{"id":17,"date":"2022-11-03T18:33:55","date_gmt":"2022-11-03T18:33:55","guid":{"rendered":"https:\/\/achdsehcp-dev-001.azurewebsites.net\/en-us\/achondroplasia\/?page_id=17"},"modified":"2024-05-16T11:04:55","modified_gmt":"2024-05-16T11:04:55","slug":"causa","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/causa\/","title":{"rendered":"Causa"},"content":{"rendered":"<div id=\"hero\" class=\"hero hero-no-overlay hero-large-first-para\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2022\/11\/Cause_Hero.jpg?v=0.122);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2022\/12\/mobile_bg.png?v=0.122);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>\u00bfCu\u00e1l es la causa de la acondroplasia?\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Una mutaci\u00f3n del gen <em>FGFR3<\/em><\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"que-es-la-acondroplasia\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab1753b\" class=\"block-wysiwyg\">\n            <h2>La acondroplasia se produce en 1 de cada 25.000 reci\u00e9n nacidos vivos y afecta a unas 250.000 personas en todo el mundo<sup>1,2<\/sup><\/h2>\n<p>La acondroplasia es el tipo m\u00e1s com\u00fan de displasia esquel\u00e9tica y supone casi el 90% de casos de baja estatura desproporcionada o enanismo. Est\u00e1 causada por una mutaci\u00f3n de ganancia de funci\u00f3n en el gen del receptor 3 del factor de crecimiento de fibroblastos <em>(FGFR3)<\/em>, se caracteriza por un retraso en el crecimiento \u00f3seo endocondral y posee unas caracter\u00edsticas f\u00edsicas distintivas:<sup>1,3-8<\/sup><\/p>\n    <\/div>\n\n<figure id=\"acf-block-63f4e5ab17556\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/08\/Group-245-1900x860.png\" alt=\"\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-63f4e5ab17579\" class=\"block-wysiwyg\">\n            <p>Ciertas caracter\u00edsticas f\u00edsicas, como la altura, son indicadores del crecimiento \u00f3seo en el cuerpo<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"crecimiento-\u00f3seo-endocondral\" class=\"block split-content equal-bias\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                    \n                                    \n                                    <figure>\n                                        <div class=\"image\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/05\/90_icon_2.svg\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h2>El FGFR3 regula el crecimiento \u00f3seo endocondral en todo el cuerpo<sup>9<\/sup><\/h2>\n<p>La\u00a0<strong>osificaci\u00f3n endocondral<\/strong>\u00a0(la sustituci\u00f3n de cart\u00edlago por hueso) tiene lugar en todo el cuerpo e interviene en el desarrollo de aproximadamente\u00a0<strong>el\u00a090% de los huesos<\/strong>. Este proceso se inicia en el \u00fatero y continua hasta el inicio de la edad adulta.<sup>10-12<\/sup><\/p>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"crecimiento-\u00f3seo-endocondral2\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17618\" class=\"block-wysiwyg\">\n            <h2>Comprender el crecimiento \u00f3seo endocondral en cada fase<\/h2>\n<p>En la osificaci\u00f3n endocondral, el precursor del futuro hueso es el cart\u00edlago<\/p>\n<h3>Placa de crecimiento del cart\u00edlago<\/h3>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"new\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2022\/11\/cartilage_growth_plate_1@2x.jpg?v=0.122\" alt=\"Cartilage growth plate\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>El cart\u00edlago est\u00e1 formado por condrocitos y una matriz extracelular<\/li>\n<li>Los condrocitos tienen una funci\u00f3n esencial en la osificaci\u00f3n endocondral y contribuyen directamente a la elongaci\u00f3n de los huesos durante el desarrollo<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"new-2\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2022\/11\/cartilage_growth_plate_2@2x.jpg?v=0.122\" alt=\"Image of cartilage growth plate without achondroplasia\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Los condrocitos se originan por diferenciaci\u00f3n de las c\u00e9lulas mesenquimatosas embrionarias<\/li>\n<li>Los condrocitos proliferan<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"new-3\" class=\"block split-content equal-bias bottom-border block-tight-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2022\/11\/cartilage_growth_plate_3@2x.jpg?v=0.122\" alt=\"Image of cartilage growth plate without achondroplasia\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Se secreta la matriz del cart\u00edlago<\/li>\n<li>Los condrocitos se hipertrofian, estableciendo una nueva matriz extracelular<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab176df\" class=\"block split-content equal-bias bottom-border block-tight-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2>Condrocitos y via de se\u00f1alizaci\u00f3n