{"id":272,"date":"2023-01-11T12:19:31","date_gmt":"2023-01-11T12:19:31","guid":{"rendered":"https:\/\/pkudsehcp-dev-001.azurewebsites.net\/es-us\/?page_id=272"},"modified":"2024-09-11T14:36:32","modified_gmt":"2024-09-11T14:36:32","slug":"desafios-de-pku","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/es-la\/pku\/desafios-de-pku\/","title":{"rendered":"Desaf\u00edos de PKU"},"content":{"rendered":"<div id=\"acf-block-63f7515b0910c\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/12\/ES-hero-PKU-2000x745-1.jpg?v=0.90);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/03\/hero-815x800.jpg);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>El impacto de la fenilcetonuria a lo largo de la vida est\u00e1 poco reconocido<sup>1-3<\/sup>\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-63f7515b0914a\" class=\"block wrapped-content bg-band bg-band-alternative block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b09161\" class=\"block-wysiwyg\">\n            <h2>Los niveles elevados de fenilalanina (Phe) pueden derivar en s\u00edntomas graves de fenilcetonuria (PKU)<sup>4-6<\/sup><\/h2>\n    <\/div>\n\n<figure id=\"acf-block-63f7515b0917f\">\n    <div class=\"image image-rounded image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/10\/prevalence_ratios_graph_ES-1.svg\" alt=\"Razones de prevalencia estimadas de diagn\u00f3sticos para pacientes con PKU en comparaci\u00f3n con la imagen de la tabla de la poblaci\u00f3n general\" \/>            <\/div>\n            <figcaption><p><small>Adaptado de Bilder et al. <em>Mol Genet Metab<\/em>. 2017.<\/small><\/p>\n<\/figcaption>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09199\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b091b3\" class=\"block-wysiwyg\">\n            <h2>Los efectos de Phe elevada se sienten durante toda la vida del paciente<sup>1<\/sup><\/h2>\n<ul>\n<li>El control de los niveles de fenilalanina (Phe) en reci\u00e9n nacidos y ni\u00f1os previene la deficiencia intelectual permanente<sup>1,6<\/sup><\/li>\n<li>De todos modos, los adolescentes y adultos con Phe no controlada pueden presentar s\u00edntomas neurol\u00f3gicos, psiqui\u00e1tricos y cognitivos, incluyendo:<sup>6<\/sup><\/li>\n<\/ul>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-647072945ba03\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                    \n                                    \n                                    <figure>\n                                        <div class=\"image\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2024\/07\/heads_left_LAE.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                    \n                                    \n                                    <figure>\n                                        <div class=\"image\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2024\/07\/heads_right_LAE2.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09729\" class=\"block fact-box block-zero-bottom\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t    <h3>Estr\u00e9s mental y emocional de fenilcetonuria<sup>7<\/sup>\n<\/h3>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Incluso los pacientes con Phe en sangre \u2264500 \u00b5mol\/L en la infancia presentaran una frecuencia mayor de diagn\u00f3sticos psiqui\u00e1tricos, tales como<\/p>\n\t\t\t\t\t\t\t\t                    <ul class=\"facts\">\n                                                                                                            <li>Trastorno de ansiedad generalizado\n<\/li>\n                                                                                                            <li>Trastorno depresivo\n<\/li>\n                                                                                                            <li>Trastorno de la personalidad\n<\/li>\n                                                                                                            <li>Problemas de comportamiento\n<\/li>\n                                                                                                            <li>Fobia espec\u00edfica\n<\/li>\n                                                                                                            <li>Mutismo selectivo\n<\/li>\n                                            <\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09764\" class=\"block cards cards-2-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"if-new\" class=\"block wrapped-content block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b0978d\" class=\"block wrapped-content block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b097a1\" class=\"block-wysiwyg\">\n            <h2>Los pacientes y sus cuidadores luchan contra los s\u00edntomas de PKU<sup>8<\/sup><\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b097bd\" class=\"block quote\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"quote-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"content-block\">\n\t\t\t\t\t\t<blockquote>\n\t\t\t\t\t\t    \t\t\t\t\t\t\t    <p>\u00abTengo momentos de vac\u00edo, en que no consigo pensar o decir las palabras que estoy intentando decir. Siento ansiedad y me pongo paranoico\u00bb.