{"id":2558,"date":"2025-08-05T13:48:21","date_gmt":"2025-08-05T13:48:21","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/?page_id=2558"},"modified":"2025-09-04T13:55:08","modified_gmt":"2025-09-04T13:55:08","slug":"understanding-achondroplasia","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/understanding-achondroplasia\/","title":{"rendered":"Understanding Achondroplasia"},"content":{"rendered":"<div id=\"acf-block-689083a01f723\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/understanding-achodroplasia-hero-desktop-v2.jpg?v=0.122);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/hero_old-1.png?v=0.122);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t    <img decoding=\"async\" class=\"branding\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/understanding-achondroplasia-hero-title.png?v=0.122\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t    <p>Inhibited bone growth can lead to multisystemic complications. See how you can impact your patients&#8217; care.<sup>1-3<\/sup><\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-6890844a8bf82\" class=\"block contact-representative block-zero-top\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cta-content\">\n\t\t\t                        <div class=\"content-block\">\n                                                    <h2 class=\"h3\">Connect with a BioMarin representative\n<\/h2>\n                                                                            <p>Learn about care and treatment for achondroplasia.<sup>4<\/sup><\/p>\n                                            <\/div>\n\t\t\t\t\t\t\t\t                    <div class=\"content-block\">\n                        <p><a class=\"button button-ghost button-arrow\" href=\"#acf-block-6891ca7ec7b7d\" target=\"_self\">Get connected<\/a><\/p>\n                    <\/div>\n                \t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6894843d5cfea\" class=\"block alt-split-block\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"left-column\">\n\t\t\t\t<div class=\"content-block first-block\">\n\t\t\t\t\t\t\t\t\t\t\t<h2>Bone growth is inhibited in achondroplasia<sup>1<\/sup><\/h2>\n<p>Achondroplasia is a rare genetic condition in which endochondral bone growth, the process of replacing cartilage with bone, is inhibited at the growth plates.<sup>1,3,5,6<\/sup><\/p>\n<p>1 in 25,000 people are born with achondroplasia.<sup>5<\/sup><\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"content-block second-block\">\n\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/understanding-achodroplasia-timeline.png?v=0.122\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t\t\t<div class=\"right-column\">\n\t\t\t\t<div class=\"content-block third-block\">\n\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" class=\"desktop\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/icon-skeleton.png?v=0.122\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" class=\"mobile\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/skeleton-mobile-copy-660x1024.png\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"content-block mobile-block\">\n\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/timeline-mobile.png?v=0.122\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-689088f800ad3\" class=\"block wrapped-content block-tight-bottom\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-689088f800b93\" class=\"block-wysiwyg\">\n            <h2 style=\"text-align: left\">Potential complications can impact quality of life and occur through adulthood<sup>2<\/sup><\/h2>\n<p style=\"text-align: left\">Inhibited bone growth can lead to progressive, multisystemic complications that can impact daily functioning and quality of life. These need to be proactively monitored from birth and throughout adulthood.<sup>1-3,26,27<\/sup><\/p>\n<p style=\"text-align: center\"><strong>You play an important role in initiating multidisciplinary care.<sup>3,27<\/sup><\/strong><\/p>\n<p>&nbsp;<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-689088f800c5c\" class=\"block split-content equal-bias\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                            \t\t                            \t\t                                                                    <ul class=\"icon-list\">\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/stenosis.svg);\">\n                                                    <p><strong>FORAMEN MAGNUM STENOSIS<br \/>\n<\/strong>May be associated with compression of the lower brain stem and higher mortality<sup>28-30<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/sleep.svg);\">\n                                                    <p><strong>OBSTRUCTIVE SLEEP APNEA<br \/>\n<\/strong>Affects &gt;50% of people with achondroplasia<sup>32<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/dental.svg);\">\n                                                    <p><strong>DENTAL ISSUES<br \/>\n<\/strong>Including misaligned teeth, a narrow palate, open bite, or