{"id":272,"date":"2023-01-11T12:19:31","date_gmt":"2023-01-11T12:19:31","guid":{"rendered":"https:\/\/pkudsehcp-dev-001.azurewebsites.net\/pt-br\/?page_id=272"},"modified":"2024-09-03T10:38:39","modified_gmt":"2024-09-03T10:38:39","slug":"desafios-do-pku","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/","title":{"rendered":"Desafios da Fenilceton\u00faria (PKU)"},"content":{"rendered":"<div id=\"acf-block-63f7515b0910c\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/12\/PT-hero-PKU-2000x745-1.jpg?v=0.90);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/03\/hero-815x800.jpg);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>O impacto da fenilceton\u00faria ao longo da vida \u00e9 pouco reconhecido<sup>1-3<\/sup>\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-63f7515b0914a\" class=\"block wrapped-content bg-band bg-band-alternative block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b09161\" class=\"block-wysiwyg\">\n            <h2>N\u00edveis elevados de fenilalanina (Phe) podem levar a sintomas graves de fenilceton\u00faria (PKU)<sup>4-6<\/sup><\/h2>\n    <\/div>\n\n<figure id=\"acf-block-63f7515b0917f\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/10\/prevalence_ratios_graph_PT-1.svg\" alt=\"Raz\u00f5es de preval\u00eancia estimadas de diagn\u00f3sticos para pacientes com fenilceton\u00faria em compara\u00e7\u00e3o com a imagem da tabela da popula\u00e7\u00e3o geral\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/01\/prevalence_ratios_mobile_PT90.svg\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n            <figcaption><p><small>Adaptado de Bilder <em>et al<\/em>. Mol Genet Metab. 2017.<\/small><\/p>\n<\/figcaption>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09199\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom block-remove-bottom-padding\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b091b3\" class=\"block-wysiwyg\">\n            <h2>Os efeitos da Phe elevada s\u00e3o sentidos durante toda a vida do paciente<sup>1<\/sup><\/h2>\n<ul>\n<li>O controle dos n\u00edveis de fenilalanina (Phe) em rec\u00e9m-nascidos e crian\u00e7as previne a defici\u00eancia intelectual permanente<sup>1,6<\/sup><\/li>\n<li>No entanto, adolescentes e adultos com Phe n\u00e3o controlada podem apresentar sintomas neurol\u00f3gicos, psiqui\u00e1tricos e cognitivos, incluindo:<sup>6<\/sup><\/li>\n<\/ul>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-66263816ceb23\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom block-remove-top-padding block-remove-bottom-padding\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<figure id=\"acf-block-66263816cedba\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/heads_desktop.svg\" alt=\"Funcionamento executivo e \u00edcones de QI\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/heads_mobile.svg\" alt=\"Funcionamento executivo e \u00edcones de QI\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09729\" class=\"block fact-box block-zero-bottom\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t    <h3>Estresse mental e emocional da fenilceton\u00faria<sup>7<\/sup>\n<\/h3>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Mesmo os pacientes com Phe no sangue \u2264500 \u00b5mol\/L na inf\u00e2ncia apresentaram uma frequ\u00eancia maior de diagn\u00f3sticos psiqui\u00e1tricos, como<\/p>\n\t\t\t\t\t\t\t\t                    <ul class=\"facts\">\n                                                                                                            <li>Transtorno de ansiedade generalizado\n<\/li>\n                                                                                                            <li>Transtorno depressivo\n<\/li>\n                                                                                                            <li>Transtorno da personalidade\n<\/li>\n                                                                                                            <li>Problemas de comportamento\n<\/li>\n                                                                                                            <li>Fobia espec\u00edfica\n<\/li>\n                                                                                                            <li>Mutismo seletivo\n<\/li>\n                                            <\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09764\" class=\"block cards cards-2-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"if-new\" class=\"block wrapped-content block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b0978d\" class=\"block wrapped-content block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b097a1\" class=\"block-wysiwyg\">\n            <h2>Os pacientes e seus cuidadores lutam contra os sintomas da PKU<sup>8<\/sup><\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b097bd\" class=\"block quote\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"quote-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"content-block\">\n\t\t\t\t\t\t<blockquote>\n\t\t\t\t\t\t    \t\t\t\t\t\t\t    <p>&#8220;Tenho momentos de vazio, em que n\u00e3o consigo pensar ou dizer as palavras que estou tentando dizer. Sinto ansiedade e fico paranoico&#8221;.