{"id":670,"date":"2023-01-12T04:55:15","date_gmt":"2023-01-12T04:55:15","guid":{"rendered":"https:\/\/pkudsehcp-dev-001.azurewebsites.net\/pt-br\/?page_id=670"},"modified":"2024-09-03T10:42:57","modified_gmt":"2024-09-03T10:42:57","slug":"metas-de-gerenciamento","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/pt-br\/pku\/metas-de-gerenciamento\/","title":{"rendered":"Objetivos do Manejo"},"content":{"rendered":"<div id=\"acf-block-63f65a277c913\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/PKU_Tree_DSE_Website_Interior_2022_v1_RGB_FIN.jpg?v=0.90);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/03\/hero-815x800.jpg);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>A redu\u00e7\u00e3o da fenilalanina (Phe) \u00e9 fundamental para o tratamento<sup>1<\/sup>\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"Managing-PKU\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>Controle da fenilceton\u00faria (PKU)<\/h2>\n<p>Um conhecimento consider\u00e1vel foi adquirido com rela\u00e7\u00e3o \u00e0 melhora dos sintomas neurol\u00f3gicos e neuropsicossociais associados \u00e0 redu\u00e7\u00e3o da fenilalanina (Phe).<sup>2,3<\/sup><\/p>\n<ul>\n<li>A Phe elevada se correlaciona com a gravidade dos sintomas neuropsicol\u00f3gicos, que geralmente melhora com a redu\u00e7\u00e3o da Phe<sup>2<\/sup><\/li>\n<li>Evid\u00eancias cl\u00ednicas emergentes sugerem que benef\u00edcios adicionais podem ser obtidos quando a Phe est\u00e1 abaixo dos n\u00edveis recomendados<sup>4,5<\/sup><\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                                                                                                \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-responsive image-rounded\">\n                                                                                            <div class=\"image-desktop\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/02\/lower_phe_new.svg\" alt=\"\u00cdcone de controle metab\u00f3lico\" \/>                                                <\/div>\n                                                <div class=\"image-mobile\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/phe_icon_-e1679409146117.png?v=0.90\" alt=\"\u00cdcone de baixo Phe\" \/>                                                <\/div>\n                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"Guidlines\" class=\"block split-content equal-bias bg-band bg-band-alternative block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>As diretrizes recomendam a manuten\u00e7\u00e3o vital\u00edcia de concentra\u00e7\u00f5es de<br \/>\nPhe &lt; 600 &#181;mol\/L<sup>6<\/sup><\/h2>\n                                                                                                                                <ul>\n<li>O tratamento deve ser iniciado o mais cedo poss\u00edvel e mantido por toda a vida<\/li>\n<li>Qualquer combina\u00e7\u00e3o de tratamentos que ajude a manter os n\u00edveis de Phe no sangue dentro da faixa recomendada \u00e9 adequada<\/li>\n<\/ul>\n<p>Foi publicado no Orphanet Journal of Rare Diseases as diretrizes europeias sobre o diagn\u00f3stico e o tratamento da fenilceton\u00faria (PKU) &#8211; Veja o artigo completo <a href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-017-0685-2?optIn=false\" target=\"_blank\" rel=\"noopener\">aqui<\/a><\/p>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                                                                                                \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-responsive image-rounded\">\n                                                                                            <div class=\"image-desktop\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/phe_600_icon.svg\" alt=\"\u00cdcone de manuten\u00e7\u00e3o das concentra\u00e7\u00f5es de Phe\" \/>                                                <\/div>\n                                                <div class=\"image-mobile\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/phe_600_icon_mobile2.svg\" alt=\"\u00cdcone de manuten\u00e7\u00e3o das concentra\u00e7\u00f5es de Phe\" \/>                                                <\/div>\n                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"50%\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/50percent_gfx_PT_NEW.