup>1,2,6,7<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>PKU: qu\u00e3o comum \u00e9?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>No Brasil, a preval\u00eancia estimada de PKU \u00e9 de 1 caso a cada 25.000 nascimentos.<\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/visao-geral\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Por quanto tempo voc\u00ea controla a PKU?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>O American College of Medical Genetics and Genomics divulgou diretrizes em 2014 sobre o diagn\u00f3stico e o tratamento da PKU: o tratamento deve ser iniciado o mais cedo poss\u00edvel e mantido por toda a vida; os n\u00edveis sangu\u00edneos de Phe devem ser mantidos em entre os n\u00edveis entre 120-360 \u03bcmol\/L para pacientes at\u00e9 12 anos, e entre 120-600 \u03bcmol\/L para pacientes com 12 ou mais anos durante toda a vida; durante toda a vida; e qualquer combina\u00e7\u00e3o de terapias que ajude a manter os n\u00edveis sangu\u00edneos de Phe na faixa recomendada \u00e9 apropriada<sup>3,7<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/metas-de-gerenciamento\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Quais s\u00e3o os sintomas comuns da PKU?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>Os efeitos da Phe elevada s\u00e3o sentidos durante toda a vida do paciente.<sup>3,7<\/sup><\/p>\n<p>Jovens adultos e adultos com Phe n\u00e3o controlada podem apresentar sintomas neurol\u00f3gicos, psiqui\u00e1tricos e cognitivos, incluindo:<\/p>\n<ul>\n<li>Depress\u00e3o<\/li>\n<li>Ansiedade<\/li>\n<li>Defici\u00eancias no funcionamento executivo<\/li>\n<li>IQ mais baixo do que o da popula\u00e7\u00e3o adulta em geral<\/li>\n<\/ul>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Quais comorbidades est\u00e3o associadas \u00e0 PKU?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>O \u00f4nus da PKU vai al\u00e9m do c\u00e9rebro e se estende a muitos aspectos da vida adulta. Os adultos com PKU t\u00eam um risco maior de v\u00e1rias comorbidades multissist\u00eamicas.<sup>8<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Qual \u00e9 a dificuldade de controlar os n\u00edveis de Phe no sangue?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>O controle da Phe geralmente abaixa durante a adolesc\u00eancia, aumentando a gravidade dos sintomas neuropsicol\u00f3gicos e afetando negativamente a qualidade de vida.<sup>2,3<\/sup><br \/>\nPacientes adultos jovens e adultos podem ficar presos em um ciclo de decl\u00ednio, dificultando a ades\u00e3o \u00e0 dieta e o controle da PKU.<sup>6,9<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/necessidade-nao-atendida\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Qual \u00e9 a dieta para PKU?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>A base do tratamento da PKU \u00e9 o controle diet\u00e9tico por toda a vida com uma dieta com restri\u00e7\u00e3o de Phe.<sup>3,10<\/sup><\/p>\n<p>Uma dieta com baixo teor de Phe consiste em tr\u00eas partes principais:<sup>3,10<\/sup><\/p>\n<ul>\n<li>Restri\u00e7\u00e3o da prote\u00edna natural<\/li>\n<li>Alimentos\/f\u00f3rmulas\/suplementos medicinais<\/li>\n<li>Alimentos modificados com baixo teor de prote\u00edna<\/li>\n<\/ul>\n<p>Embora a dieta com restri\u00e7\u00e3o de Phe continue sendo a pedra angular do tratamento de pacientes com PKU,  existem desafios que podem dificultar a ades\u00e3o estrita dos pacientes.<sup>3,11<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/dieta-para-pku\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Qual \u00e9 o benef\u00edcio de reduzir os n\u00edveis de Phe no sangue?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>A redu\u00e7\u00e3o da Phe \u00e9 reconhecida como a principal estrat\u00e9gia no controle da PKU.<sup>3<\/sup><\/p>\n<p>Os n\u00edveis elevados do amino\u00e1cido Phe est\u00e3o correlacionados com a gravidade dos sintomas neuropsicol\u00f3gicos, que geralmente melhoram com a redu\u00e7\u00e3o dos n\u00edveis de Phe.<sup>3<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/metas-de-gerenciamento\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Quais s\u00e3o as recomenda\u00e7\u00f5es atuais das diretrizes cl\u00ednicas para os n\u00edveis de Phe no sangue?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>De acordo com especialistas europeus, recomenda-se iniciar o tratamento o mais cedo poss\u00edvel e manter os n\u00edveis entre 120-360 \u03bcmol\/L para pacientes at\u00e9 12 anos, e entre 120-600 \u03bcmol\/L para pacientes com 12 ou mais anos<sup>7<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/metas-de-gerenciamento\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2>Como a PKU \u00e9 tratada?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\">\n                                                            <p>Globalmente, a abordagem para o controle da PKU tem sido uma dieta altamente restrita em Phe, terapia nutricional medicamentosa e alimentos com baixo teor de prote\u00edna. Em combina\u00e7\u00e3o com uma dieta com baixo teor de Phe, tamb\u00e9m est\u00e3o dispon\u00edveis medicamentos prescritos.