<sup>8<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <cite>Paciente com PKU <\/cite>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b097d7\" class=\"block quote\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"quote-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"content-block\">\n\t\t\t\t\t\t<blockquote>\n\t\t\t\t\t\t    \t\t\t\t\t\t\t    <p>&#8220;Fico com &#8220;n\u00e9voa cerebral&#8221;, tendo a tend\u00eancia de ficar irritado e inquieto em ambientes sociais.&#8221;<sup>8<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <cite>Paciente com PKU <\/cite>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b097ef\" class=\"block quote\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"quote-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"content-block\">\n\t\t\t\t\t\t<blockquote>\n\t\t\t\t\t\t    \t\t\t\t\t\t\t    <p>&#8220;Quando voc\u00ea pode causar danos cerebrais irrevers\u00edveis ao seu filho, isso causa muita preocupa\u00e7\u00e3o, estresse e at\u00e9 mesmo p\u00e2nico.&#8221;<sup>8<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <cite>Pais <\/cite>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09802\" class=\"block wrapped-content bg-band bg-band-alternative block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b09817\" class=\"block-wysiwyg\">\n            <h2>O \u00f4nus da PKU vai al\u00e9m do c\u00e9rebro e se estende a muitos aspectos da vida adulta<sup>9<\/sup><\/h2>\n<p>Adultos com fenilceton\u00faria (PKU) t\u00eam um risco aumentado de v\u00e1rias comorbidades multissist\u00eamicas<sup>9<\/sup><\/p>\n    <\/div>\n\n<figure id=\"acf-block-63f7515b09850\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/10\/adjusted_prevalance_table_PT-1.svg\" alt=\"Raz\u00e3o de preval\u00eancia ajustada de condi\u00e7\u00f5es com\u00f3rbidas com pacientes com PKU em compara\u00e7\u00e3o com controles sem PKU imagem gr\u00e1fica\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/01\/adjusted_prevalance_table_mobile_PT46.svg\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n            <figcaption><p><small>Adaptado de Burton et al. <em>Mol Genet Metab<\/em>. 2018.<\/small><\/p>\n<\/figcaption>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09729\" class=\"block fact-box\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\t\t\t\t    <p style=\"text-align: center\"><strong>Pacientes com PKU lutam para manter n\u00edveis seguros de Phe no sangue<sup>10,11<\/sup><\/strong><\/p>\n\t\t\t\t\t\t\t\t                    <ul class=\"facts\">\n                                                                                                            <li>Uma dieta com restri\u00e7\u00e3o de Phe \u00e9 complexa e proporciona uma ingest\u00e3o inadequada de prote\u00ednas\n<\/li>\n                                                                                                            <li>O controle de Phe normalmente cai durante a adolesc\u00eancia\n<\/li>\n                                                                                                            <li>Na idade adulta, a maioria dos pacientes nos Estados Unidos e na Europa tem n\u00edveis de Phe que excedem as recomenda\u00e7\u00f5es das diretrizes\n<\/li>\n                                            <\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09897\" class=\"block wrapped-content block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b098a6\" class=\"block-wysiwyg\">\n            <h2>Saiba mais sobre PKU<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"learn-more-about-PKU\" class=\"block cards cards-3-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f7515b098d9\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/dietry_control.svg\" alt=\"Controle diet\u00e9tico com \u00edcone PKU\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Saiba mais sobre o controle da dieta com PKU<sup>1<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/dieta-para-pku\/\" target=\"_self\">Ir para Dieta para PKU<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b098f7\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/guidelines.svg\" alt=\"Acima do \u00edcone do intervalo Phe alvo\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>67% dos adultos com PKU est\u00e3o acima das faixas-alvo de Phe recomendadas<sup>11<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/necessidade-nao-atendida\/\" target=\"_self\">Saiba por qu\u00ea<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b0990f\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/management.svg\" alt=\"\u00cdcone de op\u00e7\u00f5es de gerenciamento de PKU\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Conhe\u00e7a suas op\u00e7\u00f5es de controle da PKU\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/opcoes-de-tratamento-da-pku\/\" target=\"_self\">Explorar<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09919\" class=\"block wrapped-content block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"conecte-se-conosco\" class=\"block hcp-sign-up-form\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                            <h2>Mantenha-se conectado com as informa\u00e7\u00f5es mais recentes sobre PKU\n<\/h2>\n                        <div class=\"block form-box\">\n                                    <p>Registre-se abaixo para entrar em contato com um representante da BioMarin, saber mais sobre os pr\u00f3ximos eventos e\/ou not\u00edcias sobre PKU ou solicitar uma discuss\u00e3o entre pares.