{"id":17,"date":"2022-11-03T18:33:55","date_gmt":"2022-11-03T18:33:55","guid":{"rendered":"https:\/\/achdsehcp-dev-001.azurewebsites.net\/en-us\/achondroplasia\/?page_id=17"},"modified":"2024-09-03T11:12:34","modified_gmt":"2024-09-03T11:12:34","slug":"causa","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/causa\/","title":{"rendered":"Causa"},"content":{"rendered":"<div id=\"What-is-achondroplasia\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2022\/11\/Cause_Hero.jpg?v=0.122);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2022\/12\/mobile_bg.png?v=0.122);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>\u00bfQu\u00e9 causa la acondroplasia?\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Mutaci\u00f3n del gen FGFR3<\/p>\n<p>La acondroplasia ocurre en 1 de cada 25.000 nacidos vivos y afecta a alrededor de 250.000 personas en todo el mundo<sup>1,2<\/sup><\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"what-is-achon\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab1753b\" class=\"block-wysiwyg\">\n            <h2>La acondroplasia es tipo m\u00e1s com\u00fan de displasia esquel\u00e9tica<\/h2>\n<p>La acondroplasia representa casi el 90% de la estatura baja desproporcionada o talla baja. Caracterizada por un crecimiento \u00f3seo endocondral deficiente, es causada por una variante patog\u00e9nica de ganancia de funci\u00f3n en el gen del receptor 3 del factor de crecimiento de fibroblastos (FGFR3) y tiene caracter\u00edsticas f\u00edsicas distintas<sup>1,3-8<\/sup><\/p>\n    <\/div>\n\n<figure id=\"acf-block-63f4e5ab17556\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2024\/08\/boy_with_labels-ES-US-2.svg\" alt=\"\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-63f4e5ab17579\" class=\"block-wysiwyg\">\n            <p>Las caracter\u00edsticas f\u00edsicas, como la altura, son indicadores del crecimiento \u00f3seo en todo el cuerpo.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"endochondral-bone-growth\" class=\"block split-content equal-bias\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                    \n                                    \n                                    <figure>\n                                        <div class=\"image\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2023\/05\/90_icon_2.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h2>FGFR3 afecta el crecimiento del hueso endocondral en todo el cuerpo<sup>9<\/sup><\/h2>\n<p>La osificaci\u00f3n endocondral, la sustituci\u00f3n del cart\u00edlago por hueso, se produce en todo el cuerpo y participa en el desarrollo de aproximadamente el 90% de todos los huesos. Este proceso comienza en el \u00fatero y contin\u00faa hasta la edad adulta temprana.<sup>10-12<\/sup><\/p>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"endochondral-bone-growth\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17618\" class=\"block-wysiwyg\">\n            <h2>Comprenda el crecimiento \u00f3seo endocondral en todos los niveles<\/h2>\n<p>En la osificaci\u00f3n endocondral, el precursor del futuro hueso es el cart\u00edlago.<\/p>\n<h3>Placa de crecimiento del cart\u00edlago (sin variante pat\u00f3gena) <sup>9,13,14<\/sup><\/h3>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"new\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2022\/11\/cartilage_growth_plate_1@2x.jpg?v=0.122\" alt=\"Cartilage growth plate\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>El cart\u00edlago est\u00e1 compuesto de condrocitos y matriz extracelular<\/li>\n<li>Los condrocitos desempe\u00f1an un papel clave en la osificaci\u00f3n endocondral, contribuyendo directamente al alargamiento de los huesos durante todo el desarrollo<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"new-2\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2022\/11\/cartilage_growth_plate_2@2x.jpg?v=0.122\" alt=\"Image of cartilage growth plate without achondroplasia\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                \n<ul>\n<li>Los condrocitos resultan de la diferenciaci\u00f3n de c\u00e9lulas mesenquimales embrionarias<\/li>\n<li>Los condrocitos experimentan proliferaci\u00f3n<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"new-3\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2022\/11\/cartilage_growth_plate_3@2x.jpg?v=0.122\" alt=\"Image of cartilage growth plate without achondroplasia\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Se secreta matriz de cart\u00edlago<\/li>\n<li>Los condrocitos se hipertrofian, estableciendo una nueva matriz extracelular<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab176df\" class=\"block split-content equal-bias bottom-border block-tight-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>V\u00eda de condrocitos y CNP (sin variante patog\u00e9nica)<sup>15,16<\/sup><\/h2>\n<ul>\n<li>Dos v\u00edas de se\u00f1alizaci\u00f3n desempe\u00f1an un papel importante en la regulaci\u00f3n de funci\u00f3n de los condrocitos<\/li>\n<li>Se\u00f1ales de activaci\u00f3n de FGFR3 para retardar el crecimiento \u00f3seo<\/li>\n<li>La v\u00eda del CNP (p\u00e9ptido natriur\u00e9tico tipo C) contrarresta las se\u00f1ales de FGFR3<\/li>\n<li>La activaci\u00f3n del receptor B del p\u00e9ptido natriur\u00e9tico (NPRB) por el CNP bloquea la se\u00f1al de FGFR3 para sostener el crecimiento \u00f3seo<\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2024\/08\/chondrocyte-cell-esus-2.png?v=0.122\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17704\" class=\"block wrapped-content block-tight-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17716\" class=\"block-wysiwyg\">\n            <p>La variante patog\u00e9nica de ganancia de funci\u00f3n hace que FGFR3 genere excesivamente se\u00f1ales para ralentizar el crecimiento \u00f3seo, lo que anula la se\u00f1alizaci\u00f3n que contrarresta la v\u00eda NPRB\/CNP y provoca un crecimiento \u00f3seo deficiente. <sup>4,16<\/sup><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17740\" class=\"block split-content equal-bias bottom-border block-tight-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h3 style=\"text-align: center\">V\u00eda CNP (sin variante patog\u00e9nica)<\/h3>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2023\/01\/cell1.png?v=0.122\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h3 style=\"text-align: center\">V\u00eda CNP (con variante patog\u00e9nica)<\/h3>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2024\/07\/cell_label.