{"id":5,"date":"2022-07-20T18:05:12","date_gmt":"2022-07-20T18:05:12","guid":{"rendered":"https:\/\/palynziqhcp-dev-001.azurewebsites.net\/en-us\/palynziq\/?page_id=5"},"modified":"2024-06-12T13:41:07","modified_gmt":"2024-06-12T13:41:07","slug":"palynziq-for-pku","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/","title":{"rendered":"PALYNZIQ for PKU"},"content":{"rendered":"
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Give your patients the chance for low Phe\n<\/h1>\n

PALYNZIQ\u00ae<\/sup> (pegvaliase-pqpz) Injection gives eligible adult patients the chance to see blood Phe levels below 360 \u03bcmol\/L1<\/sup><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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ACMG recommends maintaining blood Phe levels below\u00a0360 \u03bcmol\/L (6 mg\/dL)\u00a0for patients with PKU2<\/sup><\/p>\n

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PALYNZIQ Clinical Trial Results\n<\/h4>\n \n \n\n

Discover long-term efficacy and safety data out to 3 years<\/p>\n\n\n\n \n <\/div>\n

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See the data<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Dosing and Administration\n<\/h4>\n \n

Personalize your patients’ dosing regimens to help them achieve blood Phe levels \u2264360 \u00b5mol\/L<\/p>\n \n <\/div>\n

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Learn more<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Enroll Your Patients\n<\/h4>\n \n

Access all the necessary forms and resources to get your patients started on PALYNZIQ<\/p>\n \n <\/div>\n

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Get started today<\/a><\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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Substantial blood Phe reduction is possible with PALYNZIQ1<\/sup><\/h2>\n\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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\n \"Fork <\/div>\n <\/figure>\n <\/div>\n
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A Phe-restricted diet* is not required in conjunction with PALYNZIQ. The majority of patients were not on a Phe-restricted diet* prior to and during the\u00a0study.1<\/sup><\/p>\n

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  • 57% (149 of 261) were taking medical food and 16% (41 of 261) were on a Phe-restricted diet at baseline<\/li>\n<\/ul>\n <\/div>\n<\/div>\n\n
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    \n \"Droplet <\/div>\n <\/figure>\n <\/div>\n
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    A cross-sectional analysis showed that 66% (57 of 86) of patients had blood Phe levels \u2264360 \u00b5mol\/L at 24 months, and 50% (43 of 86) of the patients had blood Phe levels \u2264120 \u00b5mol\/L at 24 months.1<\/sup><\/p>\n <\/div>\n<\/div>\n\n

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    The majority of patients (89\/118) achieved blood Phe levels \u2264360 \u00b5mol\/L, with 50% of them achieving this level by 10 months in the study.1,3<\/sup><\/p>\n <\/div>\n<\/div>\n\n

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    Rates of hypersensitivity reactions decreased over time from induction\/titration to maintenance phases, despite increasing dose.1<\/sup><\/p>\n

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    • 10% (29 of 285) of patients experienced a total of 42 anaphylaxis episodes1<\/sup><\/li>\n
    • Most common adverse reactions (at least 20% of patients in either treatment phase) were: injection site reactions, arthralgia, hypersensitivity reactions, headache, generalized skin reactions lasting at least 14 days, nausea, abdominal pain, vomiting, cough, oropharyngeal pain, pruritus, diarrhea, nasal congestion, fatigue, dizziness, and anxiety1<\/sup><\/li>\n<\/ul>\n

      *A Phe-restricted diet is defined as >75% of protein intake from medical food.1<\/sup><\/small><\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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      References:\n<\/h4>\n\t\t\t\t\t\t
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      1. PALYNZIQ [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2020.\n<\/span><\/li>\n
      2. Vockley J, Andersson HC, Antshel KM, et al;<\/em> for the American College of Medical Genetics and Genomics Therapeutic Committee. Phenylalanine hydroxylase deficiency: diagnosis and management guideline. Genet Med.<\/em> 2014;16(2):188\u2013200.\n<\/span><\/li>\n
      3. Data on file. BioMarin Pharmaceutical Inc.\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"acf":[],"yoast_head":"\nHome | Palynziq HCP<\/title>\n<meta name=\"description\" content=\"PALYNZIQ\u00ae (pegvaliase-pqpz) Injection for the treatment of phenylketonuria (PKU). 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