del CNP (sin variante patog\u00e9nica) <sup>15,16<\/sup><\/h2>\n<ul>\n<li>Hay dos v\u00edas de se\u00f1alizaci\u00f3n celular que desempe\u00f1an un importante papel en la regulaci\u00f3n de la funci\u00f3n de los condrocitos<\/li>\n<li>La activaci\u00f3n del FGFR3 ralentiza el crecimiento \u00f3seo<\/li>\n<li>La v\u00eda del CNP (p\u00e9ptido natriur\u00e9tico tipo C) contrarresta las se\u00f1ales de <em>FGFR3<\/em><\/li>\n<li>La activaci\u00f3n del receptor B del p\u00e9ptido natriur\u00e9tico (NPRB) por CNP bloquea la se\u00f1al FGFR3 para mantener el crecimiento \u00f3seo<\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/06\/chondrocyte-cell-labels-80-crop-2.png?v=0.122\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17704\" class=\"block wrapped-content block-tight-top block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17716\" class=\"block-wysiwyg\">\n            <p>La mutaci\u00f3n de ganancia de funci\u00f3n hace que el FGFR3 genere se\u00f1ales de forma excesiva para ralentizar el crecimiento \u00f3seo, de manera que supera la se\u00f1alizaci\u00f3n opuesta de la v\u00eda del NPR-B\/CNP y provoca un retraso en el crecimiento \u00f3seo.<sup>4,16<\/sup><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17740\" class=\"block split-content equal-bias bottom-border block-tight-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h3 style=\"text-align: center\">Regulaci\u00f3n CNP (sin variante patog\u00e9nica)<\/h3>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/01\/cell1.png?v=0.122\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h3 style=\"text-align: center\">Regulaci\u00f3n CNP (con variante patog\u00e9nica)<\/h3>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/08\/Group-246-1900x1628.png\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab1777b\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-63f4e5ab17789\" class=\"block-wysiwyg\">\n            <h2>Placas de crecimiento del cart\u00edlago<\/h2>\n    <\/div>\n\n<figure id=\"acf-block-63f4e5ab1779a\">\n    <div class=\"image image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2024\/03\/variante_patogenica.png?v=0.122\" alt=\"\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-63f4e5ab177a7\" class=\"block-wysiwyg\">\n            <p>Esto tiene un efecto multisist\u00e9mico para el que los padres pueden no estar preparados<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-64c95ecdaf06f\" class=\"block boxed-content quiz block-tight-top block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"box\">\n\t\t\t\t<div class=\"quiz-question\">\n                    \t\t\t\t\t    <h2>Prueba tus conocimientos\n<\/h2>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t    <p>La acondroplasia ocurre en aproximadamente _________ nacidos vivos en todo el mundo.<\/p>\n\t\t\t\t\t\n                                            <div class=\"quiz-question-responses\">\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 de cada 1.000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"true\">\n                                    1 de cada 25.000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 de cada 1.000.000\n                                <\/a>\n                                                                                                                                                            <a class=\"button button-ghost\" href=\"#\" data-correct-answer=\"false\">\n                                    1 de cada 200000\n                                <\/a>\n                                                    <\/div>\n\t\t\t\t\t\n                                            <div class=\"quiz-question-submit\">\n                            <p><a class=\"button\" href=\"#\">Enviar<\/a><\/p>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"quiz-answer\" style=\"display:none;\">\n\t\t\t\t    \t\t\t\t        \t\t\t\t\t    <p class=\"quiz-answer-choice\">Tu elegiste: %choice%\n<\/p>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t    <div class=\"split-content\">\n                            <div class=\"wrapper\">\n                                <div class=\"inner-wrapper\">\n                                    <div class=\"content-block\">\n                                                                                    <h2 class=\"correct\" style=\"display:none;\">Correcto!\n<\/h2>\n                                        \n                                                                                    <h2 class=\"incorrect\" style=\"display:none;\">Eso no es correcto &#8211; La respuesta correcta es %answer%\n<\/h2>\n                                        \n                                                                                    <p>La acondroplasia es rara, pero es el tipo m\u00e1s com\u00fan de displasia esquel\u00e9tica, afecta a 250 000 personas en todo el mundo<sup>1<\/sup> y ocurre en aproximadamente 1 de cada 25 000 nacidos vivos<sup>2<\/sup>.