<sup>3,10<\/sup><\/p>\n<p><a href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/opcoes-de-tratamento-da-pku\/\">Leia mais &gt;<\/a><\/p>\n                                                    <\/div>\n                    <\/div>\n                            \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6408986be6e42\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6408986be6e55\" class=\"block wrapped-content block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-6408986be6e65\" class=\"block-wysiwyg\">\n            <h2>Saiba mais sobre a PKU<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6408986be6e7a\" class=\"block cards cards-2-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-6408986be6e96\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/symptoms_icon.svg\" alt=\"\u00cdcone de sintomas de n\u00edveis descontrolados de Phe\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Conhe\u00e7a os sintomas da PKU n\u00e3o controlada\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/\" target=\"_self\">Saiba mais<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-6408986be6eb0\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/experts_say_icon.svg\" alt=\"\u00cdcone de especialistas\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Ou\u00e7a o que dizem os especialistas\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/conversando-com-seus-pacientes\/\" target=\"_self\">Saiba mais<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"conecte-se-conosco\" class=\"block hcp-sign-up-form\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                            <h2>Mantenha-se conectado com as informa\u00e7\u00f5es mais recentes sobre PKU\n<\/h2>\n                        <div class=\"block form-box\">\n                                    <p>Registre-se abaixo para entrar em contato com um representante da BioMarin, saber mais sobre os pr\u00f3ximos eventos e\/ou not\u00edcias sobre PKU ou solicitar uma discuss\u00e3o entre pares.<\/p>\n<p><strong>* Campos obrigat\u00f3rios<\/strong><\/p>\n                \n                <form id=\"hcp-sign-up\" name=\"Stay connected with the latest PKU information\">\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"connect-local-rep\" name=\"connect_local_rep\">\n                        <label for=\"connect-local-rep\">Conecte-se com um representante local da BioMarin<\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"first-name\">Primeiro nome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"first-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu primeiro nome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"last-name\">Sobrenome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"last-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu sobrenome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"medical-speciality\">Especialidade<span class=\"required\">*<\/span><\/label>\n                        <select class=\"text\" id=\"medical-speciality\" required\n                        data-pristine-required-message=\"Selecione sua especialidade m\u00e9dica.\">\n                            <option value=\"\">Por favor, selecione<\/option>\n                            <option value=\"Anesthesiology\">Anestesiologia<\/option>\n                            <option value=\"Audiology\">Audiologia<\/option>\n                            <option value=\"Behavioral Neurology &#038; Neuropsychiatry\">Neurologia e Neuropsiquiatria Comportamental<\/option>\n                            <option value=\"Biology\">Biologia<\/option>\n                            <option value=\"Biomedical Engineering\">Engenharia Biom\u00e9dica<\/option>\n                            <option value=\"Cardiology\">Cardiologia<\/option>\n                            <option value=\"Clinical Biochemical Genetics\">Bioqu\u00edmica em Gen\u00e9tica Cl\u00ednica<\/option>\n                            <option value=\"Dentistry and Odontology\">Odontologia<\/option>\n                            <option value=\"Dermatology\">Dermatologia<\/option>\n                            <option value=\"Diagnostic Radiology\">Radiologia Diagn\u00f3stica<\/option>\n                            <option value=\"Electoencephalography\">Eletroencefalografia<\/option>\n                            <option value=\"Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia, Diabetes e Metabolismo<\/option>\n                            <option value=\"ENT\/Otorhinolaryngologist\">Otorrinolaringologista<\/option>\n                            <option value=\"Epileptology\">Epileptologia<\/option>\n                            <option value=\"Gastroenterology\">Gastroenterologia<\/option>\n                            <option value=\"General Practice\/Family\">Cl\u00ednica Geral\/M\u00e9dico de Fam\u00edlia<\/option>\n                            <option value=\"Genetics\">Gen\u00e9tica<\/option>\n                            <option value=\"Hearing and Speech\">Fonoaudiologia<\/option>\n                            <option value=\"Hematology\">Hematologia<\/option>\n                            <option value=\"Hematology &#038; Oncology\">Hematologia e Oncologia<\/option>\n                            <option value=\"Hepatology\">Hepatologia<\/option>\n                            <option value=\"Infectious Diseases\">Infectologia<\/option>\n                            <option value=\"Intensive Care\">Tratamento Intensivo<\/option>\n                            <option value=\"Internal Medicine\">Medicina Interna<\/option>\n                            <option value=\"Kinesiology\">Cinesiologia<\/option>\n                            <option value=\"Laboratory Management\">An\u00e1lises Laboratoriais\/Exames