{"id":565,"date":"2023-01-12T03:48:05","date_gmt":"2023-01-12T03:48:05","guid":{"rendered":"https:\/\/pkudsehcp-dev-001.azurewebsites.net\/en-us\/phenylketonuria\/?page_id=565"},"modified":"2024-06-13T13:53:57","modified_gmt":"2024-06-13T13:53:57","slug":"talking-to-your-patients","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/pku\/talking-to-your-patients\/","title":{"rendered":"Managing PKU"},"content":{"rendered":"
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Discussion topics to consider with your patients with PKU\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n

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Patients may experience
\nsymptoms of high blood Phe levels without even knowing it1,2<\/sup><\/h3>\n

Consider asking your patients<\/span><\/strong> about their experiences living with and managing PKU, such as details about work, school, and social relationships<\/p>\n <\/div>\n<\/div>\n\n

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Rates of anxiety disorders and depression are higher in the PKU population compared with the general population3-5<\/sup><\/h3>\n

Consider asking your patients<\/span><\/strong> if there are situations where they are struggling with work, school, or personal relationships<\/p>\n <\/div>\n<\/div>\n\n

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Impairments in executive function have been correlated with challenges in communication skills and social relationships3<\/sup><\/h3>\n

Consider asking your patients<\/span><\/strong> if they are
\nexperiencing feelings of social isolation<\/p>\n <\/div>\n<\/div>\n\n

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PKU management can be difficult for many patients<\/h3>\n

Consider asking your patients<\/span><\/strong> about their top 2 to 3 issues that they struggle with<\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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Many adults with PKU have elevated blood Phe levels on existing management2<\/sup><\/h2>\n

Could your patients be struggling to control their Phe?<\/p>\n <\/div>\n \n

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A survey of 44 clinics covering more than 3000  
\npatients with PKU found that of adults \u226518 years of age:<\/h3>\n <\/div>\n\n
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Learn more about PKU<\/h2>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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Getting patients to return to clinic is essential\n<\/h2>\n\t\t\t\t\t\t \t\t\t\t\t\t \t\t\t\t\t <\/div>\n\t\t\t\t\t
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Go to Helpful Tips<\/a><\/p>\n <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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References: 1.<\/strong> Vockley J, Andersson HC, Antshel KM, et al. American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guidelines. Genet Med<\/em>. 2014;16(2):188-200. 2.<\/strong> Jurecki ER, Cederbaum S, Kopesky J, et al. Adherence to clinic recommendations among patients with phenylketonuria in the United States. Mol Genet Metab. 2017;120(3):190-197. 3.<\/strong> Ashe K, Kelso W, Farrand S, et al. Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. Front Psychiatry<\/em>. 2019;10:561. doi:10.3389\/fpsyt.2019.00561. 4.<\/strong> Bilder DA, Noel JK, Baker ER, et al. Systematic review and meta-analysis of neuropsychiatric symptoms and executive functioning in adults with phenylketonuria. Dev Neuropsychol<\/em>. 2016;41(4):245-260. 5.<\/strong> Bilder DA, Kobori JA, Cohen-Pfeffer JL, Johnson EM, Jurecki ER, Grant ML. Neuropsychiatric comorbidities in adults with phenylketonuria: a retrospective cohort study. Mol Genet Metab<\/em>. 2017;12(1):1-8.<\/small><\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-565","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPatient impact of PKU symptoms l Managing PKU<\/title>\n<meta name=\"description\" content=\"Managing PKU can be challenging for your patients and their caregivers. 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