<sup>8<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <cite>Paciente con PKU <\/cite>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b097d7\" class=\"block quote\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"quote-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"content-block\">\n\t\t\t\t\t\t<blockquote>\n\t\t\t\t\t\t    \t\t\t\t\t\t\t    <p>Tengo \u00abniebla cerebral\u00bb, tendencia a irritarme y me pongo inquieto en ambientes sociales.\u00bb<sup>8<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <cite>Paciente con PKU <\/cite>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b097ef\" class=\"block quote\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t<div class=\"quote-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"content-block\">\n\t\t\t\t\t\t<blockquote>\n\t\t\t\t\t\t    \t\t\t\t\t\t\t    <p>\u00abCuando uno puede causar da\u00f1o cerebral irreversible a su hijo, eso causa mucha preocupaci\u00f3n, estr\u00e9s y hasta p\u00e1nico.\u00bb<sup>8<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <cite>Padres <\/cite>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09802\" class=\"block wrapped-content bg-band bg-band-alternative block-zero-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b09817\" class=\"block-wysiwyg\">\n            <h2>La carga de PKU va m\u00e1s all\u00e1 del cerebro y se extiende a muchos aspectos de la vida adulta<sup>9<\/sup><\/h2>\n<p>Los adultos con fenilcetonuria (PKU) tienen un mayor riesgo de varias comorbilidades multisist\u00e9micas<sup>9<\/sup><\/p>\n    <\/div>\n\n<figure id=\"acf-block-63f7515b09850\">\n    <div class=\"image image-rounded image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/10\/adjusted_prevalance_table_ES-1.svg\" alt=\"Imagen gr\u00e1fica de la proporci\u00f3n de prevalencia ajustada de afecciones com\u00f3rbidas en pacientes con PKU en comparaci\u00f3n con controles sin PKU\" \/>            <\/div>\n            <figcaption><p><small>Adaptado de Burton et al. <em>Mol Genet Metab<\/em>. 2018.<\/small><\/p>\n<\/figcaption>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09729\" class=\"block fact-box\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\t\t\t\t    <p style=\"text-align: center\"><strong>Los pacientes con PKU luchan para mantener niveles seguros de Phe en sangre<sup>10,11<\/sup><\/strong><\/p>\n\t\t\t\t\t\t\t\t                    <ul class=\"facts\">\n                                                                                                            <li>Una dieta con restricciones de Phe es compleja y proporciona una ingesta inadecuada de prote\u00ednas\n<\/li>\n                                                                                                            <li>El control de Phe normalmente cae durante la adolescencia\n<\/li>\n                                                                                                            <li>En la edad adulta, la mayor\u00eda de los pacientes en los Estados Unidos y Europa tienen niveles de Phe que exceden las recomendaciones de las directrices\n<\/li>\n                                            <\/ul>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09897\" class=\"block wrapped-content block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f7515b098a6\" class=\"block-wysiwyg\">\n            <h2 class=\"p1\">Conozca m\u00e1s sobre PKU<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"learn-more-about-PKU\" class=\"block cards cards-3-col block-tight-top block-tight-bottom\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f7515b098d9\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/01\/dietry_control.svg\" alt=\"Control diet\u00e9tico con icono de PKU\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Conozca m\u00e1s sobre el control de la dieta con PKU<sup>1<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/dieta-para-pku\/\" target=\"_self\">Ir a Dieta para PKU<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b098f7\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/01\/guidelines.svg\" alt=\"Icono de rango de Phe por encima del objetivo\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>67% de los adultos con PKU est\u00e1n por encima de los rangos de Phe