underbite<sup>31,34<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/psychosocial.svg);\">\n                                                    <p><strong>PSYCHOSOCIAL IMPACT<br \/>\n<\/strong>Negative self-perception can lead to poor self-esteem<sup>37<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/pain.svg);\">\n                                                    <p><strong>CHRONIC PAIN<br \/>\n<\/strong>Especially back pain, which can result in reduced mobility<sup>34<\/sup><\/p>\n                                                <\/li>\n                                                                                    <\/ul>\n                                                                                                                        <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                            \t\t                            \t\t                                                                    <ul class=\"icon-list\">\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/otitus.svg);\">\n                                                    <p><strong>RECURRENT OTITIS MEDIA<br \/>\n<\/strong>Ear infections can affect up to 70% of people with achondroplasia, causing hearing issues or speech delays<sup>27,31<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/tibial.svg);\">\n                                                    <p><strong>GENU VARUM (TIBIAL BOWING)<br \/>\n<\/strong>Can affect walking and running<sup>33<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/functional.svg);\">\n                                                    <p><strong>FUNCTIONAL CHALLENGES<br \/>\n<\/strong>Can affect mobility, independence, and daily activities<sup>35,36<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/spine.svg);\">\n                                                    <p><strong>SPINAL STENOSIS<br \/>\n<\/strong>Can lead to leg weakness, incontinence, and chronic pain, especially in the back<sup>34,38<\/sup><\/p>\n                                                <\/li>\n                                                                                                                                                                                            <li style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/obesity.svg);\">\n                                                    <p><strong>OBESITY<br \/>\n<\/strong>Can lead to heart disease<sup>35,39<\/sup><\/p>\n                                                <\/li>\n                                                                                    <\/ul>\n                                                                                                                        <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6890897e62a9b\" class=\"block wrapped-content bg-band bg-band-alternative block-zero-top\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-689204b80b14f\" class=\"block-wysiwyg\">\n            <h2 style=\"text-align: center\">Your role in <span class=\"yellow-text\">multidisciplinary care<\/span><sup>3,27<\/sup><\/h2>\n<p style=\"text-align: center\">Proactive, early management is necessary for achondroplasia. Coordinated care is needed to provide optimal patient outcomes and to support their parents and caregivers.<sup>3,4,27,31,32,40<\/sup><\/p>\n    <\/div>\n\n<figure id=\"acf-block-6890897e62baa\">\n    <div class=\"image image-rounded image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2025\/08\/pediatrician-family-medicine-1900x1475.png\" alt=\"\" \/>            <\/div>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6890b2779c239\" class=\"block clinic-finder\" data-nonce=\"ed1d977c55\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"clinic-intro\">\n\t\t\t\t<h2>Find specialized care for your patients\n<\/h2>\n\t\t\t\t\t\t\t\t    <p>Help caregivers find a specialist in their area with our Achondroplasia Doctor Finder.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"tabbed-content\">\n\t\t\t\t<div class=\"tabbed-content\">\n\t\t\t\t\t<div class=\"box\">\n\t\t\t\t\t\t<div class=\"tab-content\">\n\t\t\t\t\t\t\t<div class=\"clinic-finder-form\">\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t\t    <p>Locate other healthcare providers who have experience caring for children with achondroplasia.<\/p>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"form-item\">\n\t\t\t\t\t\t\t\t\t<div class=\"linear-input\">\n\t\t\t\t\t\t\t\t\t\t<input id=\"clinic-finder-address\" type=\"text\" class=\"text google-places-autocomplete\" placeholder=\"Enter an address\">\n\t\t\t\t\t\t\t\t\t\t<select id=\"clinic-finder-radius\" class=\"text text-short\">\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"10\">Within 10 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"20\">Within 20 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"30\">Within 30 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"40\">Within 40 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"50\">Within 50 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"100\">Within 100 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"250\">Within 250 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"300\">Within 300 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t\t<option value=\"500\">Within 500 miles<\/option>\n\t\t\t\t\t\t\t\t\t\t<\/select>\n\t\t\t\t\t\t\t\t\t\t<input type=\"submit\" class=\"button\" value=\"Search\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t                                        <div class=\"footnote\">\n                                            <p>Search results are not comprehensive and do not reflect any endorsement or certifications from BioMarin.