-ES-US.png?v=0.122\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab1777b\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17789\" class=\"block-wysiwyg\">\n            <h2>Placas de crecimiento de cart\u00edlago<\/h2>\n    <\/div>\n\n<figure id=\"acf-block-63f4e5ab1779a\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2024\/07\/Cartilage-growth-plates-ES-US.svg\" alt=\"\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-63f4e5ab177a7\" class=\"block-wysiwyg\">\n            <p>La mayor\u00eda de padres son de estatura promedio, lo cual significa que puede requerir de su experiencia para prepararlos para las posibles complicaciones causadas por el crecimiento de hueso deficiente \u2074\u207b\u00b9\u2077<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6422fdc5d8590\" class=\"block boxed-content quiz block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"box\">\n\t\t\t\t<div class=\"quiz-question\">\n                    \t\t\t\t\t    <h2>Pruebe sus conocimientos\n<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t    <p>La acondroplasia ocurre en aproximadamente _________ nacidos vivos en todo el mundo.<\/p>\n\t\t\t\t\t\n                                            <div class=\"quiz-question-responses\">\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 en 1.000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"true\">\n                                    1 en 25.000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 en 1.000.000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 en 200.000\n                                <\/a>\n                                                    <\/div>\n\t\t\t\t\t\n                                            <div class=\"quiz-question-submit\">\n                            <p><a class=\"button\" href=\"#\">Enviar<\/a><\/p>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"quiz-answer\" style=\"display:none;\">\n\t\t\t\t    \t\t\t\t        \t\t\t\t\t    <p class=\"quiz-answer-choice\">Usted elegi\u00f3: %choice%\n<\/p>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t    <div class=\"split-content\">\n                            <div class=\"wrapper\">\n                                <div class=\"inner-wrapper\">\n                                    <div class=\"content-block\">\n                                                                                    <h2 class=\"correct\" style=\"display:none;\">\u00a1As\u00ed es!\n<\/h2>\n                                        \n                                                                                    <h2 class=\"incorrect\" style=\"display:none;\">Incorrecto &#8211; La respuesta correcta es %answer%\n<\/h2>\n                                        \n                                                                                    <p>La acondroplasia es poco frecuente, pero es el tipo m\u00e1s com\u00fan de displasia esquel\u00e9tica, afecta a 250.000 personas en todo el mundo<sup>1<\/sup> y ocurre en aproximadamente 1 de cada 25.000 nacidos vivos.<sup>2<\/sup><\/p>\n                                                                            <\/div>\n                                    <div class=\"content-block\">\n                                                                                    <figure>\n                                                <div class=\"image\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2024\/07\/live_births-ES-US_3.png?v=0.122\" alt=\"\" \/>                                                <\/div>\n                                            <\/figure>\n                                                                            <\/div>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\n\t\t\t\t\t                        <p class=\"references\">\n                            <a class=\"quiz-references-modal\" href=\"#quiz-references-modal\">Referencias<\/a>\n                        <\/p>\n                        <div id=\"quiz-references-modal\" class=\"quiz-references white-popup-block mfp-hide\">\n                            <div class=\"box references\">\n                                <p><a class=\"modal-close\" href=\"#\">Close references<\/a><\/p>\n                                                                    <h2>Referencias:\n<\/h2>\n                                                                <ol>\n                                                                                                                                                                                                        <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia.\u202fAppl Clin Genet. 2014;7:117-125. Published 2014 Jun 24. doi:10.2147\/TACG.S51485.\n<\/span><\/li>\n                                                                                                                                                                                                                                                <li><span>Wynn J, King TM, Gambello MJ, Waller DK, Hecht JT. Mortality in achondroplasia study: a 42-year follow-up.\u202fAm J Med Genet A. 2007;143A(21):2502-2511. doi:10.1002\/ajmg.a.31919.\n<\/span><\/li>\n                                                                                                            <\/ol>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab177de\" class=\"block cards cards-2-col\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f4e5ab1781b\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2022\/11\/Impact_Card.jpg?v=0.122\" alt=\"Silhouette of a child with achondroplasia highlighting five key physical characteristics\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Complicaciones de la acondroplasia\n<\/h4>\n        \n                                                                                                            <p>Se pueden esperar complicaciones comunes de la acondroplasia a lo largo de la vida de un individuo.