recomendados<sup>11<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/necesidad-no-atendida\/\" target=\"_self\">Sepa por qu\u00e9<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b0990f\" class=\"card card-product card-fixed-button card-centered\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/wp-content\/uploads\/sites\/6\/2023\/01\/management.svg\" alt=\"Icono de opciones de gesti\u00f3n de PKU\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Conozca las opciones de control de la PKU\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/es-la\/pku\/opciones-de-tratamiento-de-la-pku\/\" target=\"_self\">Explorar<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"Mant\u00e9ngase-actualizado\" class=\"block hcp-sign-up-form\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                            <h2>Mant\u00e9ngase actualizado con la informaci\u00f3n m\u00e1s recientes sobre PKU\n<\/h2>\n                        <div class=\"block form-box\">\n                                    <p>Reg\u00edstrese abajo para entrar en contacto con un representante de BioMarin, conozca m\u00e1s sobre los pr\u00f3ximos eventos y noticias sobre PKU o solicitar una conversaci\u00f3n entre pares.<\/p>\n<p><strong>* Campos obligatorios<\/strong><\/p>\n                \n                <form id=\"hcp-sign-up\" name=\"Stay connected with the latest PKU information\">\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"connect-local-rep\" name=\"connect_local_rep\">\n                        <label for=\"connect-local-rep\">Con\u00e9ctese con un representante local de BioMarin<\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"first-name\">Primer nombre<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"first-name\" type=\"text\" required\n                        data-pristine-required-message=\"Ingrese su primer nombre.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"last-name\">Apellido<span class=\"required\">*<\/span><\/label>\n                        <input class=\"text\" id=\"last-name\" type=\"text\" required\n                        data-pristine-required-message=\"Ingrese su apellido.\">\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <label for=\"medical-speciality\">Especialidad<span class=\"required\">*<\/span><\/label>\n                        <select class=\"text\" id=\"medical-speciality\" required\n                        data-pristine-required-message=\"Seleccione su especialidad m\u00e9dica.\">\n                            <option value=\"\">Por favor, seleccione su especialidad m\u00e9dica<\/option>\n                            <option value=\"Anesthesiology\">Anestesiolog\u00eda<\/option>\n                            <option value=\"Audiology\">Audiolog\u00eda<\/option>\n                            <option value=\"Behavioral Neurology &#038; Neuropsychiatry\">Neurolog\u00eda del Comportamiento y Neuropsiquiatr\u00eda<\/option>\n                            <option value=\"Biology\">Biolog\u00eda<\/option>\n                            <option value=\"Biomedical Engineering\">Ingenier\u00eda Biom\u00e9dica<\/option>\n                            <option value=\"Cardiology\">Cardiolog\u00eda<\/option>\n                            <option value=\"Clinical Biochemical Genetics\">Gen\u00e9tica Bioqu\u00edmica Cl\u00ednica<\/option>\n                            <option value=\"Dentistry and Odontology\">Odontolog\u00eda<\/option>\n                            <option value=\"Dermatology\">Dermatolog\u00eda<\/option>\n                            <option value=\"Diagnostic Radiology\">Radiolog\u00eda diagn\u00f3stica<\/option>\n                            <option value=\"Electoencephalography\">Electroencefalograf\u00eda<\/option>\n                            <option value=\"Endocrinology, Diabetes &#038; Metabolism\">Endocrinolog\u00eda, Diabeter y Metabolismo<\/option>\n                            <option value=\"ENT\/ Otorhinolaryngologist\">Otorrinolaring\u00f3logo<\/option>\n                            <option value=\"Epileptology\">Epileptolog\u00eda<\/option>\n                            <option value=\"Gastroenterology\">Gastroenterolog\u00eda<\/option>\n                            <option value=\"General Practice\/Family\">Cl\u00ednica general\/familiar<\/option>\n                            <option value=\"Genetics\">Gen\u00e9tica<\/option>\n                            <option value=\"Hearing and Speech\">Terapia del lenguaje<\/option>\n                            <option value=\"Hematology\">Hematolog\u00eda<\/option>\n                            <option value=\"Hematology&#038;Oncology\">Hematolog\u00eda y Oncolog\u00eda<\/option>\n                            <option value=\"Hepatology\">Hepatolog\u00eda<\/option>\n                            <option