<\/p>\n<p>This directory is available for any healthcare provider who chooses to be listed and may not reflect all healthcare professionals in your area.<\/p>\n                                        <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"no-results\" style=\"display:none;\">\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t        <p>There are no clinics available within the distance you specified. You can expand your search area, or search for a different location instead.<\/p>\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"results\" style=\"display:none;\"><\/div>\n\n\t\t\t\t\t\t\t<div class=\"clinic-load-more\" style=\"display:none;\">\n\t\t\t\t\t\t\t    \t\t\t\t\t\t\t\t    <p><a class=\"button button-ghost\" href=\"#\">Load more<\/a><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n                            \t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"clinic-finder-terms-modal\" class=\"clinic-finder-terms white-popup-block mfp-hide\">\n\t<div class=\"box\">\n\t\t<p><a class=\"modal-close\" href=\"#\">Close terms<\/a><\/p>\n\t\t\t\t    <h1>Terms &amp; Conditions<\/h1>\n<ul>\n<li><strong>IMPORTANT:<\/strong> This [Disease] Doctor Finder provides information about healthcare professionals not affiliated with BioMarin Pharmaceutical Inc. (&#8220;BioMarin&#8221;).<\/li>\n<li>Healthcare professional enrollment and participation in the Achondroplasia Doctor Finder is voluntary and free of charge and is based solely on information provided by the listed healthcare professionals. The Achondroplasia Doctor Finder is open to all healthcare providers who opt in.<\/li>\n<li>BioMarin makes no express or implied warranties about the accuracy or completeness of information contained in this site\u2019s listings.<\/li>\n<li>Consult with your insurance provider and healthcare team and conduct your own research before selecting a healthcare provider.<\/li>\n<li>You are solely responsible for all communications or other interactions with any healthcare professional listed on the site.<\/li>\n<\/ul>\n<h2>By using this website, you agree that:<\/h2>\n<ul>\n<li>BioMarin makes no endorsement of, recommendations about, nor credentialing of any healthcare professional listed on the site, their insurance network status, or of the skills or services of any such healthcare professional.<\/li>\n<li>BioMarin is neither responsible nor liable for any care furnished by, or failure to provide care by, any healthcare professional identified using the [Disease] Doctor Finder.<\/li>\n<li>BioMarin is not responsible for verifying the accuracy of any licenses, skills, education, experience, or ability to practice of any healthcare professional listed on this site. You have the sole responsibility for choosing your healthcare provider and verifying that a particular healthcare professional has the appropriate qualifications and skills to provide medical care.<\/li>\n<li>BioMarin shall not, under any circumstance, be liable to you or any other person for any decision or action taken by you or any person arising from or related to information contained on this site<\/li>\n<\/ul>\n\t\t\n\t\t<div class=\"form-item check-item\">\n\t\t\t<input type=\"checkbox\" id=\"clinic-finder-accept-terms\">\n\t\t\t\t\t\t    <label for=\"clinic-finder-accept-terms\">By checking this box you have acknowledged that you have read and agree with the Terms and Conditions.<\/label>\n\t\t\t\t\t<\/div>\n\n\t\t<div class=\"form-item\">\n\t\t\t<input type=\"submit\" class=\"button\" value=\"Get Search Results\">\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6891ca7ec7b7d\" class=\"block split-column-contact-block\">\n    <div class=\"split-column-contact\">\n        <div class=\"wrapper\">\n            <div class=\"inner-wrapper\">\n                <div class=\"split-column-contact-content\">\n                    <div class=\"left-col\">\n                        <div class=\"text-box\">\n                            <h2>Request to speak with a BioMarin Representative<\/h2>\n                            <p>Take the next step and talk with a representative about care and treatment for your patients with achondroplasia.