{"id":7162,"date":"2025-06-12T11:09:30","date_gmt":"2025-06-12T11:09:30","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/?page_id=7162"},"modified":"2026-04-15T10:56:42","modified_gmt":"2026-04-15T10:56:42","slug":"mechanism-of-action","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/mechanism-of-action\/","title":{"rendered":"How it works"},"content":{"rendered":"
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THE ONLY THERAPY
\nTHAT DOES NOT RELY
\nON THE PAH ENZYME1-3<\/sup><\/span>\n<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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PALYNZIQ\u00ae<\/sup> (pegvaliase-pqpz) Injection directly substitutes for the missing PAH enzyme to metabolize blood Phe\u2014without relying on BH4 responsiveness or residual PAH activity1<\/sup><\/h2><\/p>\n <\/div>\n\n
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\n\t\t\t \"Molecular\t\t\t<\/div>\n\t\t\t
\n\t\t\t \"Molecular\t\t\t<\/div>\n <\/div>\n <\/figure>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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Patients taking PALYNZIQ achieved substantial Phe reduction.<\/h3>\n

Explore the data<\/a><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n

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BH4, tetrahydrobiopterin; PAH, phenylalanine hydroxylase enzyme.<\/small><\/p>\n

 <\/p>\n

References:<\/strong> 1.<\/strong> Adams D, Andersson HC, Bausell H, et al. Use of pegvaliase in the management of phenylketonuria: case series of early experience in US clinics. Mol Gen Metab Rep<\/em>. 2021;28:100790. doi:10.1016\/j.ymgmr.2021.100790 2.<\/strong> SEPHIENCE Package insert. PTC Therapeutics, Inc; 2025. 3.<\/strong> Elsharkawi I. Phenylketonuria (PKU). Medscape. Updated August 18, 2025. Accessed November 17, 2025. https:\/\/emedicine.medscape.com\/article\/947781<\/small><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-7162","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nHow PALYNZIQ\u00ae Works | Mechanism of Action<\/title>\n<meta name=\"description\" content=\"Learn how PALYNZIQ\u00ae substitutes for the missing PAH enzyme to reduce phenylalaninelevels.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/mechanism-of-action\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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