{"id":7078,"date":"2025-06-12T08:58:38","date_gmt":"2025-06-12T08:58:38","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/?page_id=7078"},"modified":"2025-11-17T19:09:52","modified_gmt":"2025-11-17T19:09:52","slug":"pku-management","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/pku-management\/","title":{"rendered":"Challenges in PKU"},"content":{"rendered":"
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BH4 THERAPIES AND
\nPHE-RESTRICTED DIETS
\nMAY NOT BE THE RIGHT CHOICE FOR MANY ADULTS WITH PKU1,2<\/sup><\/span>\n<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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PKU management that requires a Phe-restricted diet is often ineffective1<\/sup><\/h2>\n <\/div>\n\n
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Lack of access<\/strong> to or affordability of medical foods\/formula and low-protein foods1<\/sup><\/p>\n <\/div>\n <\/div>\n

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Lack of caregiver support<\/strong>, especially as patients transition from adolescence to independent adulthood1<\/sup><\/p>\n <\/div>\n <\/div>\n

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Time<\/strong> it takes to plan and prepare Phe-restricted meals1<\/sup><\/p>\n <\/div>\n <\/div>\n

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Social impact<\/strong> of a Phe-restricted diet, including challenges with socialization and feelings of isolation1<\/sup><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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BH4 therapies are not an option for some adults with classical PKU1,2<\/sup><\/h2>\n <\/div>\n\n
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FDA-approved BH4 therapies vary in effectiveness based on continual adherence to a Phe-restricted diet.2<\/sup><\/p>\n <\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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Challenges will continue to exist for therapies or management approaches that require a long-term restricted diet.2<\/sup>\n<\/h2>\n \t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n <\/div>\n <\/div>\n
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Discover a different PKU treatment option<\/a><\/p>\n <\/div>\n<\/div>\n\n

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References: 1.<\/strong> Rocha JC, Ahring KK, Bausell H, et al. Expert consensus on the long-term effectiveness of medical nutrition therapy and its impact on the outcomes of adults with phenylketonuria. Nutrients<\/em>. 2023;15(18):3940. doi:10.3390\/nu15183940 2.<\/strong> Specola N, Chiesa A. Alternative therapies for PKU. J Inborn Errors Metab Screening<\/em>. 2017;5:1-5. doi:10.1177\/2326409816685734 3.<\/strong> Enns GM, Koch R, Brumm V, Blakely E, Suter R, Jurecki E. Suboptimal outcomes in patients with PKU treated early with diet alone: revisiting the evidence. Mol Genet Metab<\/em>. 2010;101(2-3):99-109. doi:10.1016\/j.ymgme.2010.05.017 4.<\/strong> Smith WE, Berry SA, Bloom K, et al. Phenylalanine hydroxylase deficiency diagnosis and management: a 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG). Genet Med.<\/em> 2025;27(1):101289. doi:10.1016\/j.gim.2024.101289 5.<\/strong> Blau N, Hennermann JB, Langenbeck U, Lichter-Konecki U. Diagnosis, classification, and genetics of phenylketonuria and tetrahydrobiopterin (BH4) deficiencies. Mol Genet Metab.<\/em> 2011;104(suppl):S2-S9. doi:10.1016\/j.ymgme.2011.08.017 6.<\/strong> Hillert A, Anikster Y, Belanger-Quintana A, et al. The genetic landscape and epidemiology of phenylketonuria. Am J Hum Genet<\/em>. 2020;107(2):234-250. doi:10.1016\/j.ajhg.2020.06.006<\/small><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-7078","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nBioMarin PALYNZIQ HCP | PKU Patient Challenges<\/title>\n<meta name=\"description\" content=\"Learn About the Issues Patients\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/pku-management\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BioMarin PALYNZIQ HCP | 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