{"id":598,"date":"2023-05-23T13:38:34","date_gmt":"2023-05-23T13:38:34","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/?page_id=598"},"modified":"2025-12-15T13:31:17","modified_gmt":"2025-12-15T13:31:17","slug":"faq","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/faq\/","title":{"rendered":"FAQ"},"content":{"rendered":"<div id=\"acf-block-691c9f560e795\" class=\"hero hero-roctavian\">\n    <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/Group-8194-e1763483504971.png?v=1.49);\"><\/div>\n    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/HCP_5.3-FAQs_MOBILE.png?v=1.49);\"><\/div>\n    <div class=\"overlay\"><\/div>\n\n    <div class=\"hero-content\">\n        <div class=\"title-area\">\n                            <h1>FREQUENTLY ASKED QUESTIONS\n<\/h1>\n                                <\/div>\t\t\n                    <div class=\"text-area\">\n                <div class=\"text-area-content\">\n                                        <div class=\"text\">\n                        <p>Have questions about ROCTAVIAN that aren\u2019t answered here?<\/p>\n                    <\/div>\n                                                                <div class=\"cta\">\n                                                                                    <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/connect-with-us\/\" target=\"_self\">Connect with Us<\/a><\/p>\n                        <\/div>\n                                    <\/div>\n            <\/div>\n                            <div class=\"image-caption\">\n                <p>Andrew S., dosed with ROCTAVIAN in<br \/>\n2018 as part of a clinical trial.<\/p>\n            <\/div>\n\n            <div class=\"additional-caption\">\n                            <\/div>\n            <\/div>\n<\/div>\n\n\n<div id=\"acf-block-646ced723b62e\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-646ced723b791\" class=\"block-wysiwyg\">\n            <h2>FAQs<\/h2>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-646ced723bc48\" class=\"block accordion block-zero-top\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\" itemscope itemtype=\"https:\/\/schema.org\/FAQPage\" prefix=\"og: https:\/\/ogp.me\/ns#\">\n\t\t                                                                                <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">Why should I choose ROCTAVIAN for patients with severe hemophilia A?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>ROCTAVIAN is a one-time infusion that was studied in the longest and largest Phase 3 gene therapy clinical trial for severe hemophilia A\u2014now with 5 years of data demonstrating:<\/p>\n<ul>\n<li>Years of endogenous Factor VIII production<\/li>\n<li>Improved bleed control for years<\/li>\n<li>Freedom from continuous prophylaxis for years<\/li>\n<li>Now with 5 years of safety profile data<\/li>\n<li>The one-time cost of ROCTAVIAN is covered by most insurance plans. And the team at BioMarin RareConnections\u2122 is here to help navigate the reimbursement process for ROCTAVIAN<\/li>\n<\/ul>\n<p><a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\">Review the 5-year data.<\/a><\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">How do I get my patient started on ROCTAVIAN?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p class=\"p1\">Important first steps to treatment with ROCTAVIAN are:<\/p>\n<ol>\n<li class=\"p1\"><a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/starting-patients\/\"><span class=\"s1\">Test for eligibility <\/span><\/a>with the AAV5 DetectCDx\u2122 blood test to confirm absence of AAV5 antibodies<sup><span class=\"s2\">1<\/span><\/sup><\/li>\n<li class=\"p1\"><a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/connect-with-us\/\">Enroll your patients<\/a> in BioMarin RareConnections\u2122 to allow our team of experts to provide support and expedite access to ROCTAVIAN<\/li>\n<\/ol>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">Where can my patient receive ROCTAVIAN?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>ROCTAVIAN is administered at hemophilia treatment centers (HTCs) throughout the United States. These centers are not only familiar with the logistics of the infusion and follow-up monitoring, but also the coverage process.<\/p>\n<p>You can help patients connect with a hemophilia treatment center using our <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/find-a-hemophilia-treatment-center\/\">HTC Finder Tool<\/a>.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">What if my patient doesn\u2019t live near a hemophilia treatment center?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>We may be able to help! While there are a number of <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/find-a-hemophilia-treatment-center\/\">HTCs prescribing ROCTAVIAN<\/a> throughout the United States, travel-related logistics may be a concern. <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/connect-with-us\/\">Enroll your patients<\/a> in BioMarin RareConnections\u2122 to allow our team of experts to provide support and expedite access to ROCTAVIAN.