{"id":7162,"date":"2025-06-12T11:09:30","date_gmt":"2025-06-12T11:09:30","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/?page_id=7162"},"modified":"2025-11-17T19:18:12","modified_gmt":"2025-11-17T19:18:12","slug":"mechanism-of-action","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/mechanism-of-action\/","title":{"rendered":"How it works"},"content":{"rendered":"
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ONLY PALYNZIQ DIRECTLY SUBSTITUTES FOR THE PAH ENZYME1<\/sup><\/span>\n<\/h1>\n <\/div>\n\n
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PALYNZIQ®<\/sup> (pegvaliase-pqpz) Injection is an enzyme replacement therapy designed to work in all types of PKU, regardless of BH4 responsiveness or residual PAH activity.1<\/sup><\/p>\n \"\" \"\" <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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See how PALYNZIQ is taken<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Reference:<\/strong> 1.<\/strong> Adams D, Andersson HC, Bausell H, et al. Use of pegvaliase in the management of phenylketonuria: case series of early experience in US clinics. Mol Gen Metab Rep<\/em>. 2021;28:100790. doi:10.1016\/j.ymgmr.2021.100790<\/small><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-7162","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nBioMarin | How PALYNZIQ\u00ae Works<\/title>\n<meta name=\"description\" content=\"Explore the Mechanism of Action & see how it works for your patients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/mechanism-of-action\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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