<sup>4<\/sup><\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"right-col\">\n                        <div class=\"column-header\">\n                            <div class=\"header\">\n                                <p>*Required fields<\/p>\n                            <\/div>\n                        <\/div>\n                        <form id=\"split-column-contact\" name=\"Request to speak with a BioMarin Representative\" class=\"form-box\">\n\n                            <div class=\"form-item\">\n                                <label for=\"first-name\">First name<span class=\"required\">*<\/span><\/label>\n                                <input class=\"text\" id=\"first-name\" type=\"text\" required\n                                data-pristine-required-message=\"Please enter your first name\">\n                            <\/div>\n\n                            <div class=\"form-item\">\n                                <label for=\"last-name\">Last name<span class=\"required\">*<\/span><\/label>\n                                <input class=\"text\" id=\"last-name\" type=\"text\" required\n                                data-pristine-required-message=\"Please enter your last name\">\n                            <\/div>\n\n                            <div class=\"form-item\">\n                                <label for=\"email\">Email address<span class=\"required\">*<\/span><\/label>\n                                <input class=\"text\" id=\"email\" type=\"email\" required\n                                data-pristine-required-message=\"Please enter your email address\">\n                            <\/div>\n\n                            <div class=\"form-item\">\n                                <label for=\"zip-code\">Postal code<span class=\"required\">*<\/span><\/label>\n                                <input class=\"text\" id=\"zip-code\" type=\"text\" required\n                                data-pristine-required-message=\"Please enter your ZIP code\"\n                                data-pristine-pattern-message=\"Please enter a valid ZIP code\"\n                                data-pristine-pattern=\"\/^\\d{5}(-\\d{4})?$\/i\">\n                            <\/div>\n\n                            <div class=\"form-item\">\n                                <label for=\"contact-type\">Medical specialty<span class=\"required\">*<\/span><\/label>\n                                <select class=\"text\" id=\"contact-type\" required\n                                data-pristine-required-message=\"Please select an option\">\n                                    <option value=\"\">Select your specialty<\/option>\n                                    <option>Audiology<\/option>\n                                    <option>Behavioral Neurology &#038; Neuropsychiatry<\/option>\n                                    <option>Cardiology<\/option>\n                                    <option>Clinical Biochemical Genetics<\/option>\n                                    <option>Diagnostic Radiology<\/option>\n                                    <option>Electroencephalography<\/option>\n                                    <option>Endocrinology, Diabetes &#038; Metabolism<\/option>\n                                    <option>ENT\/Otorhinolaryngologist<\/option>\n                                    <option>Gastroenterology<\/option>\n                                    <option>General Practice\/Family<\/option>\n                                    <option>Genetics<\/option>\n                                    <option>Hearing and Speech<\/option>\n                                    <option>Internal Medicine<\/option>\n                                    <option>Neonatology<\/option>\n                                    <option>Neurology<\/option>\n                                    <option>Nutrition, Metabolic<\/option>\n                                    <option>Obstetrics<\/option>\n                                    <option>Orthopedics<\/option>\n                                    <option>Pediatric Endocrinology<\/option>\n                                    <option>Pediatric Endocrinology, Diabetes &#038; Metabolism<\/option>\n                                    <option>Pediatric ENT<\/option>\n                                    <option>Pediatric Gastroenterology<\/option>\n                                    <option>Pediatric Gastroenterology &#038; Metabolism<\/option>\n                                    <option>Pediatric Genetics<\/option>\n                                    <option>Pediatric Metabolism<\/option>\n                                    <option>Pediatric Neurology<\/option>\n                                    <option>Pediatric Neurosurgery<\/option>\n                                    <option>Pediatric Orthopedics<\/option>\n                                    <option>Pediatric Radiology<\/option>\n                                    <option>Pediatrics<\/option>\n                                    <option>Primary Care<\/option>\n                                    <option>Psychology \/ Psychiatry<\/option>\n                                    <option>Pulmonology<\/option>\n                                    <option>Radiology (MRI