<\/p>\n                                                                            <\/div>\n                                    <div class=\"content-block\">\n                                                                                    <figure>\n                                                <div class=\"image\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/12\/live_birth_stat_ES.png?v=0.122\" alt=\"\" \/>                                                <\/div>\n                                            <\/figure>\n                                                                            <\/div>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\n\t\t\t\t\t                        <p class=\"references\">\n                            <a class=\"quiz-references-modal\" href=\"#quiz-references-modal\">References<\/a>\n                        <\/p>\n                        <div id=\"quiz-references-modal\" class=\"quiz-references white-popup-block mfp-hide\">\n                            <div class=\"box references\">\n                                <p><a class=\"modal-close\" href=\"#\">Close references<\/a><\/p>\n                                                                    <h2>References:\n<\/h2>\n                                                                <ol>\n                                                                                                                                                                                                        <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia.\u202fAppl Clin Genet. 2014;7:117-125. Published 2014 Jun 24. doi:10.2147\/TACG.S51485.\n<\/span><\/li>\n                                                                                                                                                                                                                                                <li><span>Wynn J, King TM, Gambello MJ, Waller DK, Hecht JT. Mortality in achondroplasia study: a 42-year follow-up.\u202fAm J Med Genet A. 2007;143A(21):2502-2511. doi:10.1002\/ajmg.a.31919.\n<\/span><\/li>\n                                                                                                            <\/ol>\n                            <\/div>\n                        <\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab177de\" class=\"block cards cards-2-col\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-63f4e5ab1781b\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2022\/11\/Impact_Card.jpg?v=0.122\" alt=\"Silhouette of a child with achondroplasia highlighting five key physical characteristics\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Complicaciones de la acondroplasia\n<\/h4>\n        \n                                                                                                            <p>Se pueden esperar complicaciones comunes de la acondroplasia a lo largo de la vida de un individuo.<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/impacto\/\" target=\"_self\">M\u00e1s informaci\u00f3n sobre las complicaciones de la acondroplasia<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17839\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/wp-content\/uploads\/sites\/5\/2023\/08\/Complications-Spain-e1691483115345.png?v=0.122\" alt=\"\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Biblioteca de recursos\n<\/h4>\n        \n                                                                                                            <p>Todo lo que necesitas para profundizar en tus conocimientos sobre la acondroplasia<\/p>\n                                                                                                                                                                                                                                                                        \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/es-es\/achondroplasia\/recursos\/\" target=\"_self\">Acceda a hojas informativas y recursos sobre la acondroplasia<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-63f4e5ab17897\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>Bibliograf\u00eda: \n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia. <em>Appl Clin Genet.<\/em> 2014;7:117-125. Published online Jun 24, 2014\n<\/span><\/li>\n                                                                                                                                                <li><span>Wynn J, King TM, Gambello MJ, Waller DK, Hecht JT. Mortality in achondroplasia study: a 42-year follow-up. <em>Am J Med Genet A.<\/em> 2007;143A:2502\u20132511.\n<\/span><\/li>\n                                                                                                                                                <li><span>Waller DK, Correa A, Vo TM, et al. The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US. <em>Am J Med Genet A.