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">Is my patient eligible for ROCTAVIAN?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>ROCTAVIAN is approved for adults with severe hemophilia A who do not have antibodies to the AAV5 virus, which is determined by a blood test. Learn more about <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/starting-patients\/\">how to test for eligibility for ROCTAVIAN<\/a>.<sup>1<\/sup><\/p>\n<p><small>AAV5 DetectCDx\u2122 is a trademark of ARUP Laboratories.<\/small><\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">What if my patient is eligible but hesitant to move forward?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>The decision to make a change in treatment can be an emotional one, but our team of experts at <a href=\"https:\/\/www.biomarin-rareconnections.com\/hcp\/roctavian\/biomarin-rareconnections-support-services\/\" target=\"_blank\" rel=\"noopener\">BioMarin RareConnections\u2122<\/a> is here to provide support to you and your patients every step of the way. Once patients enroll, they can get questions about ROCTAVIAN answered, receive one-to-one educational and product support, and learn about the experiences of other <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/patient-stories\/\">patients who chose ROCTAVIAN<\/a>.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">How much does gene therapy with ROCTAVIAN cost?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>The one-time cost of ROCTAVIAN is covered by most insurance plans. If you have questions about costs or coverage, we can help. Our team of experts at <a href=\"https:\/\/www.biomarin-rareconnections.com\/hcp\/roctavian\/biomarin-rareconnections-support-services\/\" target=\"_blank\" rel=\"noopener\">BioMarin RareConnections\u2122<\/a>\u00a0is here to provide support and expedite access to ROCTAVIAN.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">How can I determine if ROCTAVIAN is covered for my patient?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>If you have questions about coverage or billing concerns for ROCTAVIAN, we can help. <a href=\"https:\/\/www.biomarin-rareconnections.com\/roctavian\/enroll-in-biomarin-rareconnections\/\" target=\"_blank\" rel=\"noopener\">Enroll your patients<\/a> in BioMarin RareConnections\u2122 to allow our team of experts to provide support and expedite access to ROCTAVIAN.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">Are there long-term data with ROCTAVIAN?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>BioMarin began clinical trials of ROCTAVIAN in 2015,* making it the most extensively studied hemophilia A gene therapy. An ongoing, prospective, Phase 3, open-label, single-dose, single-arm, multinational study began in 2017 (N=134), and data continue to be collected.<sup><span class=\"s1\">1,3,4<\/span><\/sup><a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\"><span class=\"s1\"> Review the 5-year data.<\/span><\/a><\/p>\n<p><small>*The first patient received ROCTAVIAN in a Phase 1\/2 clinical trial.<sup>3<\/sup><\/small><\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">Can ROCTAVIAN help my patients maintain Factor VIII activity levels?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>ROCTAVIAN has been proven to deliver <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\">Factor VIII activity levels for 5 years for most patients<\/a>. In the clinical trial, some patients had increased Factor VIII levels, but it was determined that they had not responded or lost response to ROCTAVIAN.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">What are the most common adverse reactions\/side effects experienced with ROCTAVIAN?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>The most common adverse reactions (\u22655%) to ROCTAVIAN were nausea, fatigue, headache, vomiting, abdominal pain, and infusion-related reactions.<sup>1<\/sup><\/p>\n<p>The <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/safety\/\">safety profile of ROCTAVIAN<\/a> was evaluated in 134 patients in the Phase 3 study (112 rollover and 22 directly enrolled). Long-term safety continues to be evaluated in the long term follow-up study. <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/safety\/\">Learn more about the safety of ROCTAVIAN<\/a>.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">What happens if ROCTAVIAN doesn\u2019t work?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>Administration of ROCTAVIAN does not eliminate the ability to return to prophylaxis. In the clinical trial, some patients had increased Factor VIII levels, but it was determined that they had not responded or lost response to ROCTAVIAN. These patients returned to prophylaxis.<sup>1<\/sup><\/p>\n<p>Take a closer look at the <a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\">clinical trial data for ROCTAVIAN.