{"id":5773,"date":"2026-04-15T19:32:29","date_gmt":"2026-04-15T19:32:29","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/voxzogo\/?page_id=5773"},"modified":"2026-05-19T18:26:13","modified_gmt":"2026-05-19T18:26:13","slug":"care-from-birth","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/voxzogo\/care-from-birth\/","title":{"rendered":"Care From Birth"},"content":{"rendered":"
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Achondroplasia is often diagnosed prenatally or at birth1,2<\/sup><\/h1>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Support better management from day 1 with proactive and multidisciplinary care3,4<\/sup><\/h4>\n

Achondroplasia is characterized by inhibited endochondral bone growth throughout the body, which can impact physical development, especially early in life.4-9<\/sup> By age 2, children with achondroplasia achieve more than half their adult height.10<\/sup>*<\/strong><\/p>\n

Learn more about your role in providing specialized and timely care for your patients.4<\/sup><\/p>\n

Download Brochure<\/a><\/p>\n <\/div>\n \t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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Helping families navigate an achondroplasia diagnosis3,4,11<\/sup><\/h2>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Congratulate and reassure parents<\/strong><\/h5>\n

on their new child, while\u2028helping them to feel optimistic about the prognosis3,4<\/sup><\/p>\n

See Real Stories<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Educate on achondroplasia<\/strong><\/h5>\n

including potential health impacts and importance of proactive care3,4<\/sup><\/p>\n

Learn More<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Inform on the care path<\/strong><\/h5>\n

by outlining relevant specialists and management options from birth3,4,11<\/sup><\/p>\n

Explore Treatment<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Connect to specialized care<\/strong><\/h5>\n

through timely referrals to healthcare providers with achondroplasia experience3,4<\/sup><\/p>\n

Find Local Doctors<\/a><\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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The most rapid growth occurs in the first 2 years of life12,13<\/sup><\/h2>\n <\/div>\n\n
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*Based on stature-for-age data (birth to 18 years old) from CLARITY, an achondroplasia natural history study comprising measurements from 549 males and 502 females with achondroplasia.10<\/sup><\/small><\/p>\n<\/figcaption>\n <\/figure>\n <\/div>\n <\/div>\n<\/div>\n\n

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Monitor for potential multisystemic skeletal complications as early as possible4,9<\/sup><\/h2>\n

Many complications that can have serious health impacts are more common in the first 2 years of life<\/strong>.4,8,9,15<\/sup><\/p>\n

VOXZOGO has been approved to increase linear growth in children with achondroplasia.1<\/sup> Proactive and multidisciplinary care can help inform management and treatment approaches, which are important for multisystemic complications.3,4<\/sup><\/p>\n <\/div>\n \n

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Early multidisciplinary care is critical3,4<\/sup><\/h2>\n

Due to the multisystemic and lifelong effects of achondroplasia, it’s important that individuals with achondroplasia receive proactive and multidisciplinary care,<\/strong> especially early in life. Timely and experienced care is essential to support positive patient outcomes.3,4<\/sup><\/p>\n <\/div>\n\n

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5,000+ families of infants and children with achondroplasia have chosen treatment worldwide23<\/sup>\n<\/h2>\n\t\t\t\t\t\t \t\t\t\t\t\t \t\t\t\t\t\t

Learn about the 10+ years of clinical trial data with a dedicated BioMarin representative.24<\/sup><\/p>\n\t\t\t\t\t\t \t\t\t\t\t <\/div>\n\t\t\t\t\t

