{"id":17,"date":"2022-11-03T18:33:55","date_gmt":"2022-11-03T18:33:55","guid":{"rendered":"https:\/\/achdsehcp-dev-001.azurewebsites.net\/en-us\/achondroplasia\/?page_id=17"},"modified":"2024-02-28T14:45:38","modified_gmt":"2024-02-28T14:45:38","slug":"cause","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/cause\/","title":{"rendered":"Cause"},"content":{"rendered":"<div id=\"What-is-achondroplasia\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2022\/11\/Cause_Hero.jpg?v=0.123);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2022\/12\/mobile_bg.png?v=0.123);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>Quelle est la cause de l&rsquo;achondroplasie ?\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Mutation du g\u00e8ne FGFR3<\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"what-is-achon\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab1753b\" class=\"block-wysiwyg\">\n            <h2>L&rsquo;achondroplasie est le type le plus courant de dysplasie squelettique<\/h2>\n<p>L\u2019achondroplasie touche 1 enfant sur 25 000 naissances et concerne environ 250 000 personnes dans le monde.<sup>1,2 <\/sup>L&rsquo;achondroplasia repr\u00e9sente pr\u00e8s de 90 % des cas de petite taille disproportionn\u00e9e (ou nanisme). Elle se caract\u00e9rise par une alt\u00e9ration de la croissance osseuse endochondrale due \u00e0 une mutation gain de fonction au niveau du g\u00e8ne FGFR3 (r\u00e9cepteur 3 du facteur de croissance des fibroblastes) et est associ\u00e9e \u00e0 des caract\u00e9ristiques physiques sp\u00e9cifiques:<sup>1,3-8<\/sup><\/p>\n    <\/div>\n\n<figure id=\"acf-block-63f4e5ab17556\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/08\/Group-245-1900x860.png\" alt=\"Silhouette d&#039;un enfant atteint d&#039;achondroplasie mettant en \u00e9vidence cinq caract\u00e9ristiques physiques cl\u00e9s\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-63f4e5ab17579\" class=\"block-wysiwyg\">\n            <p>Certaines caract\u00e9ristiques physiques, telles que la taille, sont des indicateurs de la croissance osseuse dans l\u2019ensemble du corps<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"endochondral-bone-growth\" class=\"block split-content equal-bias\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                    \n                                    \n                                    <figure>\n                                        <div class=\"image\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/05\/90_icon_2.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h2>Le r\u00e9cepteur FGFR3 exerce une influence sur la croissance osseuse endochondrale dans l&rsquo;ensemble du corps<sup>9<\/sup><\/h2>\n<p><strong>L\u2019ossification endochondrale<\/strong> (remplacement du cartilage par de l\u2019os) concerne l\u2019ensemble du corps et intervient dans le d\u00e9veloppement de pr\u00e8s de <strong>90 % des os<\/strong>. Ce processus d\u00e9bute in utero et se poursuit jusqu\u2019au d\u00e9but de l\u2019\u00e2ge adulte.<sup>10-12<\/sup><\/p>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"endochondral-bone-growth\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17618\" class=\"block-wysiwyg\">\n            <h2>Comprendre la croissance osseuse endochondrale \u00e0 tous les niveaux<\/h2>\n<p>Dans le processus d&rsquo;ossification endochondrale, le pr\u00e9curseur de l&rsquo;os est le cartilage<\/p>\n<h3>Plaque de croissance (<em>sans<\/em> variant pathog\u00e8ne)<sup>9,13,14<\/sup><\/h3>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"new\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2022\/11\/cartilage_growth_plate_1@2x.jpg?v=0.123\" alt=\"Cartilage growth plate\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Le cartilage se compose de chondrocytes et d&rsquo;une matrice extracellulaire<\/li>\n<li>Les chondrocytes jouent un r\u00f4le majeur dans l&rsquo;ossification endochondrale en contribuant directement \u00e0 l&rsquo;allongement des os tout au long de leur d\u00e9veloppement<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"new-2\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2022\/11\/cartilage_growth_plate_2@2x.jpg?v=0.123\" alt=\"Image of cartilage growth plate without achondroplasia\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Les chondrocytes sont issus de la diff\u00e9renciation des cellules m\u00e9senchymateuses embryonnaires<\/li>\n<li>Les chondrocytes prolif\u00e8rent<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"new-3\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2022\/11\/cartilage_growth_plate_3@2x.jpg?v=0.123\" alt=\"Image of cartilage growth plate without achondroplasia\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>La matrice cartilagineuse est s\u00e9cr\u00e9t\u00e9e<\/li>\n<li>Chondrocytes undergo hypertrophy, establishing a new extracellular matrix<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab176df\" class=\"block split-content equal-bias bottom-border block-tight-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>Chondrocytes (sans mutation)<sup>15,16<\/sup><\/h2>\n<ul>\n<li>Deux voies de signalisation jouent un r\u00f4le pr\u00e9pond\u00e9rant dans la r\u00e9gulation de la fonction des chondrocytes<\/li>\n<li>Apr\u00e8s activation, le r\u00e9cepteur FGFR3 envoie un signal pour ralentir la croissance osseuse<\/li>\n<li>La voie CNP (peptide natriur\u00e9tique de type C) neutralise les signaux FGFR3<\/li>\n<li>L&rsquo;activation du r\u00e9cepteur du peptide natriur\u00e9tique B (NPRB) par le CNP bloque le signal FGFR3 pour soutenir la croissance osseuse<\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/06\/chondrocyte-cell-labels-80-crop-2.png?v=0.123\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17704\" class=\"block wrapped-content block-tight-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17716\" class=\"block-wysiwyg\">\n            <p>En raison d\u2019une mutation gain de fonction, le r\u00e9cepteur FGFR3 produit de fa\u00e7on excessive des signaux visant \u00e0 ralentir la croissance osseuse. Submerg\u00e9e par ces signaux, la voie NPRB\/CNP n\u2019est plus capable de les neutraliser, ce qui perturbe la croissance osseuse.