{"id":59,"date":"2022-11-28T20:52:54","date_gmt":"2022-11-28T20:52:54","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/voxzogo2\/?page_id=59"},"modified":"2026-05-19T14:33:23","modified_gmt":"2026-05-19T14:33:23","slug":"how-voxzogo-works","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/voxzogo\/how-voxzogo-works\/","title":{"rendered":"How VOXZOGO Works"},"content":{"rendered":"
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Only VOXZOGO promotes endochondral bone growth as early as birth1<\/sup><\/h1>\n <\/div>\n\n
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Target the underlying cause of achondroplasia1,2<\/sup><\/h3>\n

VOXZOGO targets the cell signaling imbalance in achondroplasia by mimicking the body’s natural CNP<\/strong> to improve the balance and increase linear growth.1,2<\/sup><\/p>\n

Learn more about the impact of VOXZOGO.1<\/sup><\/p>\n

Download Brochure<\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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This graphic is an illustration of the cell signaling imbalance in achondroplasia and how VOXZOGO is designed to improve the balance. This graphic is not to scale and does not reflect a percentage growth.<\/p>\n

CNP,<\/strong> C-type natriuretic peptide; FGFR3,<\/strong> fibroblast growth factor receptor 3.<\/p>\n<\/figcaption>\n <\/figure>\n <\/div>\n <\/div>\n<\/div>\n\n

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Watch how VOXZOGO targets overactive FGFR3 signaling to promote bone growth1<\/sup><\/h3>\n <\/div>\n \t\t<\/div>\n\t<\/div>\n<\/div>\n\n
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International consensus guidelines provide a practical framework for clinicians treating with VOXZOGO5<\/sup>\n<\/h2>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Developed by 16 international experts (14 clinical experts, 2 patient representatives; 5 from the US). BioMarin provided funding for this project, including to the participants. BioMarin was not involved in the selection of the guidelines development group, defining the guidelines scope, the voting process, analysis of the results, or preparation of the submitted manuscript. Please see Acknowledgements section of publication for additional detail.5<\/sup><\/p>\n

View Guidelines<\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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These guidelines provide recommendations across the treatment pathway, from before starting treatment to ongoing monitoring5<\/sup>:<\/span><\/h3>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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These are select sections of a few recommendations for the use of VOXZOGO (vosoritide) in clinical practice. The guidelines publication should be reviewed in its entirety along with the VOXZOGO Prescribing Information.1,5<\/sup><\/p>\n

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Prescribed to 5,000+ infants and children with achondroplasia worldwide1,6<\/sup>\n<\/h2>\n\t\t\t\t\t\t \t\t\t\t\t\t \t\t\t\t\t\t

Hear from real families who have chosen treatment with VOXZOGO.1<\/sup><\/p>\n\t\t\t\t\t\t \t\t\t\t\t <\/div>\n\t\t\t\t\t

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Explore Patient Stories<\/a><\/p>\n <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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References:\n<\/h4>\n\t\t\t\t\t\t
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  1. VOXZOGO [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2024.\n<\/span><\/li>\n
  2. Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet<\/em>. 2007;370(9582):162-172.\n<\/span><\/li>\n
  3. Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. J Endocrinol.<\/em> 2011;211(2):109-121.\n<\/span><\/li>\n
  4. Breeland G, Sinkler MA, Menezes RG. Embryology, bone ossification. In: StatPearls. StatPearls Publishing; 2023. Accessed March 17, 2026. \u2028https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539718\/\n<\/span><\/li>\n
  5. Savarirayan R, Hoover-Fong J, Ozono K, et al. International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia. Nat Rev Endocrinol.<\/em> 2025;21(5):314-324.\n<\/span><\/li>\n
  6. Data on file [1]. BioMarin Pharmaceutical Inc; 2025.\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-59","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nHow VOXZOGO\u00ae Works | VOXZOGO\u00ae (vosoritide) HCP<\/title>\n<meta name=\"description\" content=\"Learn more about how VOXZOGO works for your infant and children patients with achondroplasia.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/voxzogo\/how-voxzogo-works\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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