<\/p>\n<p><strong>* Campos obrigat\u00f3rios<\/strong><\/p>\n                \n                <form id=\"hcp-sign-up\" name=\"Stay connected with the latest PKU information\">\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"connect-local-rep\" name=\"connect_local_rep\">\n                        <label for=\"connect-local-rep\">Conecte-se com um representante local da BioMarin<\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"first-name\">Primeiro nome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"first-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu primeiro nome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"last-name\">Sobrenome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"last-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu sobrenome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"medical-speciality\">Especialidade<span class=\"required\">*<\/span><\/label>\n                        <select class=\"text\" id=\"medical-speciality\" required\n                        data-pristine-required-message=\"Selecione sua especialidade m\u00e9dica.\">\n                            <option value=\"\">Por favor, selecione<\/option>\n                            <option value=\"Anesthesiology\">Anestesiologia<\/option>\n                            <option value=\"Audiology\">Audiologia<\/option>\n                            <option value=\"Behavioral Neurology &#038; Neuropsychiatry\">Neurologia e Neuropsiquiatria Comportamental<\/option>\n                            <option value=\"Biology\">Biologia<\/option>\n                            <option value=\"Biomedical Engineering\">Engenharia Biom\u00e9dica<\/option>\n                            <option value=\"Cardiology\">Cardiologia<\/option>\n                            <option value=\"Clinical Biochemical Genetics\">Bioqu\u00edmica em Gen\u00e9tica Cl\u00ednica<\/option>\n                            <option value=\"Dentistry and Odontology\">Odontologia<\/option>\n                            <option value=\"Dermatology\">Dermatologia<\/option>\n                            <option value=\"Diagnostic Radiology\">Radiologia Diagn\u00f3stica<\/option>\n                            <option value=\"Electoencephalography\">Eletroencefalografia<\/option>\n                            <option value=\"Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia, Diabetes e Metabolismo<\/option>\n                            <option value=\"ENT\/Otorhinolaryngologist\">Otorrinolaringologista<\/option>\n                            <option value=\"Epileptology\">Epileptologia<\/option>\n                            <option value=\"Gastroenterology\">Gastroenterologia<\/option>\n                            <option value=\"General Practice\/Family\">Cl\u00ednica Geral\/M\u00e9dico de Fam\u00edlia<\/option>\n                            <option value=\"Genetics\">Gen\u00e9tica<\/option>\n                            <option value=\"Hearing and Speech\">Fonoaudiologia<\/option>\n                            <option value=\"Hematology\">Hematologia<\/option>\n                            <option value=\"Hematology &#038; Oncology\">Hematologia e Oncologia<\/option>\n                            <option value=\"Hepatology\">Hepatologia<\/option>\n                            <option value=\"Infectious Diseases\">Infectologia<\/option>\n                            <option value=\"Intensive Care\">Tratamento Intensivo<\/option>\n                            <option value=\"Internal Medicine\">Medicina Interna<\/option>\n                            <option value=\"Kinesiology\">Cinesiologia<\/option>\n                            <option value=\"Laboratory Management\">An\u00e1lises Laboratoriais\/Exames Cl\u00ednicos<\/option>\n                            <option value=\"Medical Student\">Estudante de medicina<\/option>\n                            <option value=\"Neonatology\">Neonatologia<\/option>\n                            <option value=\"Nephrology\">Nefrologia<\/option>\n                            <option value=\"Neurology\">Neurologia<\/option>\n                            <option value=\"Neuromuscular Medicine\">Medicina Neuromuscular<\/option>\n                            <option value=\"Nutrition, Metabolic\">Nutri\u00e7\u00e3o metab\u00f3lica<\/option>\n                            <option value=\"Obstetrics\">Obstetr\u00edcia<\/option>\n                            <option value=\"Occupation Health\">Sa\u00fade Ocupacional<\/option>\n                            <option value=\"Oncology\">Oncologia<\/option>\n                            <option value=\"Ophthalmology\">Oftalmologia<\/option>\n                            <option value=\"Orthopedics\">Ortopedia<\/option>\n                            <option value=\"Paliative\/Hospice\">Paliativo<\/option>\n                            <option value=\"Pediatric Allergy\/Immunology\">Alergia\/Imunologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Anesthesiology\">Anestesiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Cardiology\">Cardiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Dentistry\">Dentista Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Endocrinology\">Endocrinologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia Pedi\u00e1trica, Diabetes e Metabolismo<\/option>\n                            <option value=\"Pediatric ENT\">Otorrinolaringologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology\">Gastroenterologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology &#038; Metabolism\">Gastroenterologia Pedi\u00e1trica e Metabolismo<\/option>\n                            <option value=\"Pediatric Genetics\">Gen\u00e9tica Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology\">Hematologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology-Oncology\">Hematologia-Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Metabolism\">Metabolismo Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Neurology\">Neurologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Neurosurgery\">Neurocirurgia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Oncology\">Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Ophthalmology and Strabismus Specialist\">Especialista em oftalmologia pedi\u00e1trica e estrabismo<\/option>\n                            <option value=\"Pediatric Orthopedics\">Ortopedia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Pneumology\">Pneumologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Radiology\">Radiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Rheumatology\">Reumatologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatrics\">Pediatria<\/option>\n                            <option value=\"Phonoaudiology\">Fonoaudiologia<\/option>\n                            <option value=\"Physiatry\">Fisiatria<\/option>\n                            <option value=\"Physician Assistant\">M\u00e9dico Assistente<\/option>\n                            <option value=\"Physiotherapy\">Fisioterapia<\/option>\n                            <option value=\"Primary Care\">Cuidados Prim\u00e1rios<\/option>\n                            <option value=\"Psychology\/Psychiatry\">Psicologia\/Psiquiatria<\/option>\n                            <option value=\"Pulmonology\">Pneumologia<\/option>\n                            <option value=\"Radiology (MRI imaging)\">Radiologia<\/option>\n                            <option value=\"Research\">Pesquisador<\/option>\n                            <option value=\"Rheumatology\">Reumatologia<\/option>\n                            <option value=\"Surgery\">Cirurgia<\/option>\n                            <option value=\"Traumatology\">Traumatologia<\/option>\n                            <option value=\"Unknown\">Outro<\/option>\n                        <\/select>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"email\">Endere\u00e7o de e-mail<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"email\" type=\"email\" required\n                        data-pristine-required-message=\"Digite seu endere\u00e7o de e-mail.\"\n                        data-pristine-email-message=\"Esse campo requer um endere\u00e7o de e-mail v\u00e1lido.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"state\">Estado<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"state\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu estado.\">\n                    <\/div>\n\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"accept-ts-cs\" name=\"accept_ts_cs\" required\n                        data-pristine-required-message=\"Por favor, aceite os termos de uso.\">\n                        <label for=\"accept-ts-cs\">Ao marcar a caixa \u00e0 esquerda e clicar em &#8220;Enviar&#8221; abaixo, eu confirmo que tenho pelo menos 18 anos de idade; e confirmo que concordo com a <a href=\"https:\/\/www.biomarin.com\/data-privacy-center\/\" target=\"_blank\">Pol\u00edtica de Privacidade<\/a> e <a href=\"https:\/\/medinfoterms.com\/\" target=\"_blank\">Termos de Uso da BioMarin<\/a>; consinto que a BioMarin, seus sucessores, agentes e\/ou cession\u00e1rios usem o endere\u00e7o de e-mail que forneci para me manter informado sobre atualiza\u00e7\u00f5es de not\u00edcias e desenvolvimentos sobre a PKU; e confirmo que entendo que essas comunica\u00e7\u00f5es\/materiais podem conter informa\u00e7\u00f5es que comercializam ou anunciam produtos, bens ou servi\u00e7os da BioMarin.