<sup>4,16<\/sup><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17740\" class=\"block split-content equal-bias bottom-border block-tight-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h3 style=\"text-align: center\">Voie CNP (<em>sans<\/em> variant pathog\u00e8ne)<\/h3>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/01\/cell1.png?v=0.123\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h3 style=\"text-align: center\">Voie CNP (<em>avec<\/em> variant pathog\u00e8ne)<\/h3>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/08\/Group-246-1900x1628.png\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab1777b\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17789\" class=\"block-wysiwyg\">\n            <h2>Plaques de croissance<\/h2>\n    <\/div>\n\n<figure id=\"acf-block-63f4e5ab1779a\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/08\/Group-249-e1690895564661-1900x1089.png\" alt=\"\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-63f4e5ab177a7\" class=\"block-wysiwyg\">\n            <p>Les r\u00e9percussions sont multisyst\u00e9miques, et les parents n\u2019y sont pas toujours pr\u00e9par\u00e9s<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab177c2\" class=\"block call-to-action\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\" style=\"\">\n\t\t\t\t<div class=\"overlay\"><\/div>\n\t\t\t\t<div class=\"cta-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"cta-content-main\">\n                        <div class=\"content-block\">\n\t\t\t\t\t        \t\t\t\t\t        \t\t\t\t\t\t    \t\t\t\t\t\t        <p>La plupart des parents sont de taille normale. Ils ont donc besoin de votre expertise pour se pr\u00e9parer aux complications multisyst\u00e9miques qui r\u00e9sultent de l\u2019alt\u00e9ration de la croissance osseuse.<sup>4,17<\/sup><\/p>\n\t\t\t\t\t\t    \t\t\t\t\t    <\/div>\n\t\t\t\t\t                                <div class=\"content-block\">\n                                <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/declaration-de-consensus-international\/\" target=\"_self\">Explorer la d\u00e9claration de consensus international<\/a><\/p>\n                            <\/div>\n\t\t\t\t\t                        <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6422fdc5d8590\" class=\"block boxed-content quiz block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"box\">\n\t\t\t\t<div class=\"quiz-question\">\n                    \t\t\t\t\t    <h2>Testez vos connaissances\n<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t    <p>L&rsquo;achondroplasie survient chez environ _________ naissances vivantes dans le monde.<\/p>\n\t\t\t\t\t\n                                            <div class=\"quiz-question-responses\">\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 sur 1,000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"true\">\n                                    1 sur 25 000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 sur 1 000 000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 sur 200 000\n                                <\/a>\n                                                    <\/div>\n\t\t\t\t\t\n                                            <div class=\"quiz-question-submit\">\n                            <p><a class=\"button\" href=\"#\">Soumettre<\/a><\/p>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"quiz-answer\" style=\"display:none;\">\n\t\t\t\t    \t\t\t\t        \t\t\t\t\t    <p class=\"quiz-answer-choice\">Votre choix: %choice%\n<\/p>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t    <div class=\"split-content\">\n                            <div class=\"wrapper\">\n                                <div class=\"inner-wrapper\">\n                                    <div class=\"content-block\">\n                                                                                    <h2 class=\"correct\" style=\"display:none;\">C&rsquo;est exact !\n<\/h2>\n                                        \n                                                                                    <h2 class=\"incorrect\" style=\"display:none;\">Incorrect\u00a0&#8211; La bonne r\u00e9ponse est %answer%\n<\/h2>\n                                        \n                                                                                    <p>L&rsquo;achondroplasie est rare, mais c&rsquo;est le type le plus courant de dysplasie squelettique, affectant 250 000 personnes dans le monde<sup>1<\/sup> et survenant dans environ 1 naissance sur 25 000<sup>2<\/sup>.<\/p>\n                                                                            <\/div>\n                                    <div class=\"content-block\">\n                                                                                    <figure>\n                                                <div class=\"image\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2024\/02\/live_birth_stat_FR-1.png?v=0.123\" alt=\"\" \/>                                                <\/div>\n                                            <\/figure>\n                                                                            <\/div>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\n\t\t\t\t\t                        <p class=\"references\">\n                            <a class=\"quiz-references-modal\" href=\"#quiz-references-modal\">R\u00e9f\u00e9rences<\/a>\n                        <\/p>\n                        <div id=\"quiz-references-modal\" class=\"quiz-references white-popup-block mfp-hide\">\n                            <div class=\"box references\">\n                                <p><a class=\"modal-close\" href=\"#\">Fermer les r\u00e9f\u00e9rences<\/a><\/p>\n                                                                    <h2>R\u00e9f\u00e9rences :\n<\/h2>\n                                                                <ol>\n                                                                                                                                                                                                        <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia.