{"id":5,"date":"2023-05-22T11:33:29","date_gmt":"2023-05-22T11:33:29","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/?page_id=5"},"modified":"2025-12-15T13:08:00","modified_gmt":"2025-12-15T13:08:00","slug":"home","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/","title":{"rendered":"Home"},"content":{"rendered":"<div id=\"acf-block-690b708cbec4d\" class=\"hero hero-no-overlay pull-bottom\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/Group-820611-2000x800.png);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/Group-8201.png?v=1.49);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t    <span class=\"section-title\">    <\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <h1>&nbsp;\n&nbsp;\n&nbsp;\n&nbsp;\n&nbsp;\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                    \t\t\t\t        <a class=\"button button-arrow\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\" target=\"_self\">SEE THE DATA<\/a>\t\t\t\t                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-68f8ec03b927e\" class=\"block cards cards-3-col\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-68f8ec03b9942\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/Phase-3-data.png?v=1.49\" alt=\"\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Demonstrated efficacy with 5 years of Phase 3 data<sup>2<\/sup>\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\" target=\"_self\">SEE THE DATA<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-68f8ec03b99d2\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/Patient-icon.png?v=1.49\" alt=\"\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>Discover why patients have chosen ROCTAVIAN\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/patient-stories\/\" target=\"_self\">WATCH THEIR STORIES<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-68f8ec03b9a50\" class=\"card card-fixed-button\" data-muted-autoplay=\"false\">\n    \t    \n\n                    <img decoding=\"async\" class=\"card-image\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/11\/Group-8182.svg\" alt=\"\" \/>        \n\t    <div class=\"card-content\">\n                            <h4>How do you start patients on ROCTAVIAN?\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/referring-patients\/\" target=\"_self\">CHECK FOR ELIGIBILITY<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6908ba0e8bfc0\" class=\"block single-stacked-video\" data-muted-autoplay=\"false\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            \n                            <h2 class=\"h3\">\u201cI never imagined a day where I wouldn\u2019t have to actively treat with factor.\u201d\n<\/h2>\n                                        <div class=\"supporting-text\">\n                    <h6>\u2014Andrew W., dosed with ROCTAVIAN in a clinical trial in 2018<\/h6>\n                <\/div>\n                        \n            <div class=\"video-poster\">\n                <a class=\"modal-video permitted\" href=\"#\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/10\/00_Andrew_w.png?v=1.49);\">Play<\/a>\n            <\/div>\n            \n                            <p><a class=\"button\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/patient-stories\/\" target=\"_self\">Watch his story<\/a><\/p>            \n                    <\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-68f8ec03b9feb\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-68f8ec03ba138\" class=\"block-wysiwyg\">\n            <h2>The one-time cost of ROCTAVIAN is covered by most insurance plans<\/h2>\n<ul>\n<li>To date, payers have published policies covering ROCTAVIAN for more than <strong>250 million commercial and government insured patients<\/strong><\/li>\n<li>BioMarin RareConnections<sup>TM<\/sup> is here to help navigate the reimbursement process for ROCTAVIAN<\/li>\n<\/ul>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-68f8ec03ba412\" class=\"block call-to-action call-to-action-no-overlay light-cta\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\" style=\"\">\n\t\t\t\t<div class=\"overlay\"><\/div>\n\t\t\t\t<div class=\"cta-content\">\n\t\t\t\t                            <div class=\"cta-image\">\n                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/10\/RareConnections_Logo_FINAL_TM_RGB.svg\" alt=\"BioMarin Rare Connections logo\" \/>                        <\/div>\n                    \t\t\t\t\t<div class=\"cta-content-main\">\n                        <div class=\"content-block\">\n\t\t\t\t\t        \t\t\t\t\t        \t\t\t\t\t\t        <h2 class=\"h3\">Expedite access by enrolling patients<br \/>\nin BioMarin RareConnections\n<\/h2>\n\t\t\t\t\t\t    \t\t\t\t\t\t    \t\t\t\t\t\t        <p>Enrolling connects you and your patients to our team for education and product support.