{"id":952,"date":"2022-09-13T10:23:42","date_gmt":"2022-09-13T10:23:42","guid":{"rendered":"https:\/\/vimizimhcp-dev-001.azurewebsites.net\/en-us\/vimizim\/?page_id=952"},"modified":"2023-05-03T11:41:22","modified_gmt":"2023-05-03T11:41:22","slug":"natural-history","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/natural-history\/","title":{"rendered":"Natural History"},"content":{"rendered":"<div id=\"acf-block-643e6f8194328\" class=\"page-header\">         \n            \n        <div class=\"header-image\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/vimizim\/wp-content\/uploads\/sites\/2\/2022\/09\/Nick2.png?v=0.46)\"><\/div>\n     \n    <div class=\"header-content\">\n                    <h1>Morquio A is a multisystemic, progressive disorder<sup>1<\/sup><\/h1>\n            <\/div>\n<\/div>\n\n<div id=\"acf-block-643e6f81969ff\" class=\"block split-content equal-bias\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h2 class=\"h3\">Progressive impairment of endurance and decline in pulmonary performance are characteristic symptoms of Morquio A<sup>1,2<\/sup><\/h2>\n<p>A natural history study of Morquio A demonstrated continued decline in endurance and pulmonary function.<sup>2<\/sup> A subanalysis of the natural history study included patients who met the VIMIZIM<sup>\u00ae<\/sup> (elosulfase alfa) phase 3 trial inclusion criteria (\u22655 years of age with a baseline 6-minute walk test [6MWT] of \u226530 m and \u2264325 m).<sup>2<\/sup><\/p>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/wp-content\/uploads\/sites\/2\/2022\/08\/Group-6-3.png?v=0.46\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-643e6f8196a41\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-643e6f8196aa1\" class=\"block split-content equal-bias content-align-top\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <h3><strong>Progressive impact on endurance:<\/strong><\/h3>\n<p><strong>Least squares mean 6MWT changes from baseline for Morquio A Clinical Assessment Program (MorCAP) subjects<sup>2<\/sup><\/strong><\/p>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/wp-content\/uploads\/sites\/2\/2023\/01\/Screenshot-2023-01-23-at-20.08.42-e1674504738822.png?v=0.46\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h3>Progressive impact on pulmonary function:<\/h3>\n<p><strong>Least squares mean maximum voluntary ventilation (MVV) from baseline in patients &gt;14 years<sup>2<\/sup><\/strong><\/p>\n                                                                                                                                                                                                                                                                                                                    \n                                    \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-rounded\">\n                                                                                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/wp-content\/uploads\/sites\/2\/2023\/01\/Screenshot-2023-01-23-at-20.08.49.png?v=0.46\" alt=\"\" \/>                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-643e6f8196ad9\" class=\"block boxed-content boxed-content-white\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\">\n\t\t\t\t\t\t\t\t\n<div id=\"acf-block-643e6f8196aff\" class=\"image-text-block content-align-center\">\n        <div class=\"content-block\">\n                                                    <p><a class=\"button button-text button-arrow\" href=\"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/about-vimizim\/\" target=\"_self\">Review the mechanism of action and more information about VIMIZIM<\/a><\/p>\n                        <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-643e6f8196b1c\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>References:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Harmatz P, Mengel KE, Giugliani R, <em>et al<\/em>. The Morquio A Clinical Assessment Program: baseline results illustrating progressive, multisystemic clinical impairments in Morquio A subjects. <em>Mol Genet Metab<\/em>. 2013;109(1):54-61.\n<\/span><\/li>\n                                                                                                                                                <li><span>Harmatz P, Mengel KE, Giugliani R, <em>et al<\/em>. Longitudinal analysis of endurance and respiratory function from a natural history study of Morquio A syndrome. <em>Mol Genet Metab<\/em>. 2015;114(2):186-194.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-952","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Morquio A Natural History Study | VIMIZIM\u00ae (elosulfase alfa)<\/title>\n<meta name=\"description\" content=\"A natural history study of Morquio A demonstrated continued decline in endurance and pulmonary function. 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