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h2>\u00c9 importante reengajar jovens adultos e adultos com PKU que perderam o seguimento\/acompanhamento (LTFU)*<\/h2>\n<ul>\n<li>Os adultos que perderam o seguimento\/acompanhamento (LTFU) t\u00eam um controle e resultados ruins da PKU em compara\u00e7\u00e3o com os pacientes que apresentam um seguimento cl\u00ednico regularmente<sup>2<\/sup><\/li>\n<li>As diretrizes do ACMG (American College of Medical Genetics) afirmam que os pacientes que interromperam a terapia (diet\u00e9tica ou medicamentosa) provavelmente observar\u00e3o melhorias em seus sintomas se retornarem ao tratamento<sup>2<\/sup><\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277e990\" class=\"block wrapped-content block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"What-experts-say\" class=\"block wrapped-content block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f65a277e9ac\" class=\"block-wysiwyg\">\n            <h2>O que os especialistas dizem sobre o reengajamento de pacientes que perderam o seguimento\/acompanhamento (LTFU)<sup>8<\/sup><\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277e9bc\" class=\"block cards cards-3-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f65a277e9cc\" class=\"card\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                \n                                                                                                            <h5>Assegure-se de que os pacientes estejam cientes das diretrizes atuais de tratamento da PKU<sup>8<\/sup><\/h5>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277e9db\" class=\"card\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                \n                                                                                                            <h5>Comunicar quaisquer novas op\u00e7\u00f5es de tratamento e dieta para PKU<sup>8<\/sup><\/h5>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277e9ec\" class=\"card\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                \n                                                                                                            <h5>Reconhecer e abordar os aspectos neuropsicol\u00f3gicos e neurocognitivos da PKU<sup>8<\/sup><\/h5>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277e9fe\" class=\"block cards cards-3-col block-tight-top\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f65a277ea0b\" class=\"card\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                \n                                                                                                            <h5>Priorizar pacientes adultos LTFU motivados<sup>8<\/sup><\/h5>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277ea19\" class=\"card\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                \n                                                                                                            <h5>Avaliar novas abordagens de contato com pacientes adultos LTFU<sup>8<\/sup><\/h5>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277ea26\" class=\"card\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                \n                                                                                                            <h5>Formalizar abordagens para rastrear e\/ou identificar pacientes adultos LTFU<sup>8<\/sup><\/h5>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"Expert-opinions\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f65a277ea3f\" class=\"block-wysiwyg\">\n            <h2>Opini\u00f5es de especialistas para gerenciar o retorno de pacientes LTFU com PKU<sup>9<\/sup><\/h2>\n    <\/div>\n\n<figure id=\"acf-block-63f65a277ea51\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/chemical_structure_PT_NEW.svg\" alt=\"M\u00e3o segura, parceiro, \u00edcones de suporte individuais e adicionais\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/chemical_structure_mobile_PT_NEW.svg\" alt=\"M\u00e3o segura, parceiro, \u00edcones de suporte individuais e adicionais\" \/>\t\t\t<\/div>\n            <\/div>\n            <figcaption><p><small>*Baseado em 2 publica\u00e7\u00f5es que resumem os resultados de um grupo de 8 adultos com PKU e que perderam o seguimento\/acompanhamento (LTFU), observados por 10 m\u00e9dicos, seguido de uma sess\u00e3o de aconselhamento com o grupo de m\u00e9dicos, e uma pesquisa on-line com 55 cl\u00ednicas de PKU dos EUA e uma reuni\u00e3o de especialistas com 15 membros de cl\u00ednicas de PKU dos EUA. Financiado pela BioMarin.<sup>8,9<\/sup><\/small><\/p>\n<\/figcaption>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277ea62\" class=\"block wrapped-content block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f65a277ea6f\" class=\"block-wysiwyg\">\n            <h2>Saiba mais sobre a PKU<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277ea7f\" class=\"block cards cards-2-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f65a277ea91\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/management_icon_v2.svg\" alt=\"\u00cdcone de op\u00e7\u00f5es de gerenciamento de PKU\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Conhecendo suas op\u00e7\u00f5es de tratamento da PKU\n<\/h4>\n        \n                                                                                                            <p>Em combina\u00e7\u00e3o com uma dieta restrita em fenilalanina (Phe), existem op\u00e7\u00f5es farmacol\u00f3gicas que podem ajudar a reduzir os n\u00edveis sangu\u00edneos de Phe em pacientes com PKU.