{"id":23,"date":"2022-11-03T18:35:22","date_gmt":"2022-11-03T18:35:22","guid":{"rendered":"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/?page_id=23"},"modified":"2025-05-14T12:44:12","modified_gmt":"2025-05-14T12:44:12","slug":"research","status":"publish","type":"page","link":"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div id=\"acf-block-6425687893c36\" class=\"hero hero-no-overlay\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2022\/11\/management_hero.jpg?v=0.122);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2022\/11\/management_hero.jpg?v=0.122);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>Ongoing Research into Achondroplasia\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-6425687893c59\" class=\"block wrapped-content\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-6425687893c76\" class=\"block-wysiwyg\">\n            <h2>Ongoing research into impaired endochondral bone growth<sup>4<\/sup><\/h2>\n<p>Current treatment does not address the underlying cause of achondroplasia and is limited to management of complications. However, many different approaches to addressing excessive FGFR3 activity have been proposed and are under clinical trial investigation.<sup>1-3<\/sup><\/p>\n<p><strong>None of these approaches has been determined to be safe or effective or approved for use.<\/strong><\/p>\n    <\/div>\n\n<figure id=\"acf-block-6425687893c91\">\n    <div class=\"image image-rounded image-align-left\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/hcp.biomarin.com\/en-us\/achondroplasia\/wp-content\/uploads\/sites\/2\/2022\/11\/research-1000.jpg?v=0.122\" alt=\"\" \/>            <\/div>\n    <\/figure>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-6425687893cb8\" class=\"block references\">\n    <div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t    \t\t\t    <h4>References:\n<\/h4>\n\t\t\t\t\t\t                <ol>\n                                                                                                                        <li><span>H\u00f6gler W, Ward LM. New developments in the management of achondroplasia. <em>Wien Med Wochenschr<\/em>. 2020;170(5-6):104-111.\n<\/span><\/li>\n                                                                                                                                                <li><span>Ireland PJ, Pacey V, Zankl A, Edwards P, Johnston LM, Savarirayan R. Optimal management of complications associated with achondroplasia. <em>Appl Clin Genet.<\/em> 2014;7:117-125. Published online June 24, 2014.\n<\/span><\/li>\n                                                                                                                                                <li><span>Wright MJ, Irving MD. Clinical management of achondroplasia. <em>Arch Dis Child<\/em>. 2012;97(2):129-134.\n<\/span><\/li>\n                                                                                                                                                <li><span>Laederich MB, Horton WA. Achondroplasia: pathogenesis and implications for future treatment.<em> Curr Opin Pediatr<\/em>. 2010;22(4):516-523.\n<\/span><\/li>\n                                                            <\/ol>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-6425687893f3b\" class=\"block print-page\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <p><a class=\"button button-print\" href=\"#\">Print this page<\/a><\/p>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Achondroplasia 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