\u202fAppl Clin Genet. 2014;7:117-125. Published 2014 Jun 24. doi:10.2147\/TACG.S51485.\n<\/span><\/li>\n                                                                                                                                                                                                                                                <li><span>Wynn J, King TM, Gambello MJ, Waller DK, Hecht JT. Mortality in achondroplasia study: a 42-year follow-up.\u202fAm J Med Genet A. 2007;143A(21):2502-2511. doi:10.1002\/ajmg.a.31919.\n<\/span><\/li>\n                                                                                                            <\/ol>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab177de\" class=\"block cards cards-2-col\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f4e5ab1781b\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2022\/11\/Impact_Card.jpg?v=0.123\" alt=\"Silhouette of a child with achondroplasia highlighting five key physical characteristics\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Complications de l&rsquo;achondroplasie\n<\/h4>\n        \n                                                                                                            <p>Des complications courantes de l&rsquo;achondroplasie peuvent \u00eatre attendues tout au long de la vie d&rsquo;un individu<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/impact\/\" target=\"_self\">En savoir plus sur les complications de l&rsquo;achondroplasie<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17839\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/wp-content\/uploads\/sites\/3\/2023\/08\/Complications-France-e1691068175317.png?v=0.123\" alt=\"\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Centre de ressources\n<\/h4>\n        \n                                                                                                            <p>Tout ce dont vous avez besoin pour approfondir vos connaissances sur l&rsquo;achondroplasie<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/fr-fr\/achondroplasia\/ressources\/\" target=\"_self\">Acc\u00e9der aux fiches d&rsquo;information et aux ressources sur l&rsquo;achondroplasie<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17897\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>R\u00e9f\u00e9rences:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia. <em>Appl Clin Genet<\/em>. 2014;7:117-125. Published online June 24, 2014.\n<\/span><\/li>\n                                                                                                                                                <li><span>Wynn J, King TM, Gambello MJ, Waller DK, Hecht JT. Mortality in achondroplasia study: a 42-year follow-up. <em>Am J Med Genet A<\/em>. 2007;143A:2502-2511. \n<\/span><\/li>\n                                                                                                                                                <li><span>Waller DK, Correa A, Vo TM, <em>et al<\/em>. The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US. <em>Am J Med Genet A<\/em>. 2008;146A(18):2385-2389.\n<\/span><\/li>\n                                                                                                                                                <li><span>Pauli RM. Achondroplasia: a comprehensive clinical review. <em>Orphanet J Rare Dis<\/em>. 2019;14(1):1. \n<\/span><\/li>\n                                                                                                                                                <li><span>Laederich MB, Horton WA. Achondroplasia: pathogenesis and implications for future treatment. <em>Curr Opin Pediatr<\/em>. 2010;22(4):516-523. \n<\/span><\/li>\n                                                                                                                                                <li><span>Hoover-Fong J, Scott CI, Jones MC; Committee on Genetics. 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Accessed September 4, 2020. https:\/\/embryology.med.unsw.edu.au\/embryology\/index.php\/Musculoskeletal_System_-_Bone_Development_Timeline. \n<\/span><\/li>\n                                                                                                                                                <li><span>Xie Y, Zhou S, Chen H, Du X, Chen L. Recent research on the growth plate: advances in fibroblast growth factor signaling in growth plate development and disorders. <em>J Mol Endocrinol<\/em>. 2014;53(1):T11-T34. \n<\/span><\/li>\n                                                                                                                                                <li><span>Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. <em>J Endocrinol<\/em>. 2011;211(2):109-121. \n<\/span><\/li>\n                                                                                                                                                <li><span>Horton WA, Hall JG, Hecht JT. Achondroplasia. <em>Lancet<\/em>. 2007;370(9582):162-172. \n<\/span><\/li>\n                                                                                                                                                <li><span>Vasques GA, Arnhold IJ, Jorge AA. Role of the natriuretic peptide system in normal growth and growth disorders. <em>Horm Res Paediatr<\/em>. 2014;82(4):222-229.\n<\/span><\/li>\n                                                                                                                                                <li><span>Hecht JT, Bodensteiner JB, Butler IJ. Neurologic manifestations of achondroplasia. <em>Handb Clin Neurol<\/em>. 2014;119:551-563. \n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6422ff85c5c45\" class=\"block print-page\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <p><a class=\"button button-print\" href=\"#\">Imprimer cette page<\/a><\/p>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Qu&#039;est-ce qui cause l&#039;achondroplasie? 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