<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/opcoes-de-tratamento-da-pku\/\" target=\"_self\">Saiba mais<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277eaa7\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/Phe_icon.svg\" alt=\"\u00cdcone de controle metab\u00f3lico\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Porque o controle metab\u00f3lico \u00e9 t\u00e3o importante<sup>9,10<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/\" target=\"_self\">Saiba mais<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"conecte-se-conosco\" class=\"block hcp-sign-up-form\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                            <h2>Mantenha-se conectado com as informa\u00e7\u00f5es mais recentes sobre PKU\n<\/h2>\n                        <div class=\"block form-box\">\n                                    <p>Registre-se abaixo para entrar em contato com um representante da BioMarin, saber mais sobre os pr\u00f3ximos eventos e\/ou not\u00edcias sobre PKU ou solicitar uma discuss\u00e3o entre pares.<\/p>\n<p><strong>* Campos obrigat\u00f3rios<\/strong><\/p>\n                \n                <form id=\"hcp-sign-up\" name=\"Stay connected with the latest PKU information\">\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"connect-local-rep\" name=\"connect_local_rep\">\n                        <label for=\"connect-local-rep\">Conecte-se com um representante local da BioMarin<\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"first-name\">Primeiro nome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"first-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu primeiro nome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"last-name\">Sobrenome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"last-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu sobrenome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"medical-speciality\">Especialidade<span class=\"required\">*<\/span><\/label>\n                        <select class=\"text\" id=\"medical-speciality\" required\n                        data-pristine-required-message=\"Selecione sua especialidade m\u00e9dica.\">\n                            <option value=\"\">Por favor, selecione<\/option>\n                            <option value=\"Anesthesiology\">Anestesiologia<\/option>\n                            <option value=\"Audiology\">Audiologia<\/option>\n                            <option value=\"Behavioral Neurology &#038; Neuropsychiatry\">Neurologia e Neuropsiquiatria Comportamental<\/option>\n                            <option value=\"Biology\">Biologia<\/option>\n                            <option value=\"Biomedical Engineering\">Engenharia Biom\u00e9dica<\/option>\n                            <option value=\"Cardiology\">Cardiologia<\/option>\n                            <option value=\"Clinical Biochemical Genetics\">Bioqu\u00edmica em Gen\u00e9tica Cl\u00ednica<\/option>\n                            <option value=\"Dentistry and Odontology\">Odontologia<\/option>\n                            <option value=\"Dermatology\">Dermatologia<\/option>\n                            <option value=\"Diagnostic Radiology\">Radiologia Diagn\u00f3stica<\/option>\n                            <option value=\"Electoencephalography\">Eletroencefalografia<\/option>\n                            <option value=\"Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia, Diabetes e Metabolismo<\/option>\n                            <option value=\"ENT\/Otorhinolaryngologist\">Otorrinolaringologista<\/option>\n                            <option value=\"Epileptology\">Epileptologia<\/option>\n                            <option value=\"Gastroenterology\">Gastroenterologia<\/option>\n                            <option value=\"General Practice\/Family\">Cl\u00ednica Geral\/M\u00e9dico de Fam\u00edlia<\/option>\n                            <option value=\"Genetics\">Gen\u00e9tica<\/option>\n                            <option value=\"Hearing and Speech\">Fonoaudiologia<\/option>\n                            <option value=\"Hematology\">Hematologia<\/option>\n                            <option value=\"Hematology &#038; Oncology\">Hematologia e Oncologia<\/option>\n                            <option value=\"Hepatology\">Hepatologia<\/option>\n                            <option value=\"Infectious Diseases\">Infectologia<\/option>\n                            <option value=\"Intensive Care\">Tratamento Intensivo<\/option>\n                            <option value=\"Internal Medicine\">Medicina Interna<\/option>\n                            <option value=\"Kinesiology\">Cinesiologia<\/option>\n                            <option value=\"Laboratory Management\">An\u00e1lises Laboratoriais\/Exames Cl\u00ednicos<\/option>\n                            <option value=\"Medical Student\">Estudante de medicina<\/option>\n                            <option value=\"Neonatology\">Neonatologia<\/option>\n                            <option value=\"Nephrology\">Nefrologia<\/option>\n                            <option value=\"Neurology\">Neurologia<\/option>\n                            <option value=\"Neuromuscular Medicine\">Medicina Neuromuscular<\/option>\n                            <option value=\"Nutrition, Metabolic\">Nutri\u00e7\u00e3o metab\u00f3lica<\/option>\n                            <option value=\"Obstetrics\">Obstetr\u00edcia<\/option>\n                            <option value=\"Occupation Health\">Sa\u00fade Ocupacional<\/option>\n                            <option value=\"Oncology\">Oncologia<\/option>\n                            <option value=\"Ophthalmology\">Oftalmologia<\/option>\n                            <option value=\"Orthopedics\">Ortopedia<\/option>\n                            <option value=\"Paliative\/Hospice\">Paliativo<\/option>\n                            <option value=\"Pediatric Allergy\/Immunology\">Alergia\/Imunologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Anesthesiology\">Anestesiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Cardiology\">Cardiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Dentistry\">Dentista Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Endocrinology\">Endocrinologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia Pedi\u00e1trica, Diabetes e Metabolismo<\/option>\n                            <option value=\"Pediatric ENT\">Otorrinolaringologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology\">Gastroenterologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology &#038; Metabolism\">Gastroenterologia Pedi\u00e1trica e Metabolismo<\/option>\n                            <option value=\"Pediatric Genetics\">Gen\u00e9tica Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology\">Hematologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology-Oncology\">Hematologia-Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Metabolism\">Metabolismo Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Neurology\">Neurologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Neurosurgery\">Neurocirurgia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Oncology\">Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Ophthalmology and Strabismus Specialist\">Especialista em oftalmologia pedi\u00e1trica e estrabismo<\/option>\n                            <option value=\"Pediatric Orthopedics\">Ortopedia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Pneumology\">Pneumologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Radiology\">Radiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Rheumatology\">Reumatologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatrics\">Pediatria<\/option>\n                            <option value=\"Phonoaudiology\">Fonoaudiologia<\/option>\n                            <option value=\"Physiatry\">Fisiatria<\/option>\n                            <option value=\"Physician Assistant\">M\u00e9dico Assistente<\/option>\n                            <option value=\"Physiotherapy\">Fisioterapia<\/option>\n                            <option value=\"Primary Care\">Cuidados Prim\u00e1rios<\/option>\n                            <option value=\"Psychology\/Psychiatry\">Psicologia\/Psiquiatria<\/option>\n                            <option value=\"Pulmonology\">Pneumologia<\/option>\n                            <option value=\"Radiology (MRI imaging)\">Radiologia<\/option>\n                            <option value=\"Research\">Pesquisador<\/option>\n                            <option value=\"Rheumatology\">Reumatologia<\/option>\n                            <option value=\"Surgery\">Cirurgia<\/option>\n                            <option value=\"Traumatology\">Traumatologia<\/option>\n                            <option value=\"Unknown\">Outro<\/option>\n                        <\/select>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"email\">Endere\u00e7o de e-mail<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"email\" type=\"email\" required\n                        data-pristine-required-message=\"Digite seu endere\u00e7o de e-mail.\"\n                        data-pristine-email-message=\"Esse campo requer um endere\u00e7o de e-mail v\u00e1lido.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"state\">Estado<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"state\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu estado.\">\n                    <\/div>\n\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"accept-ts-cs\" name=\"accept_ts_cs\" required\n                        data-pristine-required-message=\"Por favor, aceite os termos de uso.