{"id":87,"date":"2022-09-26T19:29:33","date_gmt":"2022-09-26T19:29:33","guid":{"rendered":"https:\/\/naglazymehcp-dev-001.azurewebsites.net\/en-us\/naglazyme\/?page_id=87"},"modified":"2023-05-25T15:02:29","modified_gmt":"2023-05-25T15:02:29","slug":"mps-vi-management","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/naglazyme\/mps-vi-management\/","title":{"rendered":"MPS VI Management"},"content":{"rendered":"<div id=\"acf-block-64187cde1aa8b\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-64187cde1ace4\" class=\"block-wysiwyg\">\n            <h1>MPS VI Disease Management with NAGLAZYME<sup>\u00ae<\/sup> (galsulfase)<\/h1>\n<h2>NAGLAZYME<sup>\u00ae<\/sup> (galsulfase) is an effective component of integrated care for patients with MPS VI<sup>2,3<\/sup><\/h2>\n<p>NAGLAZYME is the first therapy indicated for long-term treatment in patients with MPS VI.<sup>2,3<\/sup><\/p>\n<p>NAGLAZYME enzyme replacement therapy (ERT) targets the underlying MPS VI disease process by directly replacing the arylsulfatase B (ASB) enzyme with a synthesized and purified version produced using recombinant DNA technology.<sup>3<\/sup><\/p>\n<p>MPS VI experts generally recommend a combined management approach that includes<sup>1<\/sup>:<\/p>\n<ul>\n<li>Interventions to address specific symptoms or conditions (such as surgery for affected joints or heart problems, antibiotic therapy for respiratory infections, or supportive therapies to ease pain and limitation)<sup>1<\/sup><\/li>\n<li>NAGLAZYME ERT to target the underlying MPS VI disease process<sup>1,4<\/sup><\/li>\n<\/ul>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-64187cde1ad21\" class=\"block call-to-action\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"box\" style=\"\">\n\t\t\t\t<div class=\"overlay\"><\/div>\n\t\t\t\t<div class=\"cta-content\">\n\t\t\t\t    \t\t\t\t\t<div class=\"cta-content-main\">\n                        <div class=\"content-block\">\n\t\t\t\t\t        \t\t\t\t\t        \t\t\t\t\t\t        <h2 class=\"h3\">MPS VI often requires the care of multiple specialists due to its multisystemic nature.<sup>1<\/sup>\n<\/h2>\n\t\t\t\t\t\t    \t\t\t\t\t\t    \t\t\t\t\t\t        <p>Learn the latest in symptom-based care for MPS VI, with recommended assessments and treatments by organ system, information on the disease, its biochemical basis, and diagnosis and management.<\/p>\n\t\t\t\t\t\t    \t\t\t\t\t    <\/div>\n\t\t\t\t\t                                <div class=\"content-block\">\n                                <p><a class=\"button button-ghost button-arrow\" href=\"https:\/\/hcp.biomarin.com\/en-us\/naglazyme\/mps-vi-management\/naglazyme-efficacy\/\" target=\"_self\">Learn more about NAGLAZYME efficacy<\/a><\/p>\n                            <\/div>\n\t\t\t\t\t                        <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-64187cde1ad4e\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>References:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>Akyol MU, Alden TD, Amartino H, <em>et al<\/em>. Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance. <em>Orphanet J Rare Dis<\/em>. 2019;14:118.\n<\/span><\/li>\n                                                                                                                                                <li><span>Giugliani R, Lampe C, Guffon N, <em>et al<\/em>. Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux\u2013Lamy syndrome)\u201410-year follow-up of patients who previously participated in an MPS VI Survey Study. <em>Am J Med Genet A<\/em>. 2014;164A(8):1953-1964. doi:10.1002\/ajmg.a.36584.\n<\/span><\/li>\n                                                                                                                                                <li><span>NAGLAZYME [package insert]. Novato, CA: BioMarin Pharmaceutical Inc; 2019.\n<\/span><\/li>\n                                                                                                                                                <li><span>Valayannopoulos V, Nicely H, Harmatz P, Turbeville S. Mucopolysaccharidosis VI. <em>Orphanet J Rare Dis<\/em>. 2010;5:5-20. doi:10.1186\/1750-1172-5-5.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-87","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MPS VI Management - BioMarin Naglazyme HCP EN-US<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/naglazyme\/mps-vi-management\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MPS VI Management - 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