{"id":948,"date":"2022-09-13T10:22:30","date_gmt":"2022-09-13T10:22:30","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/?page_id=948"},"modified":"2026-04-02T06:04:34","modified_gmt":"2026-04-02T06:04:34","slug":"disease-progression","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/vimizim\/disease-progression\/","title":{"rendered":"Disease Progression"},"content":{"rendered":"
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Morquio A can progress to serious complications regardless of phenotype1<\/sup><\/h1>\n <\/div>\n<\/div>\n\n
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GAG accumulation can lead to progressive organ damage2<\/sup><\/h2>\n

Recognize the signs and symptoms of Morquio A, a multi-systemic genetic condition3,4<\/sup><\/h3>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Neurological Complications\n<\/h2>\n <\/div>\n
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Cervical myelopathy, cervical spinal instability, spinal cord compression3<\/sup><\/p>\n <\/div>\n <\/div>\n

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Ear, Nose, and Throat Issues\n<\/h2>\n <\/div>\n
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Conductive and sensorineural hearing loss, airway obstruction3<\/sup><\/p>\n <\/div>\n <\/div>\n

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Gastrointestinal Issues\n<\/h2>\n <\/div>\n
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Mild hepatosplenomegaly, hernias, loose stools, diarrhea, constipation, abdominal pain2,5,6<\/sup><\/p>\n <\/div>\n <\/div>\n

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Musculoskeletal Issues\n<\/h2>\n <\/div>\n
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Classical phenotype5<\/sup><\/strong><\/p>\n