Cl\u00ednicos<\/option>\n                            <option value=\"Medical Student\">Estudante de medicina<\/option>\n                            <option value=\"Neonatology\">Neonatologia<\/option>\n                            <option value=\"Nephrology\">Nefrologia<\/option>\n                            <option value=\"Neurology\">Neurologia<\/option>\n                            <option value=\"Neuromuscular Medicine\">Medicina Neuromuscular<\/option>\n                            <option value=\"Nutrition, Metabolic\">Nutri\u00e7\u00e3o metab\u00f3lica<\/option>\n                            <option value=\"Obstetrics\">Obstetr\u00edcia<\/option>\n                            <option value=\"Occupation Health\">Sa\u00fade Ocupacional<\/option>\n                            <option value=\"Oncology\">Oncologia<\/option>\n                            <option value=\"Ophthalmology\">Oftalmologia<\/option>\n                            <option value=\"Orthopedics\">Ortopedia<\/option>\n                            <option value=\"Paliative\/Hospice\">Paliativo<\/option>\n                            <option value=\"Pediatric Allergy\/Immunology\">Alergia\/Imunologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Anesthesiology\">Anestesiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Cardiology\">Cardiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Dentistry\">Dentista Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Endocrinology\">Endocrinologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia Pedi\u00e1trica, Diabetes e Metabolismo<\/option>\n                            <option value=\"Pediatric ENT\">Otorrinolaringologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology\">Gastroenterologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology &#038; Metabolism\">Gastroenterologia Pedi\u00e1trica e Metabolismo<\/option>\n                            <option value=\"Pediatric Genetics\">Gen\u00e9tica Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology\">Hematologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology-Oncology\">Hematologia-Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Metabolism\">Metabolismo Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Neurology\">Neurologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Neurosurgery\">Neurocirurgia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Oncology\">Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Ophthalmology and Strabismus Specialist\">Especialista em oftalmologia pedi\u00e1trica e estrabismo<\/option>\n                            <option value=\"Pediatric Orthopedics\">Ortopedia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Pneumology\">Pneumologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Radiology\">Radiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Rheumatology\">Reumatologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatrics\">Pediatria<\/option>\n                            <option value=\"Phonoaudiology\">Fonoaudiologia<\/option>\n                            <option value=\"Physiatry\">Fisiatria<\/option>\n                            <option value=\"Physician Assistant\">M\u00e9dico Assistente<\/option>\n                            <option value=\"Physiotherapy\">Fisioterapia<\/option>\n                            <option value=\"Primary Care\">Cuidados Prim\u00e1rios<\/option>\n                            <option value=\"Psychology\/Psychiatry\">Psicologia\/Psiquiatria<\/option>\n                            <option value=\"Pulmonology\">Pneumologia<\/option>\n                            <option value=\"Radiology (MRI imaging)\">Radiologia<\/option>\n                            <option value=\"Research\">Pesquisador<\/option>\n                            <option value=\"Rheumatology\">Reumatologia<\/option>\n                            <option value=\"Surgery\">Cirurgia<\/option>\n                            <option value=\"Traumatology\">Traumatologia<\/option>\n                            <option value=\"Unknown\">Outro<\/option>\n                        <\/select>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"email\">Endere\u00e7o de e-mail<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"email\" type=\"email\" required\n                        data-pristine-required-message=\"Digite seu endere\u00e7o de e-mail.\"\n                        data-pristine-email-message=\"Esse campo requer um endere\u00e7o de e-mail v\u00e1lido.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"state\">Estado<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"state\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu estado.\">\n                    <\/div>\n\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"accept-ts-cs\" name=\"accept_ts_cs\" required\n                        data-pristine-required-message=\"Por favor, aceite os termos de uso.\">\n                        <label for=\"accept-ts-cs\">Ao marcar a caixa \u00e0 esquerda e clicar em &#8220;Enviar&#8221; abaixo, eu confirmo que tenho pelo menos 18 anos de idade; e confirmo que concordo com a <a href=\"https:\/\/www.biomarin.com\/data-privacy-center\/\" target=\"_blank\">Pol\u00edtica de Privacidade<\/a> e <a href=\"https:\/\/medinfoterms.com\/\" target=\"_blank\">Termos de Uso da BioMarin<\/a>; consinto que a BioMarin, seus sucessores, agentes e\/ou cession\u00e1rios usem o endere\u00e7o de e-mail que forneci para me manter informado sobre atualiza\u00e7\u00f5es de not\u00edcias e desenvolvimentos sobre a PKU; e confirmo que entendo que essas comunica\u00e7\u00f5es\/materiais podem conter informa\u00e7\u00f5es que comercializam ou anunciam produtos, bens ou servi\u00e7os da BioMarin.