<span class=\"required\">*<\/span><\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <input type=\"submit\" class=\"button\" value=\"Enviar\">\n                    <\/div>\n                <\/form>\n                <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n            <\/div>\n\n            <div class=\"block form-success-confirmation\" style=\"display:none;\">\n                                    <h3>Muito obrigado!<\/h3>\n<p>Entraremos em contato em breve com informa\u00e7\u00f5es adicionais.<\/p>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09967\" class=\"block references block-tight-top\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Refer\u00eancias:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Vockley J, Andersson HC, Antshel KM, et al; American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guidelines. <em>Genet Med<\/em>. 2014;16(2):188-200.\n<\/span><\/li>\n                                                                                                                                                <li><span>ten Hoedt AE, de Sonneville LMJ, Francois B, et al. High phenylalanine levels directly affect mood and sustained attention in adults with phenylketonuria: a randomised, double-blind, placebo-controlled, crossover trial. <em>J Inherit Metab Dis<\/em>. 2011;34(1):165-171.\n<\/span><\/li>\n                                                                                                                                                <li><span>Trefz KF, Muntau AC, Kohlscheen KM, et al. Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities\u2015a retrospective study of German health insurance claims data. <em>Orphanet J Rare Dis.<\/em> 2019;14(1):181. doi:10.1186\/s13023-019-1153-y.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ashe K, Kelso W, Farrand S, et al. Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. <em>Front Psychiatry<\/em>. 2019;10:561. doi:10.3389\/fpsyt.2019.00561\n<\/span><\/li>\n                                                                                                                                                <li><span>Bilder DA, Kobori JA, Cohen-Pfeffer JL, Johnson EM, Jurecki ER, Grant ML. Neuropsychiatric comorbidities in adults with phenylketonuria: a retrospective cohort study. <em>Mol Genet Metab<\/em>. 2017;12(1):1-8.\n<\/span><\/li>\n                                                                                                                                                <li><span>van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines of phenylketonuria: diagnosis and treatment. <em>Orphanet J Rare Dis<\/em>. 2017;12(1):162. doi: 10.1186\/s13023-017-0685-2.\n<\/span><\/li>\n                                                                                                                                                <li><span>Manti F, Nardecchia F, Chiarotti F, Carducci C, Leuzzi V. Psychiatric disorders in adolescent ad young adult patients with phenylketonuria. <em>Mol Genet Metab<\/em>. 2016;117(1):12-18.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ford S, O\u2019Driscoll M, MacDonald A. Living with phenylketonuria: lessons from the PKU community. <em>Mol Genet Metab Rep<\/em>. 2018;17:57-63.\n<\/span><\/li>\n                                                                                                                                                <li><span>Burton BK, Jones KB, Cederbaum S, et al. Prevalence of comorbid conditions among adult patients diagnosed with phenylketonuria. <em>Mol Genet Metab<\/em>. 2018;125(3):228-234.\n<\/span><\/li>\n                                                                                                                                                <li><span>Brown CS, Lichter-Konecki U. Phenylketonuria (PKU): a problem solved? <em>Mol Genet Metab Rep<\/em>. 2016;6:8-12.\n<\/span><\/li>\n                                                                                                                                                <li><span>Jurecki ER, Cederbaum S, Kopesky J, et al. Adherence to clinic recommendations among patients with phenylketonuria in the United States<em>. Mol Genet Metab<\/em>. 2017;120(3):190-197.\n<\/span><\/li>\n                                                                                                                                                <li><span>van Spronsen FJ, van Wegberg AMJ, Ahring K, et al. Key European guidelines for the diagnosis and management of patients with phenylketonuria. <em>Lancet Diabetes Endocrinol<\/em>. 2017;5(9):743-756.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-272","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Desafios l Consequ\u00eancias da fenilalanina (Phe) elevada no sangue<\/title>\n<meta name=\"description\" content=\"N\u00edveis elevados de fenilalanina (Phe) podem levar a complica\u00e7\u00f5es neurol\u00f3gicas e neuropsicol\u00f3gicas graves, e o 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