{"id":8,"date":"2026-05-06T16:33:58","date_gmt":"2026-05-06T16:33:58","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/?page_id=8"},"modified":"2026-09-15T13:51:15","modified_gmt":"2026-09-15T13:51:15","slug":"home","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/","title":{"rendered":"Home"},"content":{"rendered":"
\n
<\/div>\n\t
<\/div>\n
\n\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t CLN2 disease is a rapidly progressing pediatric neurodegenerative disorder<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t

Stay a Step Ahead
\n\u2014Find CLN2 Early\n \n \n<\/h1>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n
\n
\n
\n <\/div>\n <\/div>\n<\/div>\n\n
\n\t
\n\t\t
\n\t\t\t
\n\t\t\t \t\t\t\t\t\t\t<\/div>\n\t\t\t
\n\t\t\t \n
\n
\n \"\"

The Natural Course of CLN2 Disease is Rapid\n<\/h4>\n \n

Children with CLN2 disease commonly experience a complete loss of cognitive abilities, motor function, and vision within the first decade of life.1,2<\/sup><\/p>\n \n <\/div>\n

\n \n

See Natural History Data <\/a><\/p>\n <\/div>\n<\/div>\n\n

\n
\n \"\"

Earlier Diagnosis is Critical with Testing\n<\/h4>\n \n

Given the rapid rate of progression, early diagnosis is essential to ensure that families can benefit from CLN2 management strategies and maximize quality time.3,4<\/sup><\/p>\n \n <\/div>\n

\n \n

Recognize Early Signs to Shorten Time to Diagnosis<\/a><\/p>\n <\/div>\n<\/div>\n\n

\n
\n \"\"

Optimize Care With CLN2 Disease Management Strategies\n<\/h4>\n \n

Experts have identified CLN2 disease management strategies that can greatly impact patient care and quality of life.4<\/sup><\/p>\n \n <\/div>\n

\n \n

View Recommendations<\/a><\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n

\n
\n\t\t
\n\t\t \t\t\t

References:\n<\/h4>\n\t\t\t\t\t\t
    \n
  1. Schulz A, Kohlsch\u00fctter A, Mink J, Simonati A, Williams R. NCL diseases \u2013 clinical perspectives. Biochimica et Biophysica Acta.<\/em> 2013;1832:1801-1806.\n<\/span><\/li>\n
  2. Malik K, Santucci K, Sremba L, et al. Neuronal Ceroid Lipofuscinoses Overview. 2001 Oct 10 [Updated 2025 May 29]. In: Adam MP, Bick S, Mirzaa GM, et al., editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026.\n<\/span><\/li>\n
  3. Nickel M, Simonati A, Jacoby D, et al. Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study. Lancet Child Adolesc Health.<\/em> 2018 Aug;2(8):582-590. doi: 10.1016\/S2352-4642(18)30179-2.\n<\/span><\/li>\n
  4. Williams RE, Adams HR, Blohm M, et al. Management Strategies for CLN2 Disease. Pediatr Neurol.<\/em> 2017 Apr;69:102-112. doi: 10.1016\/j.pediatrneurol.2017.01.034.\n<\/span><\/li>\n <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nCLN2 Connection | Home | HCP BioMarin<\/title>\n<meta name=\"description\" content=\"Learn about CLN2 disease, a rapidly progressing pediatric neurodegenerative disorder, and the importance of early diagnosis, testing and management.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hcp.biomarin.com\/en-us\/cln2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CLN2 Connection | Home | HCP BioMarin\" \/>\n<meta property=\"og:description\" content=\"Learn about CLN2 disease, a rapidly progressing pediatric neurodegenerative disorder, and the importance of early diagnosis, testing and management.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hcp.biomarin.com\/en-us\/cln2\/\" \/>\n<meta property=\"og:site_name\" content=\"BMRN CLN2 DSE HCP EN-US\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-15T13:51:15+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/\",\"url\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/\",\"name\":\"CLN2 Connection | Home | HCP BioMarin\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/#website\"},\"datePublished\":\"2026-05-06T16:33:58+00:00\",\"dateModified\":\"2026-09-15T13:51:15+00:00\",\"description\":\"Learn about CLN2 disease, a rapidly progressing pediatric neurodegenerative disorder, and the importance of early diagnosis, testing and management.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/#website\",\"url\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/\",\"name\":\"BMRN CLN2 DSE HCP EN-US\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/hcp.biomarin.com\\\/en-us\\\/cln2\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CLN2 Connection | Home | HCP BioMarin","description":"Learn about CLN2 disease, a rapidly progressing pediatric neurodegenerative disorder, and the importance of early diagnosis, testing and management.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/","og_locale":"en_US","og_type":"article","og_title":"CLN2 Connection | Home | HCP BioMarin","og_description":"Learn about CLN2 disease, a rapidly progressing pediatric neurodegenerative disorder, and the importance of early diagnosis, testing and management.","og_url":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/","og_site_name":"BMRN CLN2 DSE HCP EN-US","article_modified_time":"2026-09-15T13:51:15+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/","url":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/","name":"CLN2 Connection | Home | HCP BioMarin","isPartOf":{"@id":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/#website"},"datePublished":"2026-05-06T16:33:58+00:00","dateModified":"2026-09-15T13:51:15+00:00","description":"Learn about CLN2 disease, a rapidly progressing pediatric neurodegenerative disorder, and the importance of early diagnosis, testing and management.","breadcrumb":{"@id":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/hcp.biomarin.com\/en-us\/cln2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/"},{"@type":"ListItem","position":2,"name":"Home"}]},{"@type":"WebSite","@id":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/#website","url":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/","name":"BMRN CLN2 DSE HCP EN-US","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":37,"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":690,"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/pages\/8\/revisions\/690"}],"wp:attachment":[{"href":"https:\/\/hcp.biomarin.com\/en-us\/cln2\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}