value=\"Infectious Diseases\">Enfermedades infecciosas<\/option>\n                            <option value=\"Intensive Care\">Tratamiento intensivo<\/option>\n                            <option value=\"Internal Medicine\">Medicina Interna<\/option>\n                            <option value=\"Kinesiology\">Kinesiolog\u00eda<\/option>\n                            <option value=\"Laboratory Management\">Gesti\u00f3n de laboratorio<\/option>\n                            <option value=\"Medical Student\">Estudiante de medicina<\/option>\n                            <option value=\"Neonatology\">Neonatolog\u00eda<\/option>\n                            <option value=\"Nephrology\">Nefrolog\u00eda<\/option>\n                            <option value=\"Neurology\">Neurolog\u00eda<\/option>\n                            <option value=\"Neuromuscular Medicine\">Medicina neuromuscular<\/option>\n                            <option value=\"Nutrition, Metabolic\">Nutrici\u00f3n metab\u00f3lica<\/option>\n                            <option value=\"Nutritionist\">Nutricionista<\/option>\n                            <option value=\"Obstetrics\">Obstetricia<\/option>\n                            <option value=\"Occupation Health\">Salud ocupacional<\/option>\n                            <option value=\"Oncology\">Oncolog\u00eda<\/option>\n                            <option value=\"Ophthalmology\">Oftalmolog\u00eda<\/option>\n                            <option value=\"Orthopedics\">Ortoped\u00eda<\/option>\n                            <option value=\"Paliative\/Hospice\">Paliativo<\/option>\n                            <option value=\"Pediatric Allergy\/Immunology\">Alergia\/Inmunolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Anesthesiology\">Anestesiolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Cardiology\">Cardiolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Dentistry\">Odont\u00f3logo pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Endocrinology\">Endocrinolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Endocrinology, Diabetes &#038; Metabolism\">Endocrinolog\u00eda Pedi\u00e1trica, Diabetes y Metabolismo<\/option>\n                            <option value=\"Pediatric ENT\">Otorrinolaringolog\u00eda pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology\">Gastroenterolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Gastroenterology &#038; Metabolism\">Gastroenterolog\u00eda y metabolismo pedi\u00e1tricos<\/option>\n                            <option value=\"Pediatric Genetics\">Gen\u00e9tica pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology\">Hematolog\u00eda pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Hematology-Oncology\">Hematolog\u00eda-Oncolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Metabolism\">Metabolismo pedi\u00e1trico<\/option>\n                            <option value=\"Pediatric Neurology\">Neurolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Neurosurgery\">Neurocirug\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Oncology\">Oncolog\u00eda Pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric Ophthalmology and Strabismus Specialist\">Especialista en oftalmolog\u00eda pedi\u00e1trica y estrabismo<\/option>\n                            <option value=\"Pediatric Orthopedics\">Ortopedia pedi\u00e1trica<\/option>\n                            <option value=\"Pediatric 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De acuerdo con la Pol\u00edtica de Privacidad de BioMarin, sus Datos Personales se mantendr\u00e1n seguros, de acuerdo con las leyes y regulaciones aplicables, y podr\u00e1n usarse para (i) invitarlo a participar en programas que BioMarin desarrolla por s\u00ed mismo y\/o junto con sus socios, (ii) realizar actividades relacionadas con el objeto social de BioMarin, (iii) realizar estudios epidemiol\u00f3gicos e investigaciones de resultados, (iv) comunicar informaci\u00f3n sobre enfermedades del portafolio de BioMarin, (v) comunicar informaci\u00f3n sobre los productos de BioMarin a profesionales de la salud a trav\u00e9s de nuestros representantes de ventas o equipo m\u00e9dico, nuestros sitios web, correo electr\u00f3nico, centros de llamadas, correo postal y otros canales, incluidas comunicaciones y otras promociones de marketing, seg\u00fan corresponda, (vi) realizar simposios, conferencias y otros programas educativos y cient\u00edficos, de BioMarin mismo o de terceros; y (vii) realizar estudios de mercado. Si tiene alguna pregunta sobre el procesamiento de sus datos personales o desea ejercer sus derechos, comun\u00edquese con BioMarin a trav\u00e9s del correo electr\u00f3nico <a href=\"mailto:LATAMDataPrivacy@ bmrn.com\">LATAMDataPrivacy@bmrn.com<\/a>.