{"id":7078,"date":"2025-06-12T08:58:38","date_gmt":"2025-06-12T08:58:38","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/?page_id=7078"},"modified":"2026-04-15T10:42:01","modified_gmt":"2026-04-15T10:42:01","slug":"pku-management","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/pku-management\/","title":{"rendered":"Challenges in PKU"},"content":{"rendered":"
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BH4 THERAPIES AND
\nRESTRICTED DIETS
\nMAY NOT BE THE RIGHT CHOICE FOR MANY PEOPLE WITH PKU1-4<\/sup><\/span>\n<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n\n
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Restricted diets are challenging1,2<\/sup>\n<\/p>\n <\/div>\n

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BH4 therapies are not always an option3,4<\/sup>\n<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n

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PKU management that requires a restricted diet is often ineffective1,2<\/sup>\n<\/h2>\n \n \n \n
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Dietary adherence becomes especially challenging as children reach adolescence and face:\n<\/h2>\n \n \n \n
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When dietary adherence is lost early, it can be hard to regain later10,11<\/sup>\n<\/h2>\n \n \n \n
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PKU management decisions made during adolescence can set the tone for long-term Phe control.6,10,14<\/sup><\/span><\/h3>\n <\/div>\n <\/div>\n \n
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BH4 therapies are not an option for some people with classical PKU3,4<\/sup>\n<\/h2>\n \n \n \n
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