<\/em> 2008;146A(18):2385-2389.\n<\/span><\/li>\n                                                                                                                                                <li><span>Pauli RM. Achondroplasia: a comprehensive clinical review. <em>Orphanet J Rare Dis<\/em>. 2019;14(1):1.\n<\/span><\/li>\n                                                                                                                                                <li><span>Laederich MB, Horton WA. Achondroplasia: pathogenesis and implications for future treatment. <em>Curr Opin Pediatr<\/em>. 2010;22(4):516-523.\n<\/span><\/li>\n                                                                                                                                                <li><span>Hoover-Fong J, Scott CI, Jones MC; Committee on Genetics. Health supervision for people with achondroplasia. <em>Pediatrics<\/em>. 2020;145(6):e20201010.\n<\/span><\/li>\n                                                                                                                                                <li><span>Chilbule SK, Dutt V, Madjhuri V. Limb lengthening in achondroplasia. <em>Indian J Orthop<\/em>. 2016;50(4):397-405.\n<\/span><\/li>\n                                                                                                                                                <li><span>Hoover-Fong J, Schulze KJ, McGready J, Barnes H, Scott CI. Age-appropriate body mass index in children with achondroplasia: interpretation in relation to indexes of height. <em>Am J Clin Nutr<\/em>. 2008;88:364 -71.\n<\/span><\/li>\n                                                                                                                                                <li><span>Matsushita T, Wilcox WR, Chan YY, et al. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. <em>Hum Mol Genet<\/em>. 2009;18(2):227-240.\n<\/span><\/li>\n                                                                                                                                                <li><span>Berendsen AD, Olsen BR. Bone development. <em>Bone<\/em>. 2015;80:14-18.\n<\/span><\/li>\n                                                                                                                                                <li><span>Clarke B. Normal bone anatomy and physiology. Clin J <em>Am Soc Nephrol<\/em>. 2008;3(Suppl 3):S131-S139.\n<\/span><\/li>\n                                                                                                                                                <li><span>Hill MA. Musculoskeletal system &#8211; bone development timeline. <em>Embryology<\/em>. June 19, 2020. Accessed September 4, 2020. https:\/\/embryology.med.unsw.edu.au\/embryology\/index.php\/Musculoskeletal_System_-_Bone_Development_Timeline.\n<\/span><\/li>\n                                                                                                                                                <li><span>Xie Y, Zhou S, Chen H, Du X, Chen L. Recent research on the growth plate: advances in fibroblast growth factor signaling in growth plate development and disorders. <em>J Mol Endocrinol<\/em>. 2014;53(1):T11-T34.\n<\/span><\/li>\n                                                                                                                                                <li><span>Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. <em>J Endocrinol<\/em>. 2011;211(2):109-121.\n<\/span><\/li>\n                                                                                                                                                <li><span>Horton WA, Hall JG, Hecht JT. Achondroplasia. <em>Lancet<\/em>. 2007;370(9582):162-172.\n<\/span><\/li>\n                                                                                                                                                <li><span>Vasques GA, Arnhold IJ, Jorge AA. Role of the natriuretic peptide system in normal growth and growth disorders. <em>Horm Res Paediatr<\/em>. 2014;82(4):222-229.\n<\/span><\/li>\n                                                                                                                                                <li><span>Hecht JT, Bodensteiner JB, Butler IJ. Neurologic manifestations of achondroplasia. <em>Handb Clin Neurol<\/em>. 2014;119:551-563.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6422ff85c5c45\" class=\"block print-page\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <p><a class=\"button button-print\" href=\"#\">Imprime esta p\u00e1gina<\/a><\/p>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u00bfQu\u00e9 causa la acondroplasia? 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