<span class=\"required\">*<\/span><\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <input type=\"submit\" class=\"button\" value=\"Enviar\">\n                    <\/div>\n                <\/form>\n                <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n            <\/div>\n\n            <div class=\"block form-success-confirmation\" style=\"display:none;\">\n                                    <h3>\u00a1Muchas gracias!<\/h3>\n<p>En breve nos pondremos en contacto con informaci\u00f3n adicional.<\/p>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f7515b09967\" class=\"block references block-tight-top\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Referencias:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Vockley J, Andersson HC, Antshel KM, et al; American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guidelines. <em>Genet Med<\/em>. 2014;16(2):188-200.\n<\/span><\/li>\n                                                                                                                                                <li><span>ten Hoedt AE, de Sonneville LMJ, Francois B, et al. High phenylalanine levels directly affect mood and sustained attention in adults with phenylketonuria: a randomised, double-blind, placebo-controlled, crossover trial. <em>J Inherit Metab Dis<\/em>. 2011;34(1):165-171.\n<\/span><\/li>\n                                                                                                                                                <li><span>Trefz KF, Muntau AC, Kohlscheen KM, et al. Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities\u2015a retrospective study of German health insurance claims data. <em>Orphanet J Rare Dis.<\/em> 2019;14(1):181. doi:10.1186\/s13023-019-1153-y.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ashe K, Kelso W, Farrand S, et al. Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. <em>Front Psychiatry<\/em>. 2019;10:561. doi:10.3389\/fpsyt.2019.00561\n<\/span><\/li>\n                                                                                                                                                <li><span>Bilder DA, Kobori JA, Cohen-Pfeffer JL, Johnson EM, Jurecki ER, Grant ML. Neuropsychiatric comorbidities in adults with phenylketonuria: a retrospective cohort study. <em>Mol Genet Metab<\/em>. 2017;12(1):1-8.\n<\/span><\/li>\n                                                                                                                                                <li><span>van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines of phenylketonuria: diagnosis and treatment. <em>Orphanet J Rare Dis<\/em>. 2017;12(1):162. doi: 10.1186\/s13023-017-0685-2.\n<\/span><\/li>\n                                                                                                                                                <li><span>Manti F, Nardecchia F, Chiarotti F, Carducci C, Leuzzi V. Psychiatric disorders in adolescent ad young adult patients with phenylketonuria. <em>Mol Genet Metab<\/em>. 2016;117(1):12-18.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ford S, O\u2019Driscoll M, MacDonald A. Living with phenylketonuria: lessons from the PKU community. <em>Mol Genet Metab Rep<\/em>. 2018;17:57-63.\n<\/span><\/li>\n                                                                                                                                                <li><span>Burton BK, Jones KB, Cederbaum S, et al. Prevalence of comorbid conditions among adult patients diagnosed with phenylketonuria. <em>Mol Genet Metab<\/em>. 2018;125(3):228-234.\n<\/span><\/li>\n                                                                                                                                                <li><span>Brown CS, Lichter-Konecki U. Phenylketonuria (PKU): a problem solved? <em>Mol Genet Metab Rep<\/em>. 2016;6:8-12.\n<\/span><\/li>\n                                                                                                                                                <li><span>Jurecki ER, Cederbaum S, Kopesky J, et al. Adherence to clinic recommendations among patients with phenylketonuria in the United States<em>. Mol Genet Metab<\/em>. 2017;120(3):190-197.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-272","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Consecuencias de la Phe elevada en sangre l Fenilcetonuria (PKU)<\/title>\n<meta name=\"description\" content=\"Los niveles elevados de fenilalanina (Phe) pueden derivar en complicaciones neurol\u00f3gicas y neuropsicol\u00f3gicas graves, y la carga a lo largo de la vida es poco reconocida.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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