{"id":59,"date":"2022-11-28T20:52:54","date_gmt":"2022-11-28T20:52:54","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/voxzogo2\/?page_id=59"},"modified":"2026-08-26T06:20:39","modified_gmt":"2026-08-26T06:20:39","slug":"how-voxzogo-works","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/voxzogo\/how-voxzogo-works\/","title":{"rendered":"How VOXZOGO Works"},"content":{"rendered":"
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Only VOXZOGO is FDA approved to promote endochondral bone growth as early as birth1<\/sup><\/h1>\n <\/div>\n\n
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Target the underlying cause of achondroplasia1,2<\/sup><\/h3>\n

VOXZOGO targets the cell signaling imbalance in achondroplasia by mimicking the body’s natural CNP to improve the balance and increase linear growth<\/strong>.1,2<\/sup><\/p>\n

Learn more about the impact of VOXZOGO.1<\/sup><\/p>\n

Download Brochure<\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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This graphic is an illustration of the cell signaling imbalance in achondroplasia and how VOXZOGO is designed to improve the balance. This graphic is not to scale and does not reflect a percentage growth.<\/p>\n

CNP,<\/strong> C-type natriuretic peptide; FGFR3,<\/strong> fibroblast growth factor receptor 3.<\/p>\n<\/figcaption>\n <\/figure>\n <\/div>\n <\/div>\n<\/div>\n\n

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Watch how VOXZOGO improves the balance of cell signaling to promote bone growth1<\/sup><\/h3>\n <\/div>\n \t\t<\/div>\n\t<\/div>\n<\/div>\n\n
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“We knew there was a limited time frame on how much growth she really has, which helped us make our decision to treat early.”<\/h3>\n

\u2013 Julie, Eve\u2019s mom<\/p>\n \t\t<\/div>\n\t<\/div>\n\t

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International consensus guidelines provide a practical framework for clinicians treating with VOXZOGO5<\/sup>\n<\/h2>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Developed by 16 international experts (14 clinical experts, 2 patient representatives; 5 from the US). BioMarin provided funding for this project, including to the participants. BioMarin was not involved in the selection of the guidelines development group, defining the guidelines scope, the voting process, analysis of the results, or preparation of the submitted manuscript. Please see Acknowledgements section of the 2025 publication for additional detail.5<\/sup><\/p>\n

View Guidelines<\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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These guidelines provide recommendations across the treatment pathway, from before starting treatment to ongoing monitoring5<\/sup>:<\/span><\/h3>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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These are select sections of a few recommendations for the use of VOXZOGO in clinical practice. The guidelines publication should be reviewed in its entirety along with the VOXZOGO Prescribing Information.1,5<\/sup><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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Prescribed to 5,000+ infants and children with achondroplasia worldwide1,6<\/sup>\n<\/h2>\n\t\t\t\t\t\t \t\t\t\t\t\t \t\t\t\t\t\t

Hear from real families who have chosen treatment with VOXZOGO.1<\/sup><\/p>\n\t\t\t\t\t\t \t\t\t\t\t <\/div>\n\t\t\t\t\t

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Explore Patient Stories<\/a><\/p>\n <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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References:\n<\/h4>\n\t\t\t\t\t\t
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  1. VOXZOGO [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2024.\n<\/span><\/li>\n
  2. Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet<\/em>. 2007;370(9582):162-172.\n<\/span><\/li>\n
  3. Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. J Endocrinol.<\/em> 2011;211(2):109-121.\n<\/span><\/li>\n
  4. Breeland G, Sinkler MA, Menezes RG. Embryology, bone ossification. In: StatPearls. StatPearls Publishing; 2023. Accessed March 17, 2026. \u2028https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539718\/\n<\/span><\/li>\n
  5. Savarirayan R, Hoover-Fong J, Ozono K, et al. International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia. Nat Rev Endocrinol.<\/em> 2025;21(5):314-324.\n<\/span><\/li>\n
  6. Data on file [1]. BioMarin Pharmaceutical Inc; 2025.\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-59","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nHow Does VOXZOGO\u00ae Work in Achondroplasia? | Mechanism of Action<\/title>\n<meta name=\"description\" content=\"Learn how VOXZOGO\u00ae (vosoritide) can improve the balance of cell signaling to promote bone growth from birth in children with achondroplasia and open growth plates.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/voxzogo\/how-voxzogo-works\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Does VOXZOGO\u00ae Work in Achondroplasia? 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