\">\n                        <label for=\"accept-ts-cs\">Ao marcar a caixa \u00e0 esquerda e clicar em &#8220;Enviar&#8221; abaixo, eu confirmo que tenho pelo menos 18 anos de idade; e confirmo que concordo com a <a href=\"https:\/\/www.biomarin.com\/data-privacy-center\/\" target=\"_blank\">Pol\u00edtica de Privacidade<\/a> e <a href=\"https:\/\/medinfoterms.com\/\" target=\"_blank\">Termos de Uso da BioMarin<\/a>; consinto que a BioMarin, seus sucessores, agentes e\/ou cession\u00e1rios usem o endere\u00e7o de e-mail que forneci para me manter informado sobre atualiza\u00e7\u00f5es de not\u00edcias e desenvolvimentos sobre a PKU; e confirmo que entendo que essas comunica\u00e7\u00f5es\/materiais podem conter informa\u00e7\u00f5es que comercializam ou anunciam produtos, bens ou servi\u00e7os da BioMarin.<span class=\"required\">*<\/span><\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <input type=\"submit\" class=\"button\" value=\"Enviar\">\n                    <\/div>\n                <\/form>\n                <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n            <\/div>\n\n            <div class=\"block form-success-confirmation\" style=\"display:none;\">\n                                    <h3>Muito obrigado!<\/h3>\n<p>Entraremos em contato em breve com informa\u00e7\u00f5es adicionais.<\/p>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f65a277eade\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Refer\u00eancias:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Ceberio L, Hermida \u00c1, Venegas E, et al. Phenylketonuria in the adult patient. <em>Expert Opin Orphan Drugs<\/em>. 2019;7(6):265-276.\n<\/span><\/li>\n                                                                                                                                                <li><span>Vockley J, Andersson HC, Antshel KM, et al. American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guidelines. <em>Genet Med<\/em>. 2014;16(2):188-200.\n<\/span><\/li>\n                                                                                                                                                <li><span>Bilder DA, Noel JK, Baker ER, et al. Systematic review and meta-analysis of neuropsychiatric symptoms and executive functioning in adults with phenylketonuria. <em>Dev Neuropsychol<\/em>. 2016;41(4):245-260.\n<\/span><\/li>\n                                                                                                                                                <li><span>Evinc SG, Pektas E, Foto-\u00d6zdemir D, et al. Cognitive and behavioral impairment in mild hyperphenylalaninemia. <em>Turk J Pediatr<\/em>. 2018;60(6):617-624.\n<\/span><\/li>\n                                                                                                                                                <li><span>Jahja R, Huijbregts S, de Sonneville LMJ, van der Meere JJ, van Spronsen FJ. Neurocognitive evidence for revision of treatment targets and guidelines for phenylketonuria. <em>J Pediatr<\/em>. 2014;164(4):895-899.\n<\/span><\/li>\n                                                                                                                                                <li><span>van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines of phenylketonuria: diagnosis and treatment. <em>Orphanet J Rare Dis.<\/em> 2017;12(1):162. doi: 10.1186\/s13023-017-0685-22.\n<\/span><\/li>\n                                                                                                                                                <li><span>Berry SA, Brown C, Grant M, et al. Newborn screening 50 years later: access issues faced by adults with PKU. <em>Genet Med<\/em>. 2013;15(8):591-599.\n<\/span><\/li>\n                                                                                                                                                <li><span>Beazer J, Breck J, Eggerding C, et al. the PKU Lost to Follow-up Recommendations Group. Strategies to engage lost to follow-up patients with phenylketonuria in the United States: best practice recommendations. <em>Mol Genet Metab Rep.<\/em> 2020;23:100571. doi: 10.1016\/j.ymgmr.2020.100571.\n<\/span><\/li>\n                                                                                                                                                <li><span>Thomas J, Nguyen-Driver M, Bausell H, Breck J, Zambrano J, Birardi V. Strategies for successful long-term engagement of adults with phenylalanine hydroxylase deficiency returning to the clinic. <em>J Inborn Errors Metab Screen<\/em>. 2017;5:1-9.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ashe K, Kelso W, Farrand S, et al. Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. <em>Front Psychiatry<\/em>. 2019;10:561. doi:10.3389\/fpsyt.2019.00561.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-670","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gerenciamento l Reduzir os n\u00edveis de fenilalanina (Phe) \u00e9 essencial<\/title>\n<meta name=\"description\" content=\"A redu\u00e7\u00e3o dos n\u00edveis de fenilalanina (Phe) \u00e9 a principal estrat\u00e9gia no tratamento da fenilceton\u00faria (PKU). 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