<\/a><\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">What kind of support does BioMarin offer?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p>If you have questions or concerns about data, coverage, and billing for ROCTAVIAN, or want to connect a patient with an HTC, we can help. <a href=\"https:\/\/www.biomarin-rareconnections.com\/roctavian\/enroll-in-biomarin-rareconnections\/\" target=\"_blank\" rel=\"noopener\">Enroll your patients<\/a> in BioMarin RareConnections\u2122 to allow our team of experts to provide support and expedite access to ROCTAVIAN.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                                                                            <div class=\"accordion-item\" itemprop=\"mainEntity\" itemscope itemtype=\"http:\/\/schema.org\/Question\">\n                        <div class=\"accordion-title\">\n                            <div class=\"accordion-trigger\">\n                                <span><\/span>\n                                <span><\/span>\n                            <\/div>\n                            <h2 itemprop=\"name\">Curious about the experiences of patients who have received ROCTAVIAN?\n<\/h2>\n                        <\/div>\n                        <div class=\"accordion-content\" itemprop=\"acceptedAnswer\" itemscope itemtype=\"http:\/\/schema.org\/Answer\">\n                            <div itemprop=\"text\">                                <p><a href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/patient-stories\/\">Hear firsthand experiences<\/a> from people who chose to move forward with single-infusion ROCTAVIAN.<\/p>\n                            <\/div>                        <\/div>\n                    <\/div>\n                            \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-691ca214a0795\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-691ca214a08d0\" class=\"block-wysiwyg\">\n            <p><small><strong>References: <\/strong><br \/>\n<strong>1.<\/strong> ROCTAVIAN\u00ae (valoctocogene roxaparvovec-rvox). Prescribing information. BioMarin International, Ltd.; 2023. <strong>2.<\/strong> Klamroth R, Hayes G, Andreeva T, et al. Global seroprevalence of pre-existing immunity against AAV5 and other AAV serotypes in people with hemophilia A. Hum Gene Ther. 2022;33(7-8):432-441. doi:10.1089\/ hum.2021.287<\/small><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-646ced723d571\" class=\"block call-to-action dark-cta\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\" style=\"\">\n\t\t\t\t<div class=\"overlay\"><\/div>\n\t\t\t\t<div class=\"cta-content\">\n\t\t\t\t                            <div class=\"cta-image\">\n                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2023\/05\/5.2_FAQs-icon-750x750.png\" alt=\"Two speech bubbles in a circle; one has a question mark in it. The other contains an ellipses\" \/>                        <\/div>\n                    \t\t\t\t\t<div class=\"cta-content-main\">\n                        <div class=\"content-block\">\n\t\t\t\t\t        \t\t\t\t\t        \t\t\t\t\t\t        <h2 class=\"h3\">Have additional questions about ROCTAVIAN?\n<\/h2>\n\t\t\t\t\t\t    \t\t\t\t\t\t    \t\t\t\t\t\t        <p>Connect with our team of experts for more information.<\/p>\n\t\t\t\t\t\t    \t\t\t\t\t    <\/div>\n\t\t\t\t\t                                <div class=\"content-block\">\n                                <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/connect-with-us\/\" target=\"_self\">CONNECT WITH US<\/a><\/p>\n                            <\/div>\n\t\t\t\t\t                        <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-598","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Frequently Asked Questions| ROCTAVIAN\u00ae (valoctocogene roxaparvovec-rvox) for Healthcare Professionals<\/title>\n<meta name=\"description\" content=\"Answers to some of the most frequently asked questions about ROCTAVIAN\u00ae (valoctocogene roxaparvovec-rvox), the only one-time gene therapy for the treatment of severe hemophilia A\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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ROCTAVIAN\u2122 (valoctocogene roxaparvovec-rvox) for Healthcare Professionals\" \/>\n<meta name=\"twitter:description\" content=\"Answers to some of the most frequently asked questions about ROCTAVIAN\u2122 (valoctocogene roxaparvovec-rvox), the only one-time gene therapy for the treatment of severe hemophilia A\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/roctavian\\\/faq\\\/\",\"url\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/roctavian\\\/faq\\\/\",\"name\":\"Frequently Asked Questions| ROCTAVIAN\u00ae (valoctocogene roxaparvovec-rvox) for Healthcare Professionals\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/roctavian\\\/#website\"},\"datePublished\":\"2023-05-23T13:38:34+00:00\",\"dateModified\":\"2025-12-15T13:31:17+00:00\",\"description\":\"Answers to some of the most frequently asked questions 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