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Connect Now<\/a><\/p>\n <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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References:\n<\/h4>\n\t\t\t\t\t\t
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  1. Hoover-Fong JE, Alade AY, Hashmi SS, et al. Achondroplasia Natural History Study (CLARITY): a multicenter retrospective cohort study of achondroplasia in the United States. Genet Med.<\/em> 2021;23(8):1498-1505.\n<\/span><\/li>\n
  2. Cormier-Daire V, AlSayed M, Alves I, et al. Optimising the diagnosis and referral of achondroplasia in Europe: European Achondroplasia Forum best practice recommendations. Orphanet J Rare Dis.<\/em> 2022;17(1):293.\n<\/span><\/li>\n
  3. Hoover-Fong J, Scott CI, Jones MC; Committee on Genetics. Health supervision for people with achondroplasia. Pediatrics<\/em>. 2020;145(6):e20201010.\n<\/span><\/li>\n
  4. Savarirayan R, Ireland P, Irving M, et al. International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia. Nat Rev Endocrinol.<\/em> 2022;18(3):173-189.\n<\/span><\/li>\n
  5. Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet<\/em>. 2007;370(9582):162-172.\n<\/span><\/li>\n
  6. Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. J Endocrinol.<\/em> 2011;211(2):109-121.\n<\/span><\/li>\n
  7. Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol<\/em>. 2008;3(suppl 3):S131-S139.\n<\/span><\/li>\n
  8. Witt S, Rohenkohl A, Bullinger M, et al. Understanding, assessing and improving health-related quality of life of young people with achondroplasia \u2010<\/span> a collaboration between a patient organization and academic medicine. Pediatr Endocrinol Rev<\/em>. 2017;15(suppl 1):109-118.\n<\/span><\/li>\n
  9. Hoover-Fong J, Cheung MS, Fano V, et al. Lifetime impact of achondroplasia: current evidence and perspectives on the natural history. Bone<\/em>. 2021;146:115872.\n<\/span><\/li>\n
  10. Hoover-Fong JE, Schulze KJ, Alade AY, et al. Growth in achondroplasia including stature, weight, weight-for-height and head circumference from CLARITY: achondroplasia natural history study\u2014a multi-center retrospective cohort study of achondroplasia in the US. Orphanet J Rare Dis.<\/em>\n2021;16(1):522.\n<\/span><\/li>\n
  11. Savarirayan R, Hoover-Fong J, Ozono K, et al. International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia. Nat Rev Endocrinol.<\/em> 2025;21(5):314-324.\n<\/span><\/li>\n
  12. Merker A, Neumeyer L, Hertel NT, et al. Growth in achondroplasia: development of height, weight, head circumference, and body mass index in a European cohort. Am J Med Genet A.<\/em> 2018;176(8):1723-1734.\n<\/span><\/li>\n
  13. Hoover-Fong JE, Schulze KJ, McGready J, et al. Age-appropriate body mass index in children with achondroplasia: interpretation in relation to indexes of height. Am J Clin Nutr.<\/em> 2008;88(2):364-371.\n<\/span><\/li>\n
  14. Kvist O, Dallora AL, Nilsson O, et al. A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults. Acta Paediatr.<\/em> 2021;110(4):1249-1256.\n<\/span><\/li>\n
  15. Brinkmann G, Schlitt H, Zorowka P, Spranger J. Cognitive skills in achondroplasia. Am J Med Genet.<\/em> 1993;47(5):800-804.\n<\/span><\/li>\n
  16. Berendsen AD, Olsen BR. Bone development. Bone<\/em>. 2015;80:14-18.\n<\/span><\/li>\n
  17. Hsieh YL, Wei X, Wang Y, et al. Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses. Bone<\/em>. 2021;153:116142.\n<\/span><\/li>\n
  18. Musculoskeletal Key. Cranial and pelvic \u201cvertebrae\u201d are they real vertebrae? Accessed March 17, 2026. https:\/\/musculoskeletalkey.com\/cranial-and-pelvic-vertebrae-are-they-real-vertebrae\/\n<\/span><\/li>\n
  19. Young M, Selleri L, Capellini TD. Genetics of scapula and pelvis development: an evolutionary perspective. Curr Top Dev Biol<\/em>. 2019;132:311-349.\n<\/span><\/li>\n
  20. Yu M, Wang SM. Anatomy, head and neck, ethmoid bone. In: StatPearls. StatPearls Publishing; 2023. Accessed March 17, 2026. \u2028https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544328\/\n<\/span><\/li>\n
  21. \u00c7ankaya H, Egeli E, Kutluhan A, Kiri\u015f M. Pneumatization of the concha inferior as a cause of nasal obstruction. Rhinology<\/em>. 2001;39(2):109-111.\n<\/span><\/li>\n
  22. Mitomo K, Matsunaga S, Kitamura K, et al. Sphenoid bone hypoplasia is a skeletal phenotype of cleidocranial dysplasia in a mouse model and patients. Bone<\/em>. 2019;120:176-186.\n<\/span><\/li>\n
  23. Data on file [1]. BioMarin Pharmaceutical Inc; 2025.\n<\/span><\/li>\n
  24. ClinicalTrials.gov. Search: Achondroplasia, BioMarin Pharmaceutical. Accessed March 17, 2026. https:\/\/www.clinicaltrials.gov\/search?cond=Achondroplasia&term=BioMarin%20Pharmaceutical&viewType=Table\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n

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