{"id":205,"date":"2023-01-11T05:01:13","date_gmt":"2023-01-11T05:01:13","guid":{"rendered":"https:\/\/pkudsehcp-dev-001.azurewebsites.net\/pt-br\/?page_id=205"},"modified":"2024-09-03T10:37:08","modified_gmt":"2024-09-03T10:37:08","slug":"visao-geral","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/pt-br\/pku\/visao-geral\/","title":{"rendered":"O que \u00e9 Fenilceton\u00faria (PKU)? \u2013 Vis\u00e3o Geral"},"content":{"rendered":"<div id=\"acf-block-63f5c128b095a\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/12\/PT-hero-PKU-2000x745-1.jpg?v=0.90);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/03\/hero-815x800.jpg);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>Fenilceton\u00faria: mais do que um dist\u00farbio alimentar, \u00e9 um dist\u00farbio cerebral<sup>1,2<\/sup>\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-63f5c128b26e8\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>Sobre a fenilceton\u00faria (PKU)<\/h2>\n<p>A fenilceton\u00faria (PKU) \u00e9 um erro inato do metabolismo da fenilalanina (Phe), com padr\u00e3o de heran\u00e7a autoss\u00f4mico recessivo, que pode levar a comprometimentos\/consequ\u00eancias significativas no neurodesenvolvimento<sup>1-3<\/sup>.<\/p>\n<ul>\n<li>A PKU \u00e9 caracterizada por uma defici\u00eancia da atividade enzim\u00e1tica da fenilalanina hidroxilase (PAH), resultando em uma incapacidade de metabolizar o amino\u00e1cido Phe<sup>1<\/sup><\/li>\n<li>Se n\u00e3o forem adequadamente controlados, os n\u00edveis elevados de Phe tornam-se neurot\u00f3xicos e desequilibram a neurofisiologia normal<sup>2,3<\/sup><\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/10\/think_icon_with_title_PT.svg\" alt=\"Phe elevado no sangue afeta a maneira como as pessoas com PKU pensam, sentem e agem\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f5c128b2760\" class=\"block split-content equal-bias bg-band bg-band-alternative block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>A PKU \u00e9 diagnosticada por meio de exames em rec\u00e9m-nascidos<\/h2>\n<p>Na Am\u00e9rica Latina, a incid\u00eancia da Fenilceton\u00faria (PKU) \u00e9 de 1 : 24.617 nascidos vivos.<\/p>\n<p><small>Refer\u00eancia:<br \/>\n1. Borrajo, G.J.C. Newborn Screening for Phenylketonuria: Latin American Consensus Guidelines. J. Inborn Errors <em>Metab. Screen. 2016, 4.<\/em><\/small><\/p>\n<p>A PKU pode ser subdiagnosticada, pois alguns pa\u00edses n\u00e3o fazem triagem ou s\u00f3 recentemente adotaram a triagem neonatal.<sup>8,9<\/sup><\/p>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2024\/04\/Prevalence-of-PKU_PT_New.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                                    <figcaption><p><small>Refer\u00eancia:<br \/>\n1. Hillert A, <em>et al<\/em>. Am J Hum Genet. 2020. doi: 10.1016\/j.ajhg.2020.06.006<\/small><\/p>\n<\/figcaption>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f5c128b2781\" class=\"block wrapped-content block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f5c128b2794\" class=\"block-wysiwyg\">\n            <h2>Saiba mais sobre a PKU<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f5c128b27ab\" class=\"block cards cards-2-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f5c128b27c9\" class=\"card card-product card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/03\/phe.svg\" alt=\"Phe\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>A PKU \u00e9 um erro inato do metabolismo da fenilalanina (Phe), com padr\u00e3o de heran\u00e7a autoss\u00f4mico recessivo.\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-arrow\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/genetica-e-fisiopatologia\/\" target=\"_self\">Saiba mais<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f5c128b27f1\" class=\"card card-product card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/wp-content\/uploads\/sites\/4\/2023\/01\/adult_pku_icon_new.svg\" alt=\"Desafios adultos no \u00edcone PKU\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>A PKU em adultos pode apresentar muitos desafios<sup>1,3<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-arrow\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/desafios-do-pku\/\" target=\"_self\">Saiba por qu\u00ea<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"conecte-se-conosco\" class=\"block hcp-sign-up-form\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                            <h2>Mantenha-se conectado com as informa\u00e7\u00f5es mais recentes sobre PKU\n<\/h2>\n                        <div class=\"block form-box\">\n                                    <p>Registre-se abaixo para entrar em contato com um representante da BioMarin, saber mais sobre os pr\u00f3ximos eventos e\/ou not\u00edcias sobre PKU ou solicitar uma discuss\u00e3o entre pares.