{"id":5,"date":"2022-07-20T18:05:12","date_gmt":"2022-07-20T18:05:12","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/?page_id=5"},"modified":"2026-04-15T10:38:26","modified_gmt":"2026-04-15T10:38:26","slug":"homepage","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/palynziq\/","title":{"rendered":"Homepage"},"content":{"rendered":"
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RESET THE STANDARD FOR PHE CONTROL WITH PALYNZIQ<\/span>\n<\/h1>\n

PALYNZIQ\u00ae<\/sup> (pegvaliase-pqpz) Injection is the first and only FDA-approved therapy that can lower Phe levels in people aged 12 and up, across PKU types and regardless of diet.1-3<\/sup>*<\/p>\n See the data<\/a> <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n

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PALYNZIQ is the first and only enzyme replacement therapy<\/span>
\nfor people with PKU1,4,5<\/sup><\/strong><\/h2>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n\n
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Phe reduction in adolescents and adults1<\/sup>\n<\/h4>\n \n \n <\/div>\n
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See PALYNZIQ efficacy data<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Works independently of PAH status or BH4 activity2<\/sup>\n<\/h4>\n \n \n <\/div>\n
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Explore how PALYNZIQ works<\/a><\/p>\n <\/div>\n<\/div>\n\n

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Get your patients started\n<\/h4>\n \n \n <\/div>\n
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Enroll now<\/a><\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

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*A Phe-restricted diet is not required in conjunction with PALYNZIQ. A Phe-restricted diet is defined as >75% of protein intake from medical food.1<\/sup><\/p>\n

BH4, tetrahydrobiopterin; PAH, phenylalanine hydroxylase enzyme.<\/p>\n

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References: 1.<\/strong> PALYNZIQ package insert. Novato, CA: BioMarin Pharmaceutical Inc; February 2026. 2.<\/strong> Adams D, Andersson HC, Bausell H, et al. Use of pegvaliase in the management of phenylketonuria: case series of early experience in US clinics. Mol Gen Metab Rep<\/em>. 2021;28:100790. doi:10.1016\/j.ymgmr.2021.100790 3.<\/strong> Burton B, Sacharow S, Northrup H, et al. Efficacy and safety of the recommended pegvaliase dosing regimen in adults with phenylketonuria in the phase 3 PRISM studies. Poster presented at: SSIEM Annual Symposium; August 30-September 2, 2022; Freiburg, Germany. 4.<\/strong> SEPHIENCE. Package insert. PTC Therapeutics, Inc; 2025. 5.<\/strong> KUVAN package insert. Novato, CA: BioMarin Pharmaceutical Inc; 2024.<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPALYNZIQ\u00ae (pegvaliase-pqpz) Injection | Enzyme Replacement Therapy for PKU<\/title>\n<meta name=\"description\" content=\"Explore PALYNZIQ\u00ae for your patients aged 12 and up with PKU. 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