imaging)<\/option>\n                                    <option>Research<\/option>\n                                    <option>Social Worker<\/option>\n                                    <option>Surgery<\/option>\n                                <\/select>\n                            <\/div>\n\n                            <div class=\"form-item\">\n                                <label for=\"phone-number\">Phone number<\/label>\n                                <input class=\"text\" id=\"phone-number\" type=\"text\"\n                                data-pristine-required-message=\"Please enter your phone number\"\n                                data-pristine-pattern-message=\"Please enter a valid phone number\"\n                                data-pristine-pattern=\"\/^\\(?([0-9]{3})\\)?[-. ]?([0-9]{3})[-. ]?([0-9]{4})$\/\">\n                            <\/div>\n\n                            <div class=\"form-item check-item\">\n                                <input type=\"checkbox\" id=\"accept-ts-cs\" name=\"accept_ts_cs\" required\n                                data-pristine-required-message=\"Please agree to the terms of use\">\n                                <label for=\"accept-ts-cs\" class=\"small-text\">By checking this box and clicking &#8220;START THE CONVERSATION&#8221; below, I confirm I am at least 18 years old; confirm I agree to BioMarin&#8217;s <a href=\"https:\/\/www.biomarin.com\/biomarin-data-privacy-center\/\" target=\"_blank\">Privacy Policy and CCPA Notice<\/a> and <a href=\"https:\/\/www.biomarin.com\/terms-of-use\/en-us\/\" target=\"_blank\">Terms of Use<\/a>; consent to BioMarin, its successors, agents, and\/or assignees using the email address and\/or phone number I have provided to contact me to provide more information about achondroplasia and keep me informed about news and developments, market research or surveys, or other opportunities that may be of interest to me; and confirm I understand these communications\/materials may contain information that markets or advertises BioMarin products, goods, or services.<span class=\"required\">*<\/span><\/label>\n                            <\/div>\n\n                            <div class=\"form-item\">\n                                <input type=\"submit\" class=\"button button-arrow\" value=\"START THE CONVERSATION\">\n                            <\/div>\n                        <\/form>\n                        <form id=\"mktoForm_3470\" style=\"display:none;\"><\/form>\n\n                        <div class=\"form-success-confirmation\" style=\"display:none;\">\n                            <h2>Thank you!<\/h2>\n                            <p>We&#8217;ll be in touch soon with additional information.<\/p>\n<p>Please find more resources about achondroplasia, the importance of multidisciplinary care, and how you can further support your patients.<\/p>\n                                                            <p class=\"inline-buttons\">\n                                    <a class=\"button button-arrow\" href=\"#\" target=\"_self\">Continue Learning<\/a>                                <\/p>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-68908c844129f\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-68908c84412d7\" class=\"block-wysiwyg\">\n            <h4>References:<\/h4>\n<ol>\n<li>Horton WA, Hall JG, Hecht JT. Achondroplasia. <em>Lancet<\/em>. 2007;370(9582):162-172.<\/li>\n<li>Hoover-Fong J, Cheung MS, Fano V, et al. Lifetime impact of achondroplasia: current evidence and perspectives on the natural history. <em>Bone<\/em>. 2021;146:115872.<\/li>\n<li>Savarirayan R, Ireland P, Irving M, et al. International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia. <em>Nat Rev Endocrinol<\/em>. 2022;18(3):173-189.<\/li>\n<li>Savarirayan R, Hoover-Fong J, Ozono K, et al. International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia. <em>Nat Rev Endocrinol<\/em>. 2025;21(5):314-324.<\/li>\n<li>Foreman PK, van Kessel F, van Hoorn R, et al. Birth prevalence of achondroplasia: a systematic literature review and meta-analysis. <em>Am J Med Genet A<\/em>. 2020;182(10):2297-2316.<\/li>\n<li>Mackie EJ, Tatarczuch L, Mirams M. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. <em>J Endocrinol<\/em>. 2011;211(2):109-121.<\/li>\n<li>Clarke B. Normal bone anatomy and physiology. <em>Clin J Am Soc Nephrol<\/em>. 2008;3(suppl 3):S131-S139.<\/li>\n<li>Breeland G, Sinkler MA, Menezes RG. Embryology, bone ossification. In: StatPearls. StatPearls Publishing; 2023. Accessed April 23, 2025. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539718\/<\/li>\n<li>Berendsen AD, Olsen BR. Bone development. <em>Bone<\/em>. 2015;80:14-18.<\/li>\n<li>\u00a0Cowan PT, Launico MV, Kahai P. Anatomy, bones. In: StatPearls. StatPearls Publishing; 2024. Accessed April 23, 2025. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537199\/<\/li>\n<li>\u00a0Johns Hopkins Medicine. Anatomy of the bone. Accessed April 23, 2025. https:\/\/www.hopkinsmedicine.org\/health\/wellness-and-prevention\/anatomy-of-the-bone<\/li>\n<li>Jin SW, Sim KB, Kim SD. Development and growth of the normal cranial vault: an embryologic review. <em>J Korean Neurosurg Soc. <\/em>2016;59(3):192-196.