<\/p>\n<p><strong>* Campos obrigat\u00f3rios<\/strong><\/p>\n                \n                <form id=\"hcp-sign-up\" name=\"Stay connected with the latest PKU information\">\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"connect-local-rep\" name=\"connect_local_rep\">\n                        <label for=\"connect-local-rep\">Conecte-se com um representante local da BioMarin<\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"first-name\">Primeiro nome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"first-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu primeiro nome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"last-name\">Sobrenome<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"last-name\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu sobrenome.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"medical-speciality\">Especialidade<span class=\"required\">*<\/span><\/label>\n                        <select class=\"text\" id=\"medical-speciality\" required\n                        data-pristine-required-message=\"Selecione sua especialidade m\u00e9dica.\">\n                            <option value=\"\">Por favor, selecione<\/option>\n                            <option value=\"Anesthesiology\">Anestesiologia<\/option>\n                            <option value=\"Audiology\">Audiologia<\/option>\n                            <option value=\"Behavioral Neurology &#038; Neuropsychiatry\">Neurologia e Neuropsiquiatria Comportamental<\/option>\n                            <option value=\"Biology\">Biologia<\/option>\n                            <option value=\"Biomedical Engineering\">Engenharia Biom\u00e9dica<\/option>\n                            <option value=\"Cardiology\">Cardiologia<\/option>\n                            <option value=\"Clinical Biochemical Genetics\">Bioqu\u00edmica em Gen\u00e9tica Cl\u00ednica<\/option>\n                            <option value=\"Dentistry and Odontology\">Odontologia<\/option>\n                            <option value=\"Dermatology\">Dermatologia<\/option>\n                            <option value=\"Diagnostic Radiology\">Radiologia Diagn\u00f3stica<\/option>\n                            <option value=\"Electoencephalography\">Eletroencefalografia<\/option>\n                            <option value=\"Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia, Diabetes e Metabolismo<\/option>\n                            <option value=\"ENT\/Otorhinolaryngologist\">Otorrinolaringologista<\/option>\n                            <option value=\"Epileptology\">Epileptologia<\/option>\n                            <option value=\"Gastroenterology\">Gastroenterologia<\/option>\n                            <option value=\"General Practice\/Family\">Cl\u00ednica Geral\/M\u00e9dico de Fam\u00edlia<\/option>\n                            <option value=\"Genetics\">Gen\u00e9tica<\/option>\n                            <option value=\"Hearing and Speech\">Fonoaudiologia<\/option>\n                            <option value=\"Hematology\">Hematologia<\/option>\n                            <option value=\"Hematology &#038; Oncology\">Hematologia e Oncologia<\/option>\n                            <option value=\"Hepatology\">Hepatologia<\/option>\n                            <option value=\"Infectious Diseases\">Infectologia<\/option>\n                            <option value=\"Intensive Care\">Tratamento Intensivo<\/option>\n                            <option value=\"Internal Medicine\">Medicina Interna<\/option>\n                            <option value=\"Kinesiology\">Cinesiologia<\/option>\n                            <option value=\"Laboratory Management\">An\u00e1lises Laboratoriais\/Exames Cl\u00ednicos<\/option>\n                            <option value=\"Medical Student\">Estudante de medicina<\/option>\n                            <option value=\"Neonatology\">Neonatologia<\/option>\n                            <option value=\"Nephrology\">Nefrologia<\/option>\n                            <option value=\"Neurology\">Neurologia<\/option>\n                            <option value=\"Neuromuscular Medicine\">Medicina Neuromuscular<\/option>\n                            <option value=\"Nutrition, Metabolic\">Nutri\u00e7\u00e3o metab\u00f3lica<\/option>\n                            <option value=\"Obstetrics\">Obstetr\u00edcia<\/option>\n                            <option value=\"Occupation Health\">Sa\u00fade Ocupacional<\/option>\n                            <option value=\"Oncology\">Oncologia<\/option>\n                            <option value=\"Ophthalmology\">Oftalmologia<\/option>\n                            <option value=\"Orthopedics\">Ortopedia<\/option>\n                            <option value=\"Paliative\/Hospice\">Paliativo<\/option>\n                            <option value=\"Pediatric Allergy\/Immunology\">Alergia\/Imunologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Anesthesiology\">Anestesiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Cardiology\">Cardiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Dentistry\">Dentista Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Endocrinology\">Endocrinologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Endocrinology, Diabetes &#038; Metabolism\">Endocrinologia Pedi\u00e1trica, Diabetes e Metabolismo<\/option>\n                            <option value=\"Pediatric ENT\">Otorrinolaringologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology\">Gastroenterologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology &#038; Metabolism\">Gastroenterologia Pedi\u00e1trica e Metabolismo<\/option>\n                            <option value=\"Pediatric Genetics\">Gen\u00e9tica Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology\">Hematologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology-Oncology\">Hematologia-Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Metabolism\">Metabolismo Pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Neurology\">Neurologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Neurosurgery\">Neurocirurgia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Oncology\">Oncologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Ophthalmology and Strabismus Specialist\">Especialista em oftalmologia pedi\u00e1trica e estrabismo<\/option>\n                            <option value=\"Pediatric Orthopedics\">Ortopedia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Pneumology\">Pneumologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Radiology\">Radiologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Rheumatology\">Reumatologia Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatrics\">Pediatria<\/option>\n                            <option value=\"Phonoaudiology\">Fonoaudiologia<\/option>\n                            <option value=\"Physiatry\">Fisiatria<\/option>\n                            <option value=\"Physician Assistant\">M\u00e9dico Assistente<\/option>\n                            <option value=\"Physiotherapy\">Fisioterapia<\/option>\n                            <option value=\"Primary Care\">Cuidados Prim\u00e1rios<\/option>\n                            <option value=\"Psychology\/Psychiatry\">Psicologia\/Psiquiatria<\/option>\n                            <option value=\"Pulmonology\">Pneumologia<\/option>\n                            <option value=\"Radiology (MRI imaging)\">Radiologia<\/option>\n                            <option value=\"Research\">Pesquisador<\/option>\n                            <option value=\"Rheumatology\">Reumatologia<\/option>\n                            <option value=\"Surgery\">Cirurgia<\/option>\n                            <option value=\"Traumatology\">Traumatologia<\/option>\n                            <option value=\"Unknown\">Outro<\/option>\n                        <\/select>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"email\">Endere\u00e7o de e-mail<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"email\" type=\"email\" required\n                        data-pristine-required-message=\"Digite seu endere\u00e7o de e-mail.\"\n                        data-pristine-email-message=\"Esse campo requer um endere\u00e7o de e-mail v\u00e1lido.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"state\">Estado<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"state\" type=\"text\" required\n                        data-pristine-required-message=\"Digite seu estado.\">\n                    <\/div>\n\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"accept-ts-cs\" name=\"accept_ts_cs\" required\n                        data-pristine-required-message=\"Por favor, aceite os termos de uso.\">\n                        <label for=\"accept-ts-cs\">Ao marcar a caixa \u00e0 esquerda e clicar em &#8220;Enviar&#8221; abaixo, eu confirmo que tenho pelo menos 18 anos de idade; e confirmo que concordo com a <a href=\"https:\/\/www.biomarin.com\/data-privacy-center\/\" target=\"_blank\">Pol\u00edtica de Privacidade<\/a> e <a href=\"https:\/\/medinfoterms.com\/\" target=\"_blank\">Termos de Uso da BioMarin<\/a>; consinto que a BioMarin, seus sucessores, agentes e\/ou cession\u00e1rios usem o endere\u00e7o de e-mail que forneci para me manter informado sobre atualiza\u00e7\u00f5es de not\u00edcias e desenvolvimentos sobre a PKU; e confirmo que entendo que essas comunica\u00e7\u00f5es\/materiais podem conter informa\u00e7\u00f5es que comercializam ou anunciam produtos, bens ou servi\u00e7os da BioMarin.<span class=\"required\">*<\/span><\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <input type=\"submit\" class=\"button\" value=\"Enviar\">\n                    <\/div>\n                <\/form>\n                <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n            <\/div>\n\n            <div class=\"block form-success-confirmation\" style=\"display:none;\">\n                                    <h3>Muito obrigado!<\/h3>\n<p>Entraremos em contato em breve com informa\u00e7\u00f5es adicionais.