<span class=\"required\">*<\/span><\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <input type=\"submit\" class=\"button\" value=\"Enviar\">\n                    <\/div>\n                <\/form>\n                <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n            <\/div>\n\n            <div class=\"block form-success-confirmation\" style=\"display:none;\">\n                                    <h3>Muito obrigado!<\/h3>\n<p>Entraremos em contato em breve com informa\u00e7\u00f5es adicionais.<\/p>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6408986be6f09\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Refer\u00eancias:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Ashe K, Kelso W, Farrand S, et al. Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. <em>Front Psychiatry.<\/em> 2019;10:561. doi:10.3389\/fpsyt.2019.00561.\n<\/span><\/li>\n                                                                                                                                                <li><span>Brown CS, Lichter-Konecki U. Phenylketonuria (PKU): a problem solved? <em>Mol Genet Metab Rep<\/em>. 2016;6:8-12.\n<\/span><\/li>\n                                                                                                                                                <li><span>Vockley J, Andersson HC, Antshel KM, et al; American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guidelines. <em>Genet Med<\/em>. 2014;16(2):188-200.\n<\/span><\/li>\n                                                                                                                                                <li><span>Blau N, van Spronsen FJ, Levy HL. Phenylketonuria. <em>Lancet<\/em>. 2010;376(9750):1417-1427.\n<\/span><\/li>\n                                                                                                                                                <li><span>Rocha JC, MacDonald A. Treatment options and dietary supplements for patients with phenylketonuria. <em>Expert Opin Orphan Drugs<\/em>. 2018;6(11):667-681.\n<\/span><\/li>\n                                                                                                                                                <li><span>Bilder DA, Noel JK, Baker ER, et al. Systematic review and meta-analysis of neuropsychiatric symptoms and executive functioning in adults with phenylketonuria.<em> Dev Neuropsychol<\/em>. 2016;41(4):245-260\n<\/span><\/li>\n                                                                                                                                                <li><span>van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines of phenylketonuria: diagnosis and treatment. <em>Orphanet J Rare Dis<\/em>. 2017;12(1):162. doi: 10.1186\/s13023-017-0685-22.\n<\/span><\/li>\n                                                                                                                                                <li><span>Burton BK, Jones KB, Cederbaum S, et al. Prevalence of comorbid conditions among adult patients diagnosed with phenylketonuria. <em>Mol Genet Metab<\/em>. 2018;125(3):228-234.\n<\/span><\/li>\n                                                                                                                                                <li><span>Thomas J, Nguyen-Driver M, Bausell H, Breck J, Zambrano J, Birardi V. Strategies for successful long-term engagement of adults with phenylalanine hydroxylase deficiency returning to the clinic. <em>J Inborn Errors Metab Screen<\/em>. 2017;5:1-9.\n<\/span><\/li>\n                                                                                                                                                <li><span>Rocha JC, MacDonald A. Dietary intervention in the management of phenylketonuria: current perspectives. <em>Pediatric Health Med Ther<\/em>. 2016;7:155-163.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ford S, O\u2019Driscoll M, MacDonald A. Living with phenylketonuria: lessons from the PKU community. <em>Mol Genet Metab Rep<\/em>. 2018;17:57-63.\n<\/span><\/li>\n                                                                                                                                                <li><span>Evinc SG, Pektas E, Foto-\u00d6zdemir D, et al. Cognitive and behavioral impairment in mild hyperphenylalaninemia. <em>Turk J Pediatr<\/em>. 2018;60(6):617-624.\n<\/span><\/li>\n                                                                                                                                                <li><span>Jahja R, Huijbregts S, de Sonneville LMJ, van der Meere JJ, van Spronsen FJ. Neurocognitive evidence for revision of treatment targets and guidelines for phenylketonuria. <em>J Pediatr<\/em>. 2014;164(4):895-899.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-851","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Perguntas frequentes sobre fenilceton\u00faria (PKU)<\/title>\n<meta name=\"description\" content=\"Veja as perguntas e respostas mais comuns sobre a fenilceton\u00faria (PKU), um dist\u00farbio gen\u00e9tico e cujo verdadeiro impacto sobre os pacientes e 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