<\/p>\n\t\t\t\t\t\t    \t\t\t\t\t    <\/div>\n\t\t\t\t\t                                <div class=\"content-block\">\n                                <p><a class=\"button button-ghost\" href=\"#\" target=\"_self\">ENROLL NOW<\/a><\/p>\n                            <\/div>\n\t\t\t\t\t                        <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6908bc4a84866\" class=\"block wrapped-content block-zero-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<figure id=\"acf-block-6908bb4ce3fab\">\n    <div class=\"image image-rounded image-natural-size image-align-center\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2025\/10\/3.0-REFERING_question-icon-e1762179972404.png?v=1.49\" alt=\"Two speech bubbles interacting in conversation\" \/>            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-6908bc4a8488d\" class=\"block-wysiwyg\">\n            <h1 style=\"text-align: center\">Connect with us<\/h1>\n<p style=\"text-align: center\">Interested in receiving more information, or ready to connect with a BioMarin representative about ROCTAVIAN?<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-64708a04467e7\" class=\"block hcp-sign-up-form block-zero-top\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                                        <p>All fields marked with an * are required.<\/p>\n            \n            <div class=\"block form-box\">\n                <p>*Required fields<\/p>\n                <form id=\"hcp-sign-up\" name=\"Stay up to date\">\n                    <div class=\"form-columns\">\n                        <div class=\"form-item\">\n                            <label for=\"first-name\">First name<span class=\"required\">*<\/span><\/label>\n                            <input class=\"text\" id=\"first-name\" type=\"text\" required\n                            data-pristine-required-message=\"Please enter your first name\">\n                        <\/div>\n\n                        <div class=\"form-item\">\n                            <label for=\"last-name\">Last name<span class=\"required\">*<\/span><\/label>\n                            <input class=\"text\" id=\"last-name\" type=\"text\" required\n                            data-pristine-required-message=\"Please enter your last name\">\n                        <\/div>\n                    <\/div>\n                    \n                    <div class=\"form-columns\">\n                        <div class=\"form-item\">\n                            <label for=\"email\">Email<span class=\"required\">*<\/span><\/label>\n                            <input class=\"text\" id=\"email\" type=\"email\" required\n                            data-pristine-required-message=\"Please enter your email address\">\n                        <\/div>\n\n                        <div class=\"form-item\">\n                            <label for=\"phone-number\">Phone<\/label>\n                            <input class=\"text\" id=\"phone-number\" type=\"text\"\n                            data-pristine-required-message=\"Please enter your phone number\"\n                            data-pristine-pattern-message=\"Please enter a valid phone number\"\n                            data-pristine-pattern=\"\/^\\(?([0-9]{3})\\)?[-. ]?([0-9]{3})[-. ]?([0-9]{4})$\/\">\n                        <\/div>\n                    <\/div>\n                    \n                    <div class=\"form-columns\">\n                        <div class=\"form-item\">\n                            <label for=\"zip-code\">US postal code<span class=\"required\">*<\/span><\/label>\n                            <input class=\"text\" id=\"zip-code\" type=\"text\" required\n                            data-pristine-required-message=\"Please enter your ZIP code\"\n                            data-pristine-pattern-message=\"Please enter a valid ZIP code\"\n                            data-pristine-pattern=\"\/^\\d{5}(-\\d{4})?$\/i\">\n                        <\/div>\n                        \n                        <div class=\"form-item\">\n                            <label for=\"medical-speciality\">Specialty<span class=\"required\">*<\/span><\/label>\n                            <select class=\"text\" id=\"medical-speciality\" required\n                            data-pristine-required-message=\"Please select your specialty\">\n                                <option value=\"\">Select your specialty<\/option>\n                                <option value=\"Audiology\">Audiology<\/option>\n                                <option value=\"Behavioral Neurology &amp; Neuropsychiatry\">Behavioral Neurology &amp; Neuropsychiatry<\/option>\n                                <option value=\"Cardiology\">Cardiology<\/option>\n                                <option value=\"Clinical Biochemical Genetics\">Clinical Biochemical Genetics<\/option>\n                                <option value=\"Diagnostic Radiology\">Diagnostic Radiology<\/option>\n                                <option value=\"Electroencephalography\">Electroencephalography<\/option>\n                                <option value=\"Endocrinology, Diabetes &amp; Metabolism\">Endocrinology, Diabetes &amp; Metabolism<\/option>\n                                <option value=\"ENT\/Otorhinolaryngologist\">ENT\/Otorhinolaryngologist<\/option>\n                                <option value=\"Gastroenterology\">Gastroenterology<\/option>\n                                <option value=\"General Practice\/Family\">General Practice\/Family<\/option>\n                                <option value=\"Genetics\">Genetics<\/option>\n                                <option value=\"Hearing and Speech\">Hearing and Speech<\/option>\n                                <option value=\"Internal Medicine\">Internal Medicine<\/option>\n                                <option value=\"Neonatology\">Neonatology<\/option>\n                                <option value=\"Neurology\">Neurology<\/option>\n                                <option value=\"Nutrition, Metabolic\">Nutrition, Metabolic<\/option>\n                                <option value=\"Obstetrics\">Obstetrics<\/option>\n                                <option value=\"Orthopedics\">Orthopedics<\/option>\n                                <option value=\"Pediatric Endocrinology\">Pediatric Endocrinology<\/option>\n                                <option value=\"Pediatric Endocrinology, Diabetes &amp; Metabolism\">Pediatric Endocrinology, Diabetes &amp; Metabolism<\/option>\n                                <option value=\"Pediatric ENT\">Pediatric ENT<\/option>\n                                <option value=\"Pediatric Gastroenterology\">Pediatric Gastroenterology<\/option>\n                                <option value=\"Pediatric Gastroenterology &amp; Metabolism\">Pediatric Gastroenterology &amp; Metabolism<\/option>\n                                <option value=\"Pediatric Genetics\">Pediatric Genetics<\/option>\n                                <option value=\"Pediatric Metabolism\">Pediatric Metabolism<\/option>\n                                <option value=\"Pediatric Neurology\">Pediatric Neurology<\/option>\n                                <option value=\"Pediatric Neurosurgery\">Pediatric Neurosurgery<\/option>\n                                <option value=\"Pediatric Orthopedics\">Pediatric Orthopedics<\/option>\n                                <option value=\"Pediatric Radiology\">Pediatric Radiology<\/option>\n                                <option value=\"Pediatrics\">Pediatrics<\/option>\n                                <option value=\"Primary Care\">Primary Care<\/option>\n                                <option value=\"Psychology \/ Psychiatry\">Psychology \/ Psychiatry<\/option>\n                                <option value=\"Pulmonology\">Pulmonology<\/option>\n                                <option value=\"Radiology (MRI imaging)\">Radiology (MRI imaging)<\/option>\n                                <option value=\"Research\">Research<\/option>\n                                <option value=\"Social Worker\">Social Worker<\/option>\n                                <option value=\"Surgery\">Surgery<\/option>\n                            <\/select>\n                        <\/div>                                                                     \n                    <\/div>       \n                    \n                    <div class=\"form-columns\">\n                        <div class=\"form-item\">\n                            <label for=\"hospital-clinic-affiliation\">Practice name<span class=\"required\">*<\/span><\/label>\n                            <input class=\"text\" id=\"hospital-clinic-affiliation\" type=\"text\" required\n                            data-pristine-required-message=\"Please enter your practice name\">\n                        <\/div> \n                        \n                        <div class=\"form-item\">\n                            <label for=\"professional-designation\">Professional designation<span class=\"required\">*<\/span><\/label>\n                            <select class=\"text\" id=\"professional-designation\" required\n                            data-pristine-required-message=\"Please select your professional designation\">\n                                <option value=\"\">Select your professional designation<\/option>\n                                <option value=\"DO\">DO<\/option>\n                                <option value=\"MA\">MA<\/option>\n                                <option value=\"MD\">MD<\/option>\n                                <option value=\"NP\">NP<\/option>\n                                <option value=\"PA\">PA<\/option>\n                                <option value=\"Pharmacist\">Pharmacist<\/option>\n                                <option value=\"PhD\">PhD<\/option>\n                                <option value=\"RN\">RN<\/option>\n                                <option value=\"Other\">Other<\/option>\n                            <\/select>\n                        <\/div>  \n                    <\/div>                                                                                                                          \n\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"rep-contact-me\" name=\"rep_contact_me\">\n                        <label for=\"rep-contact-me\">I would like to be connected with a local BioMarin representative to learn more about local events and information about ROCTAVIAN.<\/small><\/label>\n                    <\/div>\n\n                    <div class=\"form-item check-item\">\n                        <input type=\"checkbox\" id=\"accept-ts-cs\" name=\"accept_ts_cs\" required\n                        data-pristine-required-message=\"Please agree to the terms of use\">\n                        <label for=\"accept-ts-cs\"><strong>I agree to the Terms of Use.<\/strong><span class=\"required\">*<\/span><br>By checking this box and clicking &ldquo;Submit&rdquo; below, I confirm I am at least 18 years old; confirm I agree to BioMarin\u2019s <a href=\"https:\/\/www.biomarin.com\/data-privacy-center\/\" target=\"_blank\">Privacy Policy and CCPA Notice<\/a> and <a href=\"https:\/\/www.biomarin.com\/terms-of-use\/en-us\/\" target=\"_blank\">Terms of Use<\/a>; consent to BioMarin, its successors, agents, and\/or assignees using the email address and\/or phone number I have provided to contact me with information about ROCTAVIAN and hemophilia and keep me informed about news and developments, market research or surveys, or other opportunities that may be of interest to me; and confirm I understand these communications\/materials may contain information that markets or advertises BioMarin products, goods, or services.<\/label>\n                    <\/div>\n\n                    <div class=\"form-item\">\n                        <input type=\"submit\" class=\"button\" value=\"Submit\">\n                    <\/div>\n                <\/form>\n                <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n            <\/div>\n\n            <div class=\"block form-success-confirmation\" style=\"display:none;\">\n                                    <h2>Thank you for registering. We&#8217;ll be in touch soon.<\/h2>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6744581047bfe\" class=\"block wrapped-content bg-band bg-band-white block-tight-bottom block-remove-top-padding\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-6744581047c23\" class=\"block-wysiwyg\">\n            <p><strong>References:<br \/>\n<\/strong>1. ROCTAVIAN\u00ae (valoctocogene roxaparvovec-rvox) Prescribing information. BioMarin International, Ltd.; 2023. 2. Data on file. BioMarin Pharmaceutical Inc.; 2025.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-68f8ec03ba7c3\" class=\"block call-to-action call-to-action-no-overlay dark-cta\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\" style=\"\">\n\t\t\t\t<div class=\"overlay\"><\/div>\n\t\t\t\t<div class=\"cta-content\">\n\t\t\t\t                            <div class=\"cta-image\">\n                            <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/wp-content\/uploads\/sites\/3\/2023\/05\/5.2_FAQs-icon-750x750.png\" alt=\"Two speech bubbles in a circle; one has a question mark in it. The other contains an ellipses\" \/>                        <\/div>\n                    \t\t\t\t\t<div class=\"cta-content-main\">\n                        <div class=\"content-block\">\n\t\t\t\t\t        \t\t\t\t\t        \t\t\t\t\t\t        <h2 class=\"h3\">Are your patients ready for potential freedom from continuous prophylaxis for years?\n<\/h2>\n\t\t\t\t\t\t    \t\t\t\t\t\t    \t\t\t\t\t\t        <p>Explore the 5-year data now.<\/p>\n\t\t\t\t\t\t    \t\t\t\t\t    <\/div>\n\t\t\t\t\t                                <div class=\"content-block\">\n                                <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/hcp.biomarin.com\/en-us\/roctavian\/efficacy\/\" target=\"_self\">SEE THE DATA<\/a><\/p>\n                            <\/div>\n\t\t\t\t\t                        <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene therapy for severe hemophilia A | ROCTAVIAN\u00ae (valoctocogene roxaparvovec-rvox) for Healthcare Professionals<\/title>\n<meta name=\"description\" content=\"ROCTAVIAN\u00ae is the only gene therapy treatment option for adults with severe hemophilia A without active factor VIII inhibitors\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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