<\/p>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f5c128b2854\" class=\"block references block-tight-top\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Refer\u00eancias:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Ashe K, Kelso W, Farrand S, et al. Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. <em>Front Psychiatry<\/em>. 2019;10:561. doi:10.3389\/fpsyt.2019.00561.\n<\/span><\/li>\n                                                                                                                                                <li><span>Gentile JK, Ten Hoedt AE, Bosch AM. Psychosocial aspects of PKU: hidden disabilities\u2014a review<em>. Mol Genet Metab. <\/em>2010;99(suppl 1):S64-S67.\n<\/span><\/li>\n                                                                                                                                                <li><span>Brown CS, Lichter-Konecki U. Phenylketonuria (PKU): a problem solved? <em>Mol Genet Metab Rep<\/em>. 2016;6:8-12.\n<\/span><\/li>\n                                                                                                                                                <li><span>Bilder DA, Noel JK, Baker ER, et al. Systematic review and meta-analysis of neuropsychiatric symptoms and executive functioning in adults with phenylketonuria. <em>Dev Neuropsychol<\/em>. 2016;41(4):245-260.\n<\/span><\/li>\n                                                                                                                                                <li><span>van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines of phenylketonuria: diagnosis and treatment. <em>Orphanet J Rare Dis<\/em>. 2017;12(1):162. doi:10.1186\/s13023-017-0685-2.\n<\/span><\/li>\n                                                                                                                                                <li><span>Vockley J, Andersson HC, Antshel KM, et al; American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guidelines. <em>Genet Med<\/em>. 2014;16(2):188-200.\n<\/span><\/li>\n                                                                                                                                                <li><span>Blau N, van Spronsen FJ, Levy HL. Phenylketonuria. <em>Lancet<\/em>. 2010;376(9750):1417-1427.\n<\/span><\/li>\n                                                                                                                                                <li><span>Pourfarzam M. Fouzieh Z. Newborn screening for inherited metabolic disorders: news and views. <em>J Res Med Sci.<\/em> 2013;18(9):801-808.\n<\/span><\/li>\n                                                                                                                                                <li><span>Rocha JC, MacDonald A. Treatment options and dietary supplements for patients with phenylketonuria. <em>Expert Opin Orphan Drugs<\/em>. 2018;6(11):667-681.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-205","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Vis\u00e3o Geral | Fenilceton\u00faria (PKU): um dist\u00farbio cerebral<\/title>\n<meta name=\"description\" content=\"A fenilceton\u00faria (PKU) \u00e9 um dist\u00farbio metab\u00f3lico autoss\u00f4mico recessivo no qual os n\u00edveis excessivos de fenilalanina (Phe) desequilibram a neurofisiologia normal.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/visao-geral\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vis\u00e3o Geral | Fenilceton\u00faria (PKU): um dist\u00farbio cerebral\" \/>\n<meta property=\"og:description\" content=\"A fenilceton\u00faria (PKU) \u00e9 um dist\u00farbio metab\u00f3lico autoss\u00f4mico recessivo no qual os n\u00edveis excessivos de fenilalanina (Phe) desequilibram a neurofisiologia normal.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hcp.biomarin.com\/pt-br\/pku\/visao-geral\/\" \/>\n<meta property=\"og:site_name\" content=\"BioMarin PKU DSE HCP PT-BR\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-03T10:37:08+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/visao-geral\\\/\",\"url\":\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/visao-geral\\\/\",\"name\":\"Vis\u00e3o Geral | Fenilceton\u00faria (PKU): um dist\u00farbio cerebral\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/#website\"},\"datePublished\":\"2023-01-11T05:01:13+00:00\",\"dateModified\":\"2024-09-03T10:37:08+00:00\",\"description\":\"A fenilceton\u00faria (PKU) \u00e9 um dist\u00farbio metab\u00f3lico autoss\u00f4mico recessivo no qual os n\u00edveis excessivos de fenilalanina (Phe) desequilibram a neurofisiologia normal.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/visao-geral\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/visao-geral\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/visao-geral\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/hcp.biomarin.com\\\/pt-br\\\/pku\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"O que \u00e9 Fenilceton\u00faria (PKU)? 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