<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/complicaciones\/\" target=\"_self\">M\u00e1s informaci\u00f3n sobre las complicaciones de la acondroplasia<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17839\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/wp-content\/uploads\/sites\/12\/2024\/07\/Complication-Timeline-Resource-Group-4070_2X-B-ES@1x.png?v=0.122\" alt=\"\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Biblioteca de recursos\n<\/h4>\n        \n                                                                                                            <p>Todo lo que necesita para profundizar sus conocimientos sobre la acondroplasia<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/es-la\/achondroplasia\/recursos\/\" target=\"_self\">Acceda a nuestros recursos<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17897\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Referencias:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia. <em>Appl Clin Genet<\/em>. 2014;7:117-125. Published online June 24, 2014.\n<\/span><\/li>\n                                                                                                                                                <li><span>Wynn J, King TM, Gambello MJ, Waller DK, Hecht JT. Mortality in achondroplasia study: a 42-year follow-up. <em>Am J Med Genet A<\/em>. 2007;143A:2502-2511. \n<\/span><\/li>\n                                                                                                                                                <li><span>Waller DK, Correa A, Vo TM, <em>et al<\/em>. The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US. <em>Am J Med Genet A<\/em>. 2008;146A(18):2385-2389.\n<\/span><\/li>\n                                                                                                                                                <li><span>Pauli RM. Achondroplasia: a comprehensive clinical review. <em>Orphanet J Rare Dis<\/em>. 2019;14(1):1. \n<\/span><\/li>\n                                                                                                                                                <li><span>Laederich MB, Horton WA. Achondroplasia: pathogenesis and implications for future treatment. <em>Curr Opin Pediatr<\/em>. 2010;22(4):516-523. \n<\/span><\/li>\n                                                                                                                                                <li><span>Hoover-Fong J, Scott CI, Jones MC; Committee on Genetics. Health supervision for people with achondroplasia. <em>Pediatrics<\/em>. 2020;145(6):e20201010. \n<\/span><\/li>\n                                                                                                                                                <li><span>Chilbule SK, Dutt V, Madjhuri V. Limb lengthening in achondroplasia. <em>Indian J Orthop<\/em>. 2016;50(4):397-405. \n<\/span><\/li>\n                                                                                                                                                <li><span>Hoover-Fong J, Schulze KJ, McGready J, Barnes H, Scott CI. Age-appropriate body mass index in children with achondroplasia: interpretation in relation to indexes of height. <em>Am J Clin Nutr<\/em>. 2008;88:364-371. \n<\/span><\/li>\n                                                                                                                                                <li><span>Matsushita T, Wilcox WR, Chan YY, <em>et al<\/em>. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. <em>Hum Mol Genet<\/em>. 2009;18(2):227-240. \n<\/span><\/li>\n                                                                                                                                                <li><span>Berendsen AD, Olsen BR. Bone development. Bone. 2015;80:14-18.\n<\/span><\/li>\n                                                                                                                                                <li><span> Clarke B. Normal bone anatomy and physiology. <em>Clin J Am Soc Nephrol<\/em>. 2008;3(Suppl 3):S131-S139. \n<\/span><\/li>\n                                                                                                                                                <li><span> Hill MA. Musculoskeletal system &#8211; bone development timeline. Embryology. June 19, 2020. Accessed September 4, 2020. https:\/\/embryology.med.unsw.edu.au\/embryology\/index.php\/Musculoskeletal_System_-_Bone_Development_Timeline. \n<\/span><\/li>\n                                                                                                                                                <li><span>Xie Y, Zhou S, Chen H, Du X, Chen L. Recent research on the growth plate: advances in fibroblast growth factor signaling in growth plate development and disorders. <em>J Mol Endocrinol<\/em>. 2014;53(1):T11-T34. \n<\/span><\/li>\n                                                                                                                                                <li><span>Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. <em>J Endocrinol<\/em>. 2011;211(2):109-121. \n<\/span><\/li>\n                                                                                                                                                <li><span>Horton WA, Hall JG, Hecht JT. Achondroplasia. <em>Lancet<\/em>. 2007;370(9582):162-172. \n<\/span><\/li>\n                                                                                                                                                <li><span>Vasques GA, Arnhold IJ, Jorge AA. Role of the natriuretic peptide system in normal growth and growth disorders. <em>Horm Res Paediatr<\/em>. 2014;82(4):222-229.\n<\/span><\/li>\n                                                                                                                                                <li><span>Hecht JT, Bodensteiner JB, Butler IJ. Neurologic manifestations of achondroplasia. <em>Handb Clin Neurol<\/em>. 2014;119:551-563. \n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6422ff85c5c45\" class=\"block print-page\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <p><a class=\"button button-print\" href=\"#\">Imprima esta p\u00e1gina<\/a><\/p>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u00bfQu\u00e9 causa la acondroplasia? 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