<\/li>\n<li>Anderson BW, Kortz MW, Black AC, et al. Anatomy, head and neck, skull. In: StatPearls. StatPearls Publishing; 2023. Accessed April 23, 2025. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499834\/<\/li>\n<li>Encyclopaedia Britannica. Science &amp; Tech. Skull. Accessed April 23, 2025. https:\/\/www.britannica.com\/science\/skull<\/li>\n<li>Hall R, Beals K, Neumann H, et al. <em>Introduction to Human Osteology<\/em>. Grand Valley State University; 2008.<\/li>\n<li>Encyclopaedia Britannica. Science &amp; Tech. Clavicle. Accessed April 23, 2025. https:\/\/www.britannica.com\/science\/clavicle<\/li>\n<li>Baron J, S\u00e4vendahl L, De Luca F, et al. Short and tall stature: a new paradigm emerges. <em>Nat Rev Endocrinol<\/em>. 2015;11(12):735-746.<\/li>\n<li>Shahzad F. Pediatric mandible reconstruction: controversies and considerations. <em>Plast Reconstr Surg Glob Open<\/em>. 2020;8(12):e3285.<\/li>\n<li>Bartleby. Henry Gray (1825-1861). Anatomy of the Human Body. 1918. Fig. 237. Accessed May 7, 2025. https:\/\/www.bartleby.com\/lit-hub\/anatomy-of-the-human-body\/fig-237\/<\/li>\n<li>Encyclopaedia Britannica. Science &amp; Tech. Pelvis. Accessed May 7, 2025. https:\/\/www.britannica.com\/science\/pelvis<\/li>\n<li>Mayo Clinic. Growth plate fracture. Accessed May 7, 2025. https:\/\/www.mayoclinic.org\/diseases-conditions\/growth-plate-fractures\/multimedia\/growth-plate-fracture\/img-20005879<\/li>\n<li>International Center for Limb Lengthening. Growth arrest. Accessed June 10, 2025. https:\/\/www.limblength.org\/conditions\/growth-arrest\/<\/li>\n<li>Hsieh YL, Wei X, Wang Y, et al. Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses. <em>Bone<\/em>. 2021;153:116142.<\/li>\n<li>Musculoskeletal Key. Cranial and pelvic \u201cvertebrae\u201d are they real vertebrae? Accessed June 10, 2025. https:\/\/musculoskeletalkey.com\/cranial-and-pelvic-vertebrae-are-they-real-vertebrae\/<\/li>\n<li>Young M, Selleri L, Capellini TD. Genetics of scapula and pelvis development: An evolutionary perspective. <em>Curr Top Dev Biol<\/em>. 2019;132:311-349.<\/li>\n<li>Constantinides C, Landis SH, Jarrett J, et al. Quality of life, physical functioning, and psychosocial function among patients with achondroplasia: a targeted literature review. <em>Disabil Rehabil<\/em>. 2022;44(21):6166-6178.<\/li>\n<li>Hoover-Fong J, Scott CI, Jones MC; AAP Committee on Genetics. Health supervision for people with achondroplasia. <em>Pediatrics<\/em>. 2020;145(6):e20201010.<\/li>\n<li>Hecht JT, Francomano CA, Horton WA, et al. Mortality in achondroplasia. <em>Am J Hum Genet<\/em>. 1987;41(3):454-464.<\/li>\n<li>Hecht JT, Horton WA, Reid CS, et al. Growth of the foramen magnum in achondroplasia. <em>Am J Med Genet<\/em>. 1989;32(4):528-535.<\/li>\n<li>Hecht JT, Bodensteiner JB, Butler IJ. Neurologic manifestations of achondroplasia. <em>Handb Clin Neurol<\/em>. 2014;119:551-563.<\/li>\n<li>Pauli RM. Achondroplasia: a comprehensive clinical review. <em>Orphanet J Rare Dis<\/em>. 2019;14(1):1.<\/li>\n<li>Unger S, Bonaf\u00e9 L, Gouze E. Current care and investigational therapies in achondroplasia. <em>Curr Osteoporos Rep<\/em>. 2017;15(2):53-60.<\/li>\n<li>Shirley ED, Ain MC. Achondroplasia: manifestations and treatment. <em>J Am Acad Orthop Surg<\/em>. 2009;17(4):231-241.<\/li>\n<li>Hunter AG, Bankier A, Rogers JG, et al. Medical complications of achondroplasia: a multicentre patient review. <em>J Med Genet<\/em>. 1998;35(9):705-712.<\/li>\n<li>Fredwall SO, Maanum G, Johansen H, et al. Current knowledge of medical complications in adults with achondroplasia: A scoping review. <em>Clin Genet<\/em>. 2020;97(1):179-197.<\/li>\n<li>Alade Y, Tunkel D, Schulze K, et al. Cross-sectional assessment of pain and physical function in skeletal dysplasia patients. <em>Clin Genet<\/em>. 2013;84(3):237-243.<\/li>\n<li>Nishimura N, Hanaki K. Psychosocial profiles of children with achondroplasia in terms of their short stature-related stress: a nationwide survey in Japan. <em>J Clin Nurs<\/em>. 2014;23(21-22):3045-3056.<\/li>\n<li>Ain MC, Abdullah MA, Ting BL, et al. Progression of low back and lower extremity pain in a cohort of patients with achondroplasia. <em>J Neurosurg Spine<\/em>. 2010;13(3):335-340.<\/li>\n<li>Hecht JT, Hood OJ, Schwartz RJ, et al. Obesity in achondroplasia. <em>Am J Med Genet<\/em>. 1988;31(3):597-602.<\/li>\n<li>Wright MJ, Irving MD. Clinical management of achondroplasia. <em>Arch Dis Child<\/em>. 2012;97(2):129-134.<\/li>\n<\/ol>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-campaign.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-2558","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Understanding Achondroplasia | Healthcare Professionals<\/title>\n<meta name